{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:35:19Z","timestamp":1793140519907,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012879","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000}}],"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI150181"],"award-info":[{"award-number":["R01AI150181"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI136529"],"award-info":[{"award-number":["R01AI136529"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI152499"],"award-info":[{"award-number":["R21AI152499"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI171093"],"award-info":[{"award-number":["R01AI171093"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI156104"],"award-info":[{"award-number":["R21AI156104"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","award":["BroadIgnite"],"award-info":[{"award-number":["BroadIgnite"]}],"id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK043351"],"award-info":[{"award-number":["P30DK043351"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK135043"],"award-info":[{"award-number":["P30DK135043"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Microbial pathogens generate extracellular vesicles (EVs) for intercellular communication and quorum sensing. Microbial EVs also induce inflammatory pathways within host innate immune cells. We previously demonstrated that EVs secreted by\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    trigger type I interferon signaling in host cells specifically via the cGAS-STING innate immune signaling pathway. Here, we show that despite sharing similar properties of morphology and internal DNA content, the interactions between EVs and the innate immune system differ according to the parental fungal species. EVs secreted by\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ,\n                    <jats:italic>Saccharomyces cerevisiae, Cryptococcus neoformans,<\/jats:italic>\n                    and\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    are differentially endocytosed by murine macrophages triggering varied cytokine responses, innate immune signaling, and subsequent immune cell recruitment. Notably, polysaccharide and hydrophobic protein structures on the outer layers of\n                    <jats:italic>C. neoformans<\/jats:italic>\n                    and\n                    <jats:italic>A. fumigatus<\/jats:italic>\n                    EVs inhibit efficient internalization by macrophages and dampen innate immune activation. Our data uncover the functional consequences of the internalization of diverse fungal EVs by immune cells and reveal novel insights into the early innate immune response to distinct clinically significant fungal pathogens.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012879","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T13:47:57Z","timestamp":1748612877000},"page":"e1012879","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Extracellular vesicles from diverse fungal pathogens induce species-specific and endocytosis-dependent immunomodulation"],"prefix":"10.1371","volume":"21","author":[{"given":"Geneva N.","family":"Kwaku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine Nolling","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Simaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Floyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph W.","family":"Saelens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Basham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia W.","family":"Hepworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy D.","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Zamith-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Nosanchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatin M.","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9175-8209","authenticated-orcid":true,"given":"Hannah","family":"Brown Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ppat.1012879.ref001","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-023-00926-2","article-title":"Diagnosis of invasive fungal infections: challenges and recent developments","volume":"30","author":"W Fang","year":"2023","journal-title":"Journal of Biomedical Science"},{"key":"ppat.1012879.ref002","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11041063","article-title":"Antifungal Drug Resistance: An Emergent Health Threat","volume":"11","author":"A Vitiello","year":"2023","journal-title":"Biomedicines"},{"issue":"8","key":"ppat.1012879.ref003","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010740","article-title":"Type i interferons during host fungus interactions: Is antifungal immunity going viral?","volume":"18","author":"M Pekmezovic","year":"2022","journal-title":"PLoS Pathog"},{"issue":"5","key":"ppat.1012879.ref004","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41564-021-00875-2","article-title":"Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells","volume":"6","author":"M Pekmezovic","year":"2021","journal-title":"Nat Microbiol"},{"key":"ppat.1012879.ref005","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/ncomms2343","article-title":"Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans","volume":"4","author":"SP Smeekens","year":"2013","journal-title":"Nat Commun"},{"issue":"8","key":"ppat.1012879.ref006","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.immuni.2023.06.002","article-title":"The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity","volume":"56","author":"T