{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:11:45Z","timestamp":1791861105941,"version":"4.3.4"},"reference-count":200,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31472238"],"award-info":[{"award-number":["31472238"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["242300420146"],"award-info":[{"award-number":["242300420146"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Luoyang Rural Revitalization Public Welfare Special Project","award":["2302030A"],"award-info":[{"award-number":["2302030A"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Eimeria<\/jats:italic>\n                    is an intracellular obligate apicomplexan parasite that parasitizes the intestinal epithelial cells of livestock and poultry, exhibiting strong host and tissue tropism. Parasite\u2013host interactions involve complex networks and vary as the parasites develop in the host. However, understanding the underlying mechanisms remains a challenge. Acknowledging the lack of studies on\n                    <jats:italic>Eimeria<\/jats:italic>\n                    invasion mechanism, we described the possible invasion process through comparative analysis with other apicomplexan parasites and explored the fact that parasite\u2013host interactions serve as a prerequisite for successful recognition, penetration of the intestinal mechanical barrier, and completion of the invasion. Although it is recognized that microbiota can enhance the host immune capacity to resist\n                    <jats:italic>Eimeria<\/jats:italic>\n                    invasion, changes in the microenvironment can, in turn, contribute to\n                    <jats:italic>Eimeria<\/jats:italic>\n                    invasion and may be associated with reduced immune capacity. We also discuss the immune evasion strategies of\n                    <jats:italic>Eimeria<\/jats:italic>\n                    , emphasizing that the host employs sophisticated immune regulatory mechanisms to suppress immune evasion by parasites, thereby sustaining a balanced immune response. This review aims to deepen our understanding of\n                    <jats:italic>Eimeria<\/jats:italic>\n                    \u2013host interactions, providing a theoretical basis for the study of the pathogenicity of\n                    <jats:italic>Eimeria<\/jats:italic>\n                    and the development of novel anticoccidial drugs.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012689","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T13:21:51Z","timestamp":1732281711000},"page":"e1012689","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Eimeria: Navigating complex intestinal ecosystems"],"prefix":"10.1371","volume":"20","author":[{"given":"Shengjie","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erjie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-3898","authenticated-orcid":true,"given":"Bianhua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"issue":"1","key":"ppat.1012689.ref001","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13567-020-00837-2","article-title":"Re-calculating 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of Eimeria tenella: Characterization and Application of Quantitative Methods to Assess Sporozoite Invasion and Endogenous Development in Cell Culture.","author":"V Marugan-Hernandez","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"ppat.1012689.ref012","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13071-018-2622-1","article-title":"Establishment of an in vitro chicken epithelial cell line model to investigate Eimeria tenella gamete development","volume":"11","author":"FI Bussi\u00e8re","year":"2018","journal-title":"Parasit Vectors"},{"issue":"6","key":"ppat.1012689.ref013","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1462-5822.2011.01597.x","article-title":"The moving junction of apicomplexan parasites: a key structure for invasion","volume":"13","author":"S Besteiro","year":"2011","journal-title":"Cell 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the domestic fowl (Gallus domesticus): A lectin histochemistry study.","volume":"21","author":"J Alroy","year":"1989","journal-title":"Histochem J"},{"issue":"1","key":"ppat.1012689.ref035","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13567-020-00809-6","article-title":"EtMIC3 and its receptors BAG1 and ENDOUL are essential for site-specific invasion of Eimeria tenella in chickens","volume":"51","author":"WY Li","year":"2020","journal-title":"Vet Res"},{"key":"ppat.1012689.ref036","doi-asserted-by":"crossref","first-page":"106549","DOI":"10.1016\/j.micpath.2024.106549","article-title":"Host protein EPCAM interacting with EtMIC8-EGF is essential for attachment and invasion of Eimeria tenella in chickens","volume":"188","author":"LY Sun","year":"2024","journal-title":"Microb Pathog"},{"issue":"11","key":"ppat.1012689.ref037","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1007\/s00436-014-4087-2","article-title":"Preparation and initial application of monoclonal antibodies that recognize Eimeria tenella microneme proteins 1 and 2","volume":"113","author":"Q Liu","year":"2014","journal-title":"Parasitol Res"},{"issue":"6","key":"ppat.1012689.ref038","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s00436-013-3389-0","article-title":"Partial protective of chickens against Eimeria tenella challenge with recombinant EtMIC-1 antigen","volume":"112","author":"NS Qi","year":"2013","journal-title":"Parasitol Res"},{"issue":"11","key":"ppat.1012689.ref039","first-page":"e00596","article-title":"Identification and Application of Epitopes in EtMIC1 of Eimeria tenella Recognized by the Monoclonal Antibodies 1-A1 and 1-H2","volume":"87","author":"NN Zhao","year":"2019","journal-title":"Infect Immun"},{"issue":"28","key":"ppat.1012689.ref040","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1016\/j.vaccine.2005.01.144","article-title":"In ovo vaccination with the Eimeria tenella EtMIC2 gene induces protective immunity 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