{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:50:23Z","timestamp":1790848223087,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1P20GM152333-01"],"award-info":[{"award-number":["1P20GM152333-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1013067","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T13:22:27Z","timestamp":1745328147000},"page":"e1013067","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Achromobacter spp.: Emerging pathogens in the cystic fibrosis lung"],"prefix":"10.1371","volume":"21","author":[{"given":"Niladri","family":"Bhowmik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-3272","authenticated-orcid":true,"given":"Reed M.","family":"Stubbendieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"5","key":"ppat.1013067.ref001","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1348-0421.1971.tb00607.x","article-title":"Achromobacter xylosoxidans n. sp. from human ear discharge","volume":"15","author":"E Yabuuchi","year":"1971","journal-title":"Jpn J Microbiol"},{"issue":"4","key":"ppat.1013067.ref002","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1099\/00207713-24-4-470","article-title":"Description of Achromobacter xylosoxidans Yabuuchi and Ohyama 1971","volume":"24","author":"E Yabuuchi","year":"1974","journal-title":"Int J Syst Bacteriol"},{"issue":"4","key":"ppat.1013067.ref003","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1099\/00207713-31-4-477","article-title":"Achromobacter gen. nov. and Achromobacter xylosoxidans (ex Yabuuchi and Ohyama 1971) nom. rev","volume":"31","author":"E Yabuuchi","year":"1981","journal-title":"Int J Syst Bacteriol"},{"issue":"2","key":"ppat.1013067.ref004","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ppul.10143","article-title":"Alcaligenes infection in cystic fibrosis","volume":"34","author":"K Tan","year":"2002","journal-title":"Pediatr Pulmonol"},{"issue":"6","key":"ppat.1013067.ref005","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jcf.2011.07.004","article-title":"Marked increase in incidence of Achromobacter xylosoxidans infections caused by sporadic acquisition from the environment","volume":"10","author":"W Ridderberg","year":"2011","journal-title":"J Cyst Fibros"},{"issue":"9","key":"ppat.1013067.ref006","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1513\/AnnalsATS.201701-071OC","article-title":"Clinical outcomes associated with Achromobacter species infection in patients with cystic fibrosis","volume":"14","author":"R Somayaji","year":"2017","journal-title":"Ann Am Thorac Soc"},{"issue":"2","key":"ppat.1013067.ref007","doi-asserted-by":"crossref","first-page":"00076","DOI":"10.1183\/23120541.00076-2021","article-title":"Achromobacter xylosoxidans airway infection is associated with lung disease severity in children with cystic fibrosis","volume":"7","author":"C Marsac","year":"2021","journal-title":"ERJ Open Res"},{"issue":"6","key":"ppat.1013067.ref008","doi-asserted-by":"crossref","first-page":"e0242221","DOI":"10.1128\/jcm.02422-21","article-title":"Distribution of Achromobacter species in 12 French Cystic Fibrosis Centers in 2020 by a retrospective MALDI-TOF MS spectrum analysis","volume":"60","author":"T Garrigos","year":"2022","journal-title":"J Clin Microbiol"},{"key":"ppat.1013067.ref009","doi-asserted-by":"crossref","first-page":"127140","DOI":"10.1016\/j.micres.2022.127140","article-title":"Achromobacter spp. prevalence and adaptation in cystic fibrosis lung infection","volume":"263","author":"L Veschetti","year":"2022","journal-title":"Microbiol Res"},{"issue":"8","key":"ppat.1013067.ref010","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s10096-011-1182-5","article-title":"Achromobacter xylosoxidans respiratory tract infection in cystic fibrosis patients","volume":"30","author":"A Lambiase","year":"2011","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"7","key":"ppat.1013067.ref011","first-page":"000606","article-title":"Genomic characterization of Achromobacter species isolates from chronic and occasional lung infection in cystic fibrosis patients","volume":"7","author":"L Veschetti","year":"2021","journal-title":"Microb Genom"},{"key":"ppat.1013067.ref012","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/jpids\/piac052","article-title":"Opportunistic pathogens in cystic fibrosis: epidemiology and pathogenesis of lung infection","volume":"11","author":"AC Blanchard","year":"2022","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"9","key":"ppat.1013067.ref013","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1600-0463.2008.00995.x","article-title":"Achromobacter xylosoxidans respiratory tract infections in cystic fibrosis patients","volume":"116","author":"T