Chen","year":"2023","journal-title":"Immunity"},{"key":"ppat.1012879.ref007","article-title":"The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis","volume":"202","author":"F Han","year":"2021","journal-title":"Exp Eye Res"},{"key":"ppat.1012879.ref008","article-title":"The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity","volume":"12","author":"N Liu","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"15","key":"ppat.1012879.ref009","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.15252\/embj.201488029","article-title":"Listeria monocytogenes induces IFN\u03b2 expression through an IFI16-, cGAS- and STING-dependent pathway","volume":"33","author":"K Hansen","year":"2014","journal-title":"EMBO J"},{"issue":"11","key":"ppat.1012879.ref010","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.celrep.2016.05.030","article-title":"Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4","volume":"15","author":"WA Andrade","year":"2016","journal-title":"Cell Rep"},{"issue":"6","key":"ppat.1012879.ref011","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102519","article-title":"Activation of cGAS\/STING pathway upon paramyxovirus infection","volume":"24","author":"M Iampietro","year":"2021","journal-title":"iScience"},{"key":"ppat.1012879.ref012","article-title":"The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy","volume":"15","author":"K Zhang","year":"2024","journal-title":"Frontiers in Immunology"},{"issue":"7899","key":"ppat.1012879.ref013","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41586-022-04421-w","article-title":"The cGAS-STING pathway drives type I IFN immunopathology in COVID-19","volume":"603","author":"JD Domizio","year":"2022","journal-title":"Nature"},{"issue":"1","key":"ppat.1012879.ref014","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41564-023-01546-0","article-title":"Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING","volume":"9","author":"H Brown Harding","year":"2024","journal-title":"Nat Microbiol"},{"issue":"2","key":"ppat.1012879.ref015","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches","volume":"13","author":"JA Welsh","year":"2024","journal-title":"J Extracell Vesicles"},{"issue":"6","key":"ppat.1012879.ref016","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"H Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ppat.1012879.ref017","doi-asserted-by":"crossref","first-page":"100043","DOI":"10.1016\/j.vesic.2024.100043","article-title":"Host innate immune systems gather intel on invading microbes via pathogen-derived extracellular vesicles","volume":"3","author":"GN Kwaku","year":"2024","journal-title":"Extracell Vesicle"},{"issue":"1","key":"ppat.1012879.ref018","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-019-0538-8","article-title":"Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling","volume":"2","author":"K Zhao","year":"2019","journal-title":"Commun Biol"},{"issue":"2","key":"ppat.1012879.ref019","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.xphs.2022.08.032","article-title":"Functional Characterization of Extracellular Vesicles from Baker\u2019s Yeast Saccharomyces Cerevisiae as a Novel Vaccine Material for Immune Cell Maturation","volume":"112","author":"A Higuchi","year":"2023","journal-title":"J Pharm Sci"},{"issue":"2","key":"ppat.1012879.ref020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1080\/1040841X.2020.1869178","article-title":"Cryptococcus neoformans-astrocyte interactions: effect on fungal blood brain barrier disruption, brain invasion, and meningitis progression","volume":"47","author":"YH Woo","year":"2021","journal-title":"Crit Rev Microbiol"},{"issue":"1","key":"ppat.1012879.ref021","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1080\/21505594.2018.1431087","article-title":"The capsule of Cryptococcus neoformans","volume":"10","author":"A Casadevall","year":"2019","journal-title":"Virulence"},{"issue":"4","key":"ppat.1012879.ref022","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/IAI.01171-09","article-title":"Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions","volume":"78","author":"DL Oliveira","year":"2010","journal-title":"Infect Immun"},{"key":"ppat.1012879.ref023","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcsw.2019.100023","article-title":"Assembly and disassembly of Aspergillus fumigatus conidial rodlets","volume":"5","author":"I Valsecchi","year":"2019","journal-title":"Cell Surface"},{"key":"ppat.1012879.ref024","article-title":"Characterization of Aspergillus fumigatus extracellular vesicles and their effects on macrophages and neutrophils functions","volume":"10","author":"JAM Souza","year":"2019","journal-title":"Front Microbiol"},{"issue":"5","key":"ppat.1012879.ref025","doi-asserted-by":"crossref","DOI":"10.3390\/jof9050541","article-title":"Aspergillus fumigatus extracellular vesicles display increased Galleria mellonella survival but partial pro-inflammatory response by macrophages","volume":"9","author":"MS Freitas","year":"2023","journal-title":"Journal of Fungi"},{"key":"ppat.1012879.ref026","first-page":"77","article-title":"Use of Dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis","volume-title":"Methods in Enzymology","author":"T Kirchhausen","year":"2008"},{"key":"ppat.1012879.ref027","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5787","article-title":"Microfluidic platform for the quantitative