{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:25:22Z","timestamp":1791998722425,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012849","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000}}],"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI007538"],"award-info":[{"award-number":["T32AI007538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103451"],"award-info":[{"award-number":["P20GM103451"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Orthohantaviruses are negative-sense RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in humans. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS, with a fatality rate of 36% and most cases occuring in the southwestern states. The western deer mouse,\n                      <jats:italic>Peromyscus sonoriensis<\/jats:italic>\n                      , is the primary reservoir for SNV; however, it remains unclear if alternative reservoirs exist.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We conducted an extensive survey of SNV genetic prevalence in wild-caught small mammal communities throughout New Mexico and observed that 27% of all animals were positive for SNV. Through longitudinal trapping at a site of patient exposure, we found that SNV circulates at a high rate in multiple species over time. Furthermore, we isolated live SNV from tissues and feces from multiple small mammal species, demonstrating infectious virus in alternative and novel reservoirs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>Altogether, this work shows that SNV is widely prevalent and persistent throughout New Mexico in multiple small mammal reservoirs that can harbor and shed infectious virus. This encourages future work for additional surviellance efforts and revaluates host-species dynamics for New World hantaviruses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.ppat.1012849","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T13:28:17Z","timestamp":1737466097000},"page":"e1012849","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs"],"prefix":"10.1371","volume":"21","author":[{"given":"Samuel M.","family":"Goodfellow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Nofchissey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaecy K.","family":"Banther-McConnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanchira","family":"Suriyamongkol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Dunnum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Mali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-751X","authenticated-orcid":true,"given":"Steven B.","family":"Bradfute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"ppat.1012849.ref001","first-page":"15","article-title":"Zoonotic Hantaviridae with Global Public Health Significance.","author":"RX Chen","year":"2023","journal-title":"Viruses"},{"key":"ppat.1012849.ref002","article-title":"Hantavirus pulmonary syndrome: A clinical description of 17 patients with a newly recognized disease","author":"JS Duchin","year":"1994","journal-title":"New England Journal of 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Nombre Hantavirus in the Deer Mouse (Peromyscus maniculatus) Model.","volume":"76","author":"J Botten","year":"2002","journal-title":"J Virol"},{"key":"ppat.1012849.ref007","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4269\/ajtmh.1998.59.58","article-title":"Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus","volume":"59","author":"KL Hutchinson","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ppat.1012849.ref008","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/iai.31.1.334-338.1981","article-title":"Propagation of Korean hemorrhagic fever virus in laboratory rats","volume":"31","author":"P Woo Lee","year":"1981","journal-title":"Infect Immun"},{"key":"ppat.1012849.ref009","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/bs.aivir.2019.07.002","article-title":"Hantavirus entry: Perspectives and recent advances","volume":"104","author":"E Mittler","year":"2019","journal-title":"Adv Virus Res"},{"key":"ppat.1012849.ref010","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1016\/S1473-3099(23)00128-7","article-title":"Hantavirus in humans: a review of clinical aspects and management","volume":"23","author":"PA Vial","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"ppat.1012849.ref011","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2307\/1375053","article-title":"Growth in the Deer-Mouse, Peromyscus Maniculatus.","volume":"23","author":"LR Dice","year":"1942","journal-title":"J Mammal"},{"key":"ppat.1012849.ref012","first-page":"334","article-title":"CHROMOSOMAL HOMOLOGY AND DIVERGENCE BETWEEN SIBLING SPECIES OF DEER MICE: PEROMYSCUS MANICULATUS AND P.","volume":"32","author":"IF Greenbaum","year":"1978","journal-title":"MELANOTIS (RODENTIA, CRICETIDAE). Evolution"},{"key":"ppat.1012849.ref013","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/infdis\/169.6.1271","article-title":"Serologic and genetic identification of peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern united states","volume":"169","author":"JE Childs","year":"1994","journal-title":"Journal of Infectious Diseases"},{"key":"ppat.1012849.ref014","first-page":"1","author":"New Mexico Department of Health HCPS Cases by County 1975\u20132020","year":"2020","journal-title":"New Mexico Department of Health"},{"key":"ppat.1012849.ref015","doi-asserted-by":"crossref","first-page":"986","DOI":"10.7589\/2018-11-272","article-title":"Detection of new world hantavirus antibodies in rodents of eastern New Mexico, USA","volume":"55","author":"JL Curtis","year":"2019","journal-title":"J Wildl Dis"},{"key":"ppat.1012849.ref016","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/v15061313","article-title":"Multiple Lineages of Hantaviruses Harbored by the Iberian Mole (Talpa occidentalis) in Spain.","volume":"15","author":"SH Gu","year":"2023","journal-title":"Viruses"},{"key":"ppat.1012849.ref017","doi-asserted-by":"crossref","first-page":"e0296718","DOI":"10.1371\/journal.pone.0296718","article-title":"Distribution and prevalence of Sin Nombre hantavirus in rodent species in eastern New Mexico.","volume":"19","author":"JK Banther-McConnell","year":"2024","journal-title":"PLoS One."},{"key":"ppat.1012849.ref018","first-page":"95","article-title":"Tracing Transmission of Sin Nombre Virus and Discovery of Infection in Multiple Rodent Species","author":"SM Goodfellow","year":"2021","journal-title":"J Virol"},{"key":"ppat.1012849.ref019","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3201\/eid2809.220509","article-title":"Experimental Infection of Peromyscus Species Rodents with Sin Nombre Virus","volume":"28","author":"K Quizon","year":"2022","journal-title":"Emerg Infect Dis"},{"key":"ppat.1012849.ref020","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4269\/ajtmh.1998.58.525","article-title":"A survey of hantavirus antibody in small-mammal populations in selected United States National Parks","volume":"58","author":"JN Mills","year":"1998","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"ppat.1012849.ref021","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3201\/eid0501.990116","article-title":"Long-term studies of hantavirus reservoir populations in the southwestern United States: A synthesis","volume":"5","author":"JN Mills","year":"1999","journal-title":"Emerg Infect Dis"},{"key":"ppat.1012849.ref022","article-title":"Biospecimen Repositories and Integrated Databases as Critical Infrastructure for Pathogen Discovery and Pathobiology Research.","author":"JL 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A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. Database: Dryad; [Internet]. Available from https:\/\/doi.org.10.5061\/dryad.2547d7x2c"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012849","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T13:54:27Z","timestamp":1738331667000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012849"}},"subtitle":[],"editor":[{"given":"Amy L.","family":"Hartman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012849","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]}}}