Raso","year":"2008","journal-title":"APMIS"},{"issue":"4","key":"ppat.1013067.ref014","doi-asserted-by":"crossref","first-page":"e02911-20","DOI":"10.1128\/JCM.02911-20","article-title":"Transmission and antibiotic resistance of achromobacter in cystic fibrosis","volume":"59","author":"M Gabrielaite","year":"2021","journal-title":"J Clin Microbiol"},{"issue":"3","key":"ppat.1013067.ref015","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jcf.2012.10.002","article-title":"Identification and distribution of Achromobacter species in cystic fibrosis","volume":"12","author":"T Spilker","year":"2013","journal-title":"J Cyst Fibros"},{"issue":"4","key":"ppat.1013067.ref016","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/gbe\/evx061","article-title":"A pan-genomic approach to understand the basis of host adaptation in Achromobacter","volume":"9","author":"J Jeukens","year":"2017","journal-title":"Genome Biol Evol"},{"issue":"4","key":"ppat.1013067.ref017","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jcf.2006.04.002","article-title":"Chronic infection with Achromobacter xylosoxidans in cystic fibrosis patients; a retrospective case control study","volume":"5","author":"C R\u00f8nne Hansen","year":"2006","journal-title":"J Cyst Fibros"},{"issue":"1","key":"ppat.1013067.ref018","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jcf.2009.10.005","article-title":"Inflammation in Achromobacter xylosoxidans infected cystic fibrosis patients","volume":"9","author":"CR Hansen","year":"2010","journal-title":"J Cyst Fibros"},{"issue":"7","key":"ppat.1013067.ref019","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1099\/jmm.0.000763","article-title":"Effect of respiratory Achromobacter spp. infection on pulmonary function in patients with cystic fibrosis","volume":"67","author":"R Recio","year":"2018","journal-title":"J Med Microbiol"},{"issue":"4","key":"ppat.1013067.ref020","doi-asserted-by":"crossref","first-page":"00051","DOI":"10.1183\/23120541.00051-2019","article-title":"Impact of Achromobacter xylosoxidans isolation on the respiratory function of adult patients with cystic fibrosis","volume":"5","author":"M Tetart","year":"2019","journal-title":"ERJ Open Res"},{"issue":"3","key":"ppat.1013067.ref021","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ppul.25793","article-title":"Impact of Achromobacter spp. isolation on clinical outcomes in children with cystic fibrosis","volume":"57","author":"B Sunman","year":"2022","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"ppat.1013067.ref022","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jcf.2022.11.001","article-title":"Clinical outcomes associated with Achromobacter species infection in people with cystic fibrosis","volume":"22","author":"ECFSPR with the list of contributing authors.","year":"2023","journal-title":"J Cyst Fibros"},{"issue":"7","key":"ppat.1013067.ref023","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1128\/JCM.02556-16","article-title":"Prevalence and outcomes of Achromobacter species infections in adults with cystic fibrosis: a North American Cohort Study","volume":"55","author":"BD Edwards","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ppat.1013067.ref024","doi-asserted-by":"crossref","first-page":"e5097","DOI":"10.1590\/1414-431X20155097","article-title":"Clinical impact of Achromobacter xylosoxidans colonization\/infection in patients with cystic fibrosis","volume":"49","author":"MC Firmida","year":"2016","journal-title":"Braz J Med Biol Res"},{"issue":"12","key":"ppat.1013067.ref025","doi-asserted-by":"crossref","first-page":"e0041623","DOI":"10.1128\/iai.00416-23","article-title":"Pathogenesis of Achromobacter xylosoxidans respiratory infections: colonization, persistence, and transcriptome profiling in synthetic cystic fibrosis sputum medium","volume":"91","author":"CE Billiot","year":"2023","journal-title":"Infect Immun"},{"issue":"7","key":"ppat.1013067.ref026","doi-asserted-by":"crossref","first-page":"e0003723","DOI":"10.1128\/iai.00037-23","article-title":"Identification of virulence factors involved in a murine model of severe Achromobacter xylosoxidans infection","volume":"91","author":"BM Wills","year":"2023","journal-title":"Infect Immun"},{"issue":"7","key":"ppat.1013067.ref027","doi-asserted-by":"crossref","first-page":"e00136-20","DOI":"10.1128\/IAI.00136-20","article-title":"Achromobacter xylosoxidans cellular pathology is correlated with activation of a Type III secretion system","volume":"88","author":"AM Pickrum","year":"2020","journal-title":"Infect Immun"},{"issue":"4","key":"ppat.1013067.ref028","doi-asserted-by":"crossref","first-page":"e0208322","DOI":"10.1128\/spectrum.02083-22","article-title":"The in vitro replication cycle of Achromobacter xylosoxidans and identification of virulence genes associated with cytotoxicity