analysis of leukocyte migration signatures","volume":"5","author":"L Boneschansker","year":"2014","journal-title":"Nat Commun"},{"key":"ppat.1012879.ref028","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47491","article-title":"Tight nuclear tethering of cGAS is essential for preventing autoreactivity","volume":"8","author":"HE Volkman","year":"2019","journal-title":"Elife"},{"issue":"1","key":"ppat.1012879.ref029","article-title":"A nuclear export signal is required for cGAS to sense cytosolic DNA","volume":"34","author":"H Sun","year":"2021","journal-title":"Cell Rep"},{"key":"ppat.1012879.ref030","author":"K Mosallanejad","year":"2022"},{"issue":"1","key":"ppat.1012879.ref031","article-title":"Nuclear soluble cGAS senses double-stranded DNA virus infection","volume":"5","author":"Y Wu","year":"2022","journal-title":"Commun Biol"},{"issue":"1","key":"ppat.1012879.ref032","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-26525-z","article-title":"Coordination of fungal biofilm development by extracellular vesicle cargo","volume":"12","author":"R Zarnowski","year":"2021","journal-title":"Nat Commun"},{"key":"ppat.1012879.ref033","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00738","article-title":"Extracellular vesicle heterogeneity: Subpopulations, isolation techniques, and diverse functions in cancer progression","volume":"9","author":"E Willms","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"ppat.1012879.ref034","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41596-020-00466-1","article-title":"Isolation and characterization of extracellular vesicle subpopulations from tissues","volume":"16","author":"R Crescitelli","year":"2021","journal-title":"Nat Protoc"},{"key":"ppat.1012879.ref035","first-page":"804","article-title":"Overview and Update on Extracellular Vesicles: Considerations on Exosomes and Their Application in Modern Medicine.","author":"MA Di Bella","year":"2022","journal-title":"Biology (Basel) [Internet]"},{"issue":"3","key":"ppat.1012879.ref036","article-title":"The role of transcript regions and amino acid choice in nucleosome positioning","volume":"5","author":"M Yadav","year":"2023","journal-title":"NAR Genom Bioinform"},{"issue":"2","key":"ppat.1012879.ref037","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100824","article-title":"Sensitive Automated Measurement of Histone-DNA Affinities in Nucleosomes","volume":"23","author":"M Schnepf","year":"2020","journal-title":"iScience"},{"issue":"4","key":"ppat.1012879.ref038","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/yea.3701","article-title":"GC content strongly influences the role of poly(dA) in the intrinsic nucleosome positioning in Saccharomyces cerevisiae","volume":"39","author":"E Trotta","year":"2022","journal-title":"Yeast"},{"key":"ppat.1012879.ref039","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-442","article-title":"G C content dominates intrinsic nucleosome occupancy","volume":"10","author":"D Tillo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"ppat.1012879.ref040","author":"T Jones","year":"2004"},{"key":"ppat.1012879.ref041","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0076-6879(10)70033-1","article-title":"Applying genetics and molecular biology to the study of the human pathogen Cryptococcus neoformans","volume":"470","author":"CD Chun","year":"2010","journal-title":"Methods Enzymol"},{"issue":"7071","key":"ppat.1012879.ref042","doi-asserted-by":"crossref","DOI":"10.1038\/nature04332","article-title":"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus","volume":"438","author":"WC Nierman","year":"2005","journal-title":"Nature"},{"issue":"1","key":"ppat.1012879.ref043","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1128\/EC.00370-07","article-title":"Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence","volume":"7","author":"ML Rodrigues","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ppat.1012879.ref044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pathogens9090754","article-title":"Pathogenic delivery: The biological roles of cryptococcal extracellular vesicles","volume":"9","author":"HC de Oliveira","year":"2020","journal-title":"Pathogens"},{"issue":"7","key":"ppat.1012879.ref045","first-page":"4912","article-title":"Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence","volume":"14","author":"YC Chang","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ppat.1012879.ref046","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-1119(95)00640-0","article-title":"Further analysis of the CAP59 locus of Cryptococcus neoformans: structure defined by forced expression and description of a new ribosomal protein-encoding gene","volume":"167","author":"YC Chang","year":"1995","journal-title":"Gene"},{"issue":"6","key":"ppat.1012879.ref047","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1462-5822.2008.01125.x","article-title":"Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand","volume":"10","author":"SN Villena","year":"2008","journal-title":"Cell Microbiol"},{"issue":"10","key":"ppat.1012879.ref048","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.4049\/jimmunol.0803833","article-title":"Involvement of glycoreceptors in galactoxylomannan-induced T cell death","volume":"182","author":"E Pericolini","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"ppat.1012879.ref049","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1462-5822.2005.00619.x","article-title":"Cryptococcus