{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:50:24Z","timestamp":1792018224496,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012700","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2604203"],"award-info":[{"award-number":["2022YFC2604203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Project of Sanya Yazhou Bay Science and Technology City","award":["SCKJ-JYRC-2022-08"],"award-info":[{"award-number":["SCKJ-JYRC-2022-08"]}]},{"DOI":"10.13039\/501100002301","name":"Estonian Research Council","doi-asserted-by":"crossref","award":["PRG1154"],"award-info":[{"award-number":["PRG1154"]}],"id":[{"id":"10.13039\/501100002301","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Alphaviruses are important arthropod-transmitted pathogens of humans and livestock. Getah virus (GETV) is an arthritogenic alphavirus that causes disease in horses and piglets; it also poses a potential threat to humans. A live attenuated vaccine candidate named GETV-3\u0394S2-CM1, harbouring a deletion in nonstructural protein 3 and substitutions in the capsid protein, is genetically stable and exhibits robust immunogenicity. It was shown to confer passive protection to piglets born to immunized sows. In mice, a single dose of GETV-3\u0394S2-CM1 protected against infection with different strains of GETV, Semliki Forest virus, Ross River virus, o\u2019nyong\u2019nyong virus, chikungunya virus, and Barmah Forest virus. Chimaeras based on the GETV-3\u0394S2-CM1 backbone maintained both the attenuated phenotype and high immunogenicity. The safety, efficacy, and ability to induce protection against multiple alphaviruses highlights the potential of GETV-3\u0394S2-CM1 and chimaeras using this backbone as promising vaccine candidates. By contributing simultaneously to the wellbeing of animals and humans, our universal next generation vaccine strategy helps to achieve \"One Health\" goals.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012700","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T18:42:53Z","timestamp":1731955373000},"page":"e1012700","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Attenuated Getah virus confers protection against multiple arthritogenic alphaviruses"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1729-4776","authenticated-orcid":true,"given":"Zhiwen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Merits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margus","family":"Varjak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjie","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-1185","authenticated-orcid":true,"given":"Shuo","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"issue":"5","key":"ppat.1012700.ref001","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3390\/v14050969","article-title":"A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development","volume":"14","author":"TYV de Lima Cavalcanti","year":"2022","journal-title":"Viruses"},{"issue":"1","key":"ppat.1012700.ref002","doi-asserted-by":"crossref","first-page":"e00104-16","DOI":"10.1128\/CMR.00104-16","article-title":"Vaccine and Therapeutic Options To Control Chikungunya Virus","volume":"31","author":"AM Powers","year":"2018","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"ppat.1012700.ref003","doi-asserted-by":"crossref","first-page":"e83527","DOI":"10.1172\/jci.insight.83527","article-title":"Attenuated and vectored vaccines protect nonhuman primates against Chikungunya virus","volume":"2","author":"P Roques","year":"2017","journal-title":"JCI Insight"},{"issue":"10394","key":"ppat.1012700.ref004","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0140-6736(23)00641-4","article-title":"Safety and immunogenicity of a single-shot live-attenuated chikungunya vaccine: a double-blind, multicentre, randomised, placebo-controlled, phase 3 trial","volume":"401","author":"M Schneider","year":"2023","journal-title":"Lancet"},{"issue":"7\u20138","key":"ppat.1012700.ref005","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/S0264-410X(98)00315-6","article-title":"TC-83 vaccine protects against airborne or subcutaneous challenge with heterologous mouse-virulent strains of Venezuelan equine encephalitis virus","volume":"17","author":"RJ Phillpotts","year":"1999","journal-title":"Vaccine"},{"issue":"16","key":"ppat.1012700.ref006","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1016\/j.vaccine.2011.01.076","article-title":"Probing the attenuation and protective efficacy of a candidate chikungunya virus vaccine in mice with compromised interferon (IFN) signaling","volume":"29","author":"CD