{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:20:54Z","timestamp":1793830854709,"version":"4.6.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012815","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071664"],"award-info":[{"award-number":["82071664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Human cytomegalovirus (HCMV) is a herpes virus with a long replication cycle. HCMV encoded long non-coding RNA termed RNA2.7 is the dominant transcript with a length of about 2.5kb, accounting for 25% of total viral transcripts. Studies have shown that HCMV RNA2.7 inhibits apoptosis caused by infection. The effect of RNA2.7 on other forms of cell death is still unclear. In this work, we found that RNA2.7 deletion significantly decreased the viability of HCMV-infected cells, while treatment with ferroptosis inhibitor Fer-1 rescued the infection-induced cell death, demonstrating an anti-ferroptosis role of RNA2.7. The results further showed that RNA2.7 inhibited ferroptosis via enhancing Ferritin Heavy Chain 1 (FTH1) and Solute Carrier Family 7 Member 11 (SLC7A11) expression in Erastin treated cells without involving other viral components. Pooled Genome-wide CRISPR screening revealed zinc finger protein 395 (ZNF395) as a new regulator repressing the expression of FTH1 and SLC7A11. HCMV RNA2.7 promoted proteasome-mediated degradation of ZNF395 that resulted in upregulation of FTH1 and SLC7A11 to inhibit ferroptosis, therefore maintain survival in host cells and complete replication of virus.<\/jats:p>","DOI":"10.1371\/journal.ppat.1012815","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T18:40:02Z","timestamp":1735238402000},"page":"e1012815","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human cytomegalovirus RNA2.7 inhibits ferroptosis by upregulating ferritin and GSH via promoting ZNF395 degradation"],"prefix":"10.1371","volume":"20","author":[{"given":"Mingyi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-8002","authenticated-orcid":true,"given":"Yujing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"3","key":"ppat.1012815.ref001","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/jmv.24989","article-title":"Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China","volume":"90","author":"L Wen","year":"2018","journal-title":"J Med Virol"},{"issue":"12","key":"ppat.1012815.ref002","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41579-021-00582-z","article-title":"Pathogenesis of human cytomegalovirus in the immunocompromised host","volume":"19","author":"P Griffiths","year":"2021","journal-title":"Nat Rev Microbiol"},{"issue":"2","key":"ppat.1012815.ref003","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41577-019-0225-5","article-title":"Modulation of innate and adaptive immunity by cytomegaloviruses","volume":"20","author":"R Berry","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"ppat.1012815.ref004","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/path.4437","article-title":"The pathogenesis of human cytomegalovirus","volume":"235","author":"P Griffiths","year":"2015","journal-title":"J Pathol"},{"issue":"4","key":"ppat.1012815.ref005","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/rmv.535","article-title":"Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection.","volume":"17","author":"A Kenneson","year":"2007","journal-title":"Rev Med Virol."},{"issue":"4","key":"ppat.1012815.ref006","first-page":"45","article-title":"Primary Human Cytomegalovirus (HCMV) Infection in Pregnancy.","volume":"114","author":"H Buxmann","year":"2017","journal-title":"Dtsch Arztebl Int"},{"issue":"5","key":"ppat.1012815.ref007","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"SC Dollard","year":"2007","journal-title":"Rev Med Virol"},{"key":"ppat.1012815.ref008","first-page":"661","article-title":"Tuning the Orchestra","volume":"11","author":"V Dell\u2019Oste","year":"2020","journal-title":"HCMV vs. Innate Immunity. 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