{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:09:50Z","timestamp":1791670190874,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012747","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000}}],"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82370009"],"award-info":[{"award-number":["No.82370009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["No.2023YFC2412900 and No.2022YFC2704802"],"award-info":[{"award-number":["No.2023YFC2412900 and No.2022YFC2704802"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation Project of Chongqing","award":["No. CSTB2022NSCQ-LZX0017"],"award-info":[{"award-number":["No. CSTB2022NSCQ-LZX0017"]}]},{"name":"Chongqing Medical Scientific Research Project","award":["No. 2024ZDXM002"],"award-info":[{"award-number":["No. 2024ZDXM002"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistance of current antifungals. Here, we report that Trim72 positively regulates antifungal immunity during lethal fungal infection. Trim72 levels are significantly increased after\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infection. In vivo, Trim72 knockout significantly increases mortality, organ fungal burden and kidney damage in mice after lethal\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infection. Whereas recombinant Trim72 protein treatment protects mice against invasive candidiasis. Mechanistically, Trim72 facilitates macrophage infiltration and CCL2 production, which mediates Trim72-elicited protection against lethal\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infection. Furthermore, Trim72 may enhance macrophage migration and CCL2 production via NF-\u03baB and ERK1\/2 signaling. Inhibition of NF-\u03baB and ERK1\/2 signaling abrogates Trim72-mediated protection against lethal\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    infection. Therefore, these data imply that Trim72 may be developed as a host-directed therapy for treating severe systemic candidiasis.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012747","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T13:44:18Z","timestamp":1732542258000},"page":"e1012747","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Trim72 is a major host factor protecting against lethal Candida albicans infection"],"prefix":"10.1371","volume":"20","author":[{"given":"Wang","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renlin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-6986","authenticated-orcid":true,"given":"Ju","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ppat.1012747.ref001","first-page":"136130","article-title":"Essential functional modules for pathogenic and defensive mechanisms in Candida albicans infections.24757665; PubMed Central PMCID: PMC3976935.","volume":"2014","author":"YC Wang","year":"2014","journal-title":"BioMed research international"},{"issue":"4","key":"ppat.1012747.ref002","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/21505594.2015.1004977","article-title":"Adaptive immune responses to Candida albicans infection.","volume":"6","author":"JP Richardson","year":"2015","journal-title":"Virulence."},{"issue":"3","key":"ppat.1012747.ref003","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tim.2014.01.001","article-title":"A neglected epidemic: fungal infections in HIV\/AIDS","volume":"22","author":"D Armstrong-James","year":"2014","journal-title":"Trends in microbiology"},{"key":"ppat.1012747.ref004","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3389\/fmicb.2015.01322","article-title":"Optimizing Outcomes in Immunocompromised Hosts: Understanding the Role of Immunotherapy in Invasive Fungal Diseases.","volume":"6","author":"S Ravikumar","year":"2015","journal-title":"Frontiers in microbiology"},{"issue":"6","key":"ppat.1012747.ref005","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1097\/MOP.0000000000000031","article-title":"Primary immunodeficiencies underlying fungal infections","volume":"25","author":"F Lanternier","year":"2013","journal-title":"Current opinion in pediatrics"},{"issue":"1","key":"ppat.1012747.ref006","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4161\/viru.26187","article-title":"Invasive candidiasis as a cause of sepsis in the critically ill patient.","volume":"5","author":"J Delaloye","year":"2014","journal-title":"Virulence."},{"issue":"3","key":"ppat.1012747.ref007","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. 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