{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:10:28Z","timestamp":1792044628316,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1012900","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007163"],"award-info":[{"award-number":["T32 AI007163"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM007200"],"award-info":[{"award-number":["T32 GM007200"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI173360"],"award-info":[{"award-number":["R01 AI173360"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Investigator in the Pathogenesis of Infectious Disease"],"award-info":[{"award-number":["Investigator in the Pathogenesis of Infectious Disease"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35 GM152192"],"award-info":[{"award-number":["R35 GM152192"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Autophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role in Orsay virus infection of\n                    <jats:italic>Caenorhabditis elegans.<\/jats:italic>\n                    Orsay virus infection does not modulate autophagic flux, and re-feeding after starvation limits Orsay virus infection and blocks autophagic flux, suggesting that the role of ATG-3 in Orsay virus susceptibility is independent of its role in maintaining autophagic flux.\n                    <jats:italic>atg-3<\/jats:italic>\n                    mutants phenocopy\n                    <jats:italic>rde-1<\/jats:italic>\n                    mutants, which have a defect in RNA interference (RNAi), in susceptibility to Orsay virus infection and transcriptional response to infection. However,\n                    <jats:italic>atg-3<\/jats:italic>\n                    mutants do not exhibit defects in RNAi. Additionally, ATG-3 limits viral infection at a post-entry step, similar to RDE-1. Differential expression analysis using RNA sequencing revealed that antiviral\n                    <jats:italic>sqt-2<\/jats:italic>\n                    , which encodes a collagen trimer protein, is depleted in mock-infected and infected\n                    <jats:italic>atg-3<\/jats:italic>\n                    mutants, as well as in infected WT animals, as are numerous other collagen genes. These data suggest that ATG-3 may have a role in collagen organization pathways that function in antiviral defense in\n                    <jats:italic>C. elegans<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1012900","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T18:34:41Z","timestamp":1763490881000},"page":"e1012900","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["ATG-3 limits Orsay virus infection in C. elegans and regulates collagen pathways"],"prefix":"10.1371","volume":"21","author":[{"given":"Gowri","family":"Kalugotla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Marmerstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Schriefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Casorla","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Schedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-6131","authenticated-orcid":true,"given":"Megan T.","family":"Baldridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"issue":"7","key":"ppat.1012900.ref001","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nrm2708","article-title":"Dynamics and diversity in autophagy mechanisms: lessons from yeast","volume":"10","author":"H Nakatogawa","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"ppat.1012900.ref002","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"B Levine","year":"2008","journal-title":"Cell"},{"issue":"7330","key":"ppat.1012900.ref003","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature09782","article-title":"Autophagy in immunity and inflammation","volume":"469","author":"B 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