{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:50:39Z","timestamp":1792788639176,"version":"4.5.0"},"reference-count":14,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272306"],"award-info":[{"award-number":["82272306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College students innovation and entrepreneurship training program of Shandong province","award":["S202410439019"],"award-info":[{"award-number":["S202410439019"]}]},{"name":"Taishan Scholars Program","award":["tstp20221142"],"award-info":[{"award-number":["tstp20221142"]}]},{"name":"Joint Innovation Team for Clinical & Basic Research","award":["202409"],"award-info":[{"award-number":["202409"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Tecovirimat (ST-246 or TPOXX) is an antiviral agent developed as part of a U.S. biodefense initiative aimed at addressing\n                    <jats:italic>Orthopoxvirus<\/jats:italic>\n                    infections, including smallpox and mpox. Although smallpox was declared eradicated in 1980, the potential for its reemergence as a biothreat persists due to illegal stockpiling and the possibility of laboratory synthesis. The F13 protein, which plays a critical role in the formation of extracellular viral particles, serves as the primary target for tecovirimat, inhibiting the transition from intracellular mature viruses (IMVs) to intracellular enveloped viruses (IEVs). Recent research indicates that tecovirimat stabilizes F13 homodimers as a molecular glue, effectively disrupting viral wrapping processes. However, the identification of tecovirimat-resistant mutations, particularly in immunocompromised individuals, highlights the urgent need for ongoing monitoring and the development of next-generation antiviral therapies. Investigating the structural dynamics of F13 and its interactions with tecovirimat may provide crucial insights into overcoming resistance mechanisms and improving therapeutic efficacy.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013140","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:03:02Z","timestamp":1747411382000},"page":"e1013140","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Tecovirimat: A journey from discovery to mechanistic insights in poxvirus inhibition"],"prefix":"10.1371","volume":"21","author":[{"given":"Xue","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-9661","authenticated-orcid":true,"given":"Leiliang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"issue":"11","key":"ppat.1013140.ref001","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.3390\/v2112409","article-title":"Development of ST-246\u00ae for treatment of poxvirus infections","volume":"2","author":"R Jordan","year":"2010","journal-title":"Viruses"},{"key":"ppat.1013140.ref002","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.antiviral.2019.06.005","article-title":"The development and approval of tecoviromat (TPOXX\u00ae), the first antiviral against smallpox","volume":"168","author":"M Merchlinsky","year":"2019","journal-title":"Antiviral Res"},{"issue":"19","key":"ppat.1013140.ref003","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1001\/jama.2024.21091","article-title":"Mpox clinical presentation, diagnostic approaches, and treatment strategies: a review","volume":"332","author":"BK Titanji","year":"2024