Partidos","year":"2011","journal-title":"Vaccine"},{"issue":"8","key":"ppat.1012700.ref007","doi-asserted-by":"crossref","first-page":"945","DOI":"10.3390\/pathogens11080945","article-title":"Getah Virus (Alphavirus): An Emerging, Spreading Zoonotic Virus","volume":"11","author":"B Li","year":"2022","journal-title":"Pathogens"},{"issue":"1","key":"ppat.1012700.ref008","doi-asserted-by":"crossref","first-page":"e0109122","DOI":"10.1128\/jvi.01091-22","article-title":"Early Genomic Surveillance and Phylogeographic Analysis of Getah Virus, a Reemerging Arbovirus, in Livestock in China","volume":"97","author":"J Zhao","year":"2023","journal-title":"J Virol"},{"issue":"8032","key":"ppat.1012700.ref009","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s41586-024-07901-3","article-title":"Farmed fur animals harbour viruses with zoonotic spillover potential","volume":"634","author":"J Zhao","year":"2024","journal-title":"Nature"},{"issue":"3","key":"ppat.1012700.ref010","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/tbed.12867","article-title":"An outbreak of Getah virus infection among pigs in China, 2017","volume":"65","author":"T Yang","year":"2018","journal-title":"Transbound Emerg Dis"},{"issue":"4","key":"ppat.1012700.ref011","first-page":"730","article-title":"Isolation of Getah virus from mosquitos collected on Hainan Island, China, and results of a serosurvey","volume":"23","author":"XD Li","year":"1992","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"1","key":"ppat.1012700.ref012","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0035-9203(75)90008-5","article-title":"Arbovirus infections in Sarawak, October 1968-February 1970: GETAH virus isolations from mosquitoes","volume":"69","author":"DI Simpson","year":"1975","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"6","key":"ppat.1012700.ref013","doi-asserted-by":"crossref","first-page":"e0175121","DOI":"10.1128\/jvi.01751-21","article-title":"Attenuation of Getah Virus by a Single Amino Acid Substitution at Residue 253 of the E2 Protein that Might Be Part of a New Heparan Sulfate Binding Site on Alphaviruses","volume":"96","author":"N Wang","year":"2022","journal-title":"J Virol"},{"issue":"5","key":"ppat.1012700.ref014","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3201\/eid2105.141975","article-title":"Getah Virus Infection among Racehorses, Japan, 2014","volume":"21","author":"M Nemoto","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"ppat.1012700.ref015","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3390\/vaccines8020209","article-title":"Arthritogenic Alphavirus Vaccines: Serogrouping Versus Cross-Protection in Mouse Models","volume":"8","author":"W Nguyen","year":"2020","journal-title":"Vaccines (Basel)"},{"issue":"5","key":"ppat.1012700.ref016","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1128\/JVI.03453-13","article-title":"Novel attenuated Chikungunya vaccine candidates elicit protective immunity in C57BL\/6 mice","volume":"88","author":"D Halleng\u00e4rd","year":"2014","journal-title":"J Virol"},{"issue":"1","key":"ppat.1012700.ref017","doi-asserted-by":"crossref","first-page":"e01970","DOI":"10.1128\/mBio.01970-16","article-title":"Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design","volume":"8","author":"A Taylor","year":"2017","journal-title":"mBio"},{"issue":"5","key":"ppat.1012700.ref018","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/v10050226","article-title":"Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus","volume":"10","author":"M Mutso","year":"2018","journal-title":"Viruses"},{"issue":"16","key":"ppat.1012700.ref019","doi-asserted-by":"crossref","first-page":"e00838","DOI":"10.1128\/JVI.00838-18","article-title":"Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode","volume":"92","author":"CD Meshram","year":"2018","journal-title":"J Virol"},{"key":"ppat.1012700.ref020","doi-asserted-by":"crossref","first-page":"106851","DOI":"10.1016\/j.domaniend.2024.106851","article-title":"The role of hormones in the regulation of lactogenic immunity in porcine and bovine species","volume":"88","author":"K Hua","year":"2024","journal-title":"Domest Anim Endocrinol"},{"issue":"2","key":"ppat.1012700.ref021","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nm.4253","article-title":"A chikungunya fever vaccine utilizing an insect-specific virus platform","volume":"23","author":"JH Erasmus","year":"2017","journal-title":"Nat Med"},{"issue":"17","key":"ppat.1012700.ref022","doi-asserted-by":"crossref","first-page":"9278","DOI":"10.1128\/JVI.77.17.9278-9286.2003","article-title":"Recombinant