{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:12:47Z","timestamp":1792033967016,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013114","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000}}],"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI177604"],"award-info":[{"award-number":["1R01AI177604"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p><jats:italic>Candida auris<\/jats:italic> is an emerging multidrug-resistant skin-tropic fungal pathogen that causes serious human infections. However, the factors that regulate <jats:italic>C. auris<\/jats:italic> skin infection <jats:italic>in vivo<\/jats:italic> are still unclear. In this study, we identified that, unlike <jats:italic>Candida albicans,<\/jats:italic> which induces IL-17-secreting protective effector Th17 cells, <jats:italic>C. auris<\/jats:italic> predominately induces IFN\u03b3-secreting pathogenic Th1 cells during reinfection. Surprisingly, we found that IFN\u03b3 enhances skin infection of <jats:italic>C. auris<\/jats:italic> but not <jats:italic>C. albicans.<\/jats:italic> Mechanistically, IFN\u03b3 enhances skin infection of <jats:italic>C. auris<\/jats:italic> by dampening the protective IL-17 responses and increasing dermal damage. Furthermore, we identified that the development of Th1 cells occurs through IL-12, produced by <jats:italic>C. auris<\/jats:italic>-induced inflammatory macrophages and monocyte-derived dendritic cells. In addition, our findings reveal that <jats:italic>C. auris<\/jats:italic> unique cell wall outer mannan layer regulates the development of Th1 and Th17 cells. Collectively, our findings, for the first time, identified that <jats:italic>C. auris<\/jats:italic> induces IFN\u03b3 to persist in the skin. These findings help explain why <jats:italic>C. auris<\/jats:italic> but not <jats:italic>C. albicans<\/jats:italic> preferentially persist in the skin long-term, with the potential to identify novel therapeutic approaches to prevent and treat this emerging fungal pathogen in humans.<\/jats:p>","DOI":"10.1371\/journal.ppat.1013114","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T17:40:37Z","timestamp":1745862037000},"page":"e1013114","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Emerging Fungal Pathogen Candida auris Induces IFN\u03b3 to Colonize the Skin"],"prefix":"10.1371","volume":"21","author":[{"given":"Diprasom","family":"Das","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrihari 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