in macrophages","volume":"10","author":"AM Pickrum","year":"2022","journal-title":"Microbiol Spectr"},{"issue":"8","key":"ppat.1013067.ref029","doi-asserted-by":"crossref","first-page":"113012","DOI":"10.1016\/j.celrep.2023.113012","article-title":"The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes","volume":"42","author":"K Turton","year":"2023","journal-title":"Cell Rep"},{"issue":"4","key":"ppat.1013067.ref030","doi-asserted-by":"crossref","first-page":"e0019523","DOI":"10.1128\/spectrum.00195-23","article-title":"Exoproducts of the most common Achromobacter species in cystic fibrosis evoke similar inflammatory responses in vitro","volume":"11","author":"C Sahl","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"16","key":"ppat.1013067.ref031","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/JB.00275-16","article-title":"Multifaceted interfaces of bacterial competition","volume":"198","author":"RM Stubbendieck","year":"2016","journal-title":"J Bacteriol"},{"issue":"4","key":"ppat.1013067.ref032","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1128\/IAI.68.4.1834-1839.2000","article-title":"Impact of siderophore production on Pseudomonas aeruginosa infections in immunosuppressed mice","volume":"68","author":"H Takase","year":"2000","journal-title":"Infect Immun"},{"key":"ppat.1013067.ref033","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.3389\/fmicb.2019.02048","article-title":"Pyoverdine-dependent virulence of Pseudomonas aeruginosa isolates from cystic fibrosis patients","volume":"10","author":"D Kang","year":"2019","journal-title":"Front Microbiol"},{"issue":"3","key":"ppat.1013067.ref034","doi-asserted-by":"crossref","first-page":"e0295323","DOI":"10.1128\/spectrum.02953-23","article-title":"Prevalence and variability of siderophore production in the Achromobacter genus","volume":"12","author":"P Sorlin","year":"2024","journal-title":"Microbiol Spectr"},{"issue":"1","key":"ppat.1013067.ref035","doi-asserted-by":"crossref","first-page":"e0210201","DOI":"10.1371\/journal.pone.0210201","article-title":"Clinical and microbiological characteristics of cystic fibrosis adults never colonized by Pseudomonas aeruginosa: analysis of the French CF registry","volume":"14","author":"R Vongthilath","year":"2019","journal-title":"PLoS One"},{"key":"ppat.1013067.ref036","article-title":"Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a multi-target mechanism of competition","author":"A Besse","year":"2025","journal-title":"Microbiology"},{"key":"ppat.1013067.ref037","doi-asserted-by":"crossref","first-page":"558160","DOI":"10.3389\/fmicb.2020.558160","article-title":"High occurrence of bacterial competition among clinically documented opportunistic pathogens including Achromobacter xylosoxidans in cystic fibrosis","volume":"11","author":"Q Menetrey","year":"2020","journal-title":"Front Microbiol"},{"issue":"11","key":"ppat.1013067.ref038","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1021\/acs.jnatprod.3c00536","article-title":"Discovery, characterization, and bioactivity of the achromonodins: lasso peptides encoded by Achromobacter","volume":"86","author":"DV Carson","year":"2023","journal-title":"J Nat Prod"},{"key":"ppat.1013067.ref039","doi-asserted-by":"crossref","first-page":"859181","DOI":"10.3389\/fcimb.2022.859181","article-title":"Characterization of the Achromobacter xylosoxidans Type VI secretion system and its implication in cystic fibrosis","volume":"12","author":"M Le Goff","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"ppat.1013067.ref040","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1513\/AnnalsATS.201406-288FR","article-title":"Achromobacter respiratory infections","volume":"12","author":"CE Swenson","year":"2015","journal-title":"Ann Am Thorac Soc"},{"issue":"1","key":"ppat.1013067.ref041","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000533923","article-title":"Green nail syndrome treated with ozenoxacin: two case reports","volume":"15","author":"T Cosio","year":"2023","journal-title":"Case Rep Dermatol"},{"key":"ppat.1013067.ref042","doi-asserted-by":"crossref","first-page":"e01211","DOI":"10.1016\/j.idcr.2021.e01211","article-title":"Chronic osteomyelitis caused by Achromobacter xylosoxidans following orthopaedic trauma: a case report and review of the literature","volume":"25","author":"S Imani","year":"2021","journal-title":"IDCases"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1013067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T13:22:34Z","timestamp":1745328154000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1013067"}},"subtitle":[],"editor":[{"given":"John M","family":"Leong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1013067","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]}}}