sindbis\/Venezuelan equine encephalitis virus is highly attenuated and immunogenic","volume":"77","author":"S Paessler","year":"2003","journal-title":"J Virol"},{"issue":"9","key":"ppat.1012700.ref023","doi-asserted-by":"crossref","first-page":"e1008825","DOI":"10.1371\/journal.ppat.1008825","article-title":"Cross-utilisation of template RNAs by alphavirus replicases","volume":"16","author":"LS Lello","year":"2020","journal-title":"PLoS Pathog"},{"issue":"20","key":"ppat.1012700.ref024","doi-asserted-by":"crossref","first-page":"e0035521","DOI":"10.1128\/JVI.00355-21","article-title":"nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity","volume":"95","author":"LS Lello","year":"2021","journal-title":"J Virol"},{"issue":"1","key":"ppat.1012700.ref025","doi-asserted-by":"crossref","first-page":"e0136822","DOI":"10.1128\/jvi.01368-22","article-title":"Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus","volume":"97","author":"LS Lello","year":"2023","journal-title":"J Virol"},{"issue":"16","key":"ppat.1012700.ref026","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1128\/JVI.00644-11","article-title":"Conservation of a packaging signal and the viral genome RNA packaging mechanism in alphavirus evolution","volume":"85","author":"DY Kim","year":"2011","journal-title":"J Virol"},{"issue":"21","key":"ppat.1012700.ref027","doi-asserted-by":"crossref","first-page":"11030","DOI":"10.1128\/JVI.01186-15","article-title":"Differences in Processing Determinants of Nonstructural Polyprotein and in the Sequence of Nonstructural Protein 3 Affect Neurovirulence of Semliki Forest Virus","volume":"89","author":"S Saul","year":"2015","journal-title":"J Virol"},{"issue":"6","key":"ppat.1012700.ref028","doi-asserted-by":"crossref","first-page":"e1007842","DOI":"10.1371\/journal.ppat.1007842","article-title":"Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery","volume":"15","author":"B G\u00f6tte","year":"2019","journal-title":"PLoS Pathog"},{"issue":"8","key":"ppat.1012700.ref029","doi-asserted-by":"crossref","first-page":"e1005810","DOI":"10.1371\/journal.ppat.1005810","article-title":"New World and Old World Alphaviruses Have Evolved to Exploit Different Components of Stress Granules, FXR and G3BP Proteins, for Assembly of Viral Replication Complexes","volume":"12","author":"DY Kim","year":"2016","journal-title":"PLoS Pathog"},{"issue":"1","key":"ppat.1012700.ref030","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1038\/s41467-023-42330-2","article-title":"FHL1 promotes chikungunya and o\u2019nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design","volume":"14","author":"WH Ng","year":"2023","journal-title":"Nat Commun"},{"issue":"7777","key":"ppat.1012700.ref031","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-019-1578-4","article-title":"FHL1 is a major host factor for chikungunya virus infection","volume":"574","author":"L Meertens","year":"2019","journal-title":"Nature"},{"issue":"11","key":"ppat.1012700.ref032","doi-asserted-by":"crossref","first-page":"e1002383","DOI":"10.1371\/journal.ppat.1002383","article-title":"SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication","volume":"7","author":"M Neuvonen","year":"2011","journal-title":"PLoS Pathog"},{"issue":"14","key":"ppat.1012700.ref033","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1128\/JVI.01283-07","article-title":"A five-amino-acid deletion of the eastern equine encephalitis virus capsid protein attenuates replication in mammalian systems but not in mosquito cells","volume":"82","author":"PV Aguilar","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"ppat.1012700.ref034","doi-asserted-by":"crossref","first-page":"2300452","DOI":"10.1080\/22221751.2023.2300452","article-title":"Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice","volume":"13","author":"VD Landers","year":"2024","journal-title":"Emerg Microbes Infect"},{"issue":"17","key":"ppat.1012700.ref035","doi-asserted-by":"crossref","first-page":"e00617-20","DOI":"10.1128\/JVI.00617-20","article-title":"Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence","volume":"94","author":"CD Meshram","year":"2020","journal-title":"J Virol"},{"issue":"5","key":"ppat.1012700.ref036","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cell.2015.10.050","article-title":"Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress","volume":"163","author":"JM Fox","year":"2015","journal-title":"Cell"},{"issue":"12","key":"ppat.1012700.ref037","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1016\/j.cell.2023.05.019","article-title":"Vaccine elicitation and structural basis for antibody protection against alphaviruses","volume":"186","author":"MS Sutton","year":"2023","journal-title":"Cell"},{"issue":"1","key":"ppat.1012700.ref038","doi-asserted-by":"crossref","first-page":"108962","DOI":"10.1016\/j.celrep.2021.108962","article-title":"The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies","volume":"35","author":"JT Earnest","year":"2021","journal-title":"Cell Rep"},{"key":"ppat.1012700.ref039","doi-asserted-by":"crossref","first-page":"849662","DOI":"10.3389\/fcimb.2022.849662","article-title":"Metagenomic Analysis of Togaviridae in Mosquito Viromes Isolated From Yunnan Province in China Reveals Genes from Chikungunya and Ross River Viruses","volume":"12","author":"G Feng","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"ppat.1012700.ref040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41577-024-01016-6","article-title":"Generating prophylactic immunity against arboviruses in vertebrates and invertebrates","volume":"24","author":"DJ Rawle","year":"2024","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"ppat.1012700.ref041","doi-asserted-by":"crossref","first-page":"e2250133","DOI":"10.1002\/eji.202250133","article-title":"YF17D-based vaccines\u2014standing on the shoulders of a giant","volume":"54","author":"L Sanchez-Felipe","year":"2024","journal-title":"Eur J Immunol"},{"issue":"15","key":"ppat.1012700.ref042","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.1128\/JVI.03645-14","article-title":"Ability of the Encephalitic Arbovirus Semliki Forest Virus To Cross the Blood-Brain Barrier Is Determined by the Charge of the E2 Glycoprotein","volume":"89","author":"MC Ferguson","year":"2015","journal-title":"J Virol"},{"issue":"2","key":"ppat.1012700.ref043","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/0042-6822(91)90584-X","article-title":"Infectious RNA transcripts from Ross River virus cDNA clones and the construction and characterization of defined chimeras with Sindbis virus","volume":"182","author":"RJ Kuhn","year":"1991","journal-title":"Virology"},{"issue":"21","key":"ppat.1012700.ref044","doi-asserted-by":"crossref","first-page":"9743","DOI":"10.1128\/JVI.01382-16","article-title":"The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling","volume":"90","author":"FS Varghese","year":"2016","journal-title":"J Virol"},{"issue":"12","key":"ppat.1012700.ref045","doi-asserted-by":"crossref","first-page":"e28923","DOI":"10.1371\/journal.pone.0028923","article-title":"Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays","volume":"6","author":"L Pohjala","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"ppat.1012700.ref046","doi-asserted-by":"crossref","first-page":"e0099324","DOI":"10.1128\/mbio.00993-24","article-title":"Exploring Barmah Forest virus pathogenesis: molecular tools to investigate non-structural protein 3 nuclear localization and viral genomic determinants of replication","volume":"15","author":"A Omler","year":"2024","journal-title":"mBio"},{"issue":"1","key":"ppat.1012700.ref047","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41467-024-44872-5","article-title":"LDLR is used as a cell entry receptor by multiple alphaviruses","volume":"15","author":"X Zhai","year":"2024","journal-title":"Nat Commun"},{"issue":"9","key":"ppat.1012700.ref048","doi-asserted-by":"crossref","first-page":"e02276","DOI":"10.1128\/JVI.02276-20","article-title":"Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral Replication","volume":"95","author":"M Teppor","year":"2021","journal-title":"J Virol"},{"issue":"8","key":"ppat.1012700.ref049","first-page":"e01788","article-title":"Identification of Natural Molecular Determinants of Ross River Virus Type I Interferon Modulation","volume":"94","author":"X Liu","year":"2020","journal-title":"J Virol"},{"issue":"1","key":"ppat.1012700.ref050","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00253-024-13168-5","article-title":"Development and application of a colloidal-gold immunochromatographic strip for detecting Getah virus antibodies","volume":"108","author":"Z Jiang","year":"2024","journal-title":"Appl Microbiol Biotechnol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012700","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T18:38:30Z","timestamp":1733855910000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012700"}},"subtitle":[],"editor":[{"given":"Julie","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":50,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012700","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.ppat.1012700","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}