neoformans capsular polysaccharide component galactoxylomannan induces apoptosis of human T-cells through activation of caspase-8","volume":"8","author":"E Pericolini","year":"2006","journal-title":"Cell Microbiol"},{"issue":"2","key":"ppat.1012879.ref050","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2174\/0929867043456188","article-title":"Effects of the capsular polysaccharides of Cryptococcus neoformans on phagocyte migration and inflammatory mediators","volume":"11","author":"PM Ellerbroek","year":"2004","journal-title":"Curr Med Chem"},{"issue":"5","key":"ppat.1012879.ref051","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1128\/iai.65.5.1836-1841.1997","article-title":"Cellular charge of Cryptococcus neoformans: contributions from the capsular polysaccharide, melanin, and monoclonal antibody binding","volume":"65","author":"JD Nosanchuk","year":"1997","journal-title":"Infect Immun"},{"key":"ppat.1012879.ref052","doi-asserted-by":"crossref","first-page":"8008","DOI":"10.1038\/srep08008","article-title":"Capsular polysaccharides from Cryptococcus neoformans modulate production of neutrophil extracellular traps (NETs) by human neutrophils","volume":"5","author":"JDB Rocha","year":"2015","journal-title":"Sci Rep"},{"issue":"7259","key":"ppat.1012879.ref053","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores","volume":"460","author":"V Aimanianda","year":"2009","journal-title":"Nature"},{"issue":"5","key":"ppat.1012879.ref054","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.1300748","article-title":"The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo","volume":"191","author":"J Carrion S de","year":"2013","journal-title":"J Immunol"},{"key":"ppat.1012879.ref055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2023.107039","article-title":"Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains","volume":"299","author":"K Kawano","year":"2023","journal-title":"Biophys Chem"},{"key":"ppat.1012879.ref056","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.607945","article-title":"Modulation of Immune Responses by Particle Size and Shape","volume":"11","author":"MV Baranov","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"11","key":"ppat.1012879.ref057","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.micres.2014.02.013","article-title":"Fungal invasion of epithelial cells","volume":"169","author":"W Yang","year":"2014","journal-title":"Microbiol Res"},{"issue":"8","key":"ppat.1012879.ref058","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016972","article-title":"Endocytosis of viruses and bacteria","volume":"6","author":"P Cossart","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"4","key":"ppat.1012879.ref059","doi-asserted-by":"crossref","DOI":"10.1189\/jlb.1009651","article-title":"Inhibition of dynamin-dependent endocytosis interferes with type III IFN expression in bacteria-infected human monocyte-derived DCs","volume":"88","author":"TE Pietil\u00e4","year":"2010","journal-title":"J Leukoc Biol"},{"issue":"4","key":"ppat.1012879.ref060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/ni1569","article-title":"TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta","volume":"9","author":"JC Kagan","year":"2008","journal-title":"Nat Immunol"},{"issue":"1","key":"ppat.1012879.ref061","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12964-015-0102-1","article-title":"Dynasore - not just a dynamin inhibitor","volume":"13","author":"G Preta","year":"2015","journal-title":"Cell Communication and Signaling"},{"issue":"10","key":"ppat.1012879.ref062","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Q Chen","year":"2016","journal-title":"Nat Immunol"},{"issue":"43","key":"ppat.1012879.ref063","article-title":"Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune response","volume":"119","author":"Y-L Yang","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ppat.1012879.ref064","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41401-023-01185-5","article-title":"The role of the cGAS-STING signaling pathway in viral infections, inflammatory and autoimmune diseases","volume":"45","author":"ming Wang M","year":"2024","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"ppat.1012879.ref065","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.cell.2019.01.049","article-title":"Phosphoinositide interactions position cGAS at the plasma membrane to ensure efficient distinction between self- and viral DNA","volume":"176","author":"KC Barnett","year":"2019","journal-title":"Cell"},{"issue":"7","key":"ppat.1012879.ref066","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.4049\/jimmunol.2100599","article-title":"TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils","volume":"208","author":"AL Viens","year":"2022","journal-title":"J Immunol"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1012879","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000}},{"DOI":"10.1371\/journal.ppat.1014029","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T14:03:38Z","timestamp":1749650618000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1012879"}},"subtitle":[],"editor":[{"given":"Gustavo Henrique","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":66,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1012879","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.03.631181","asserted-by":"object"}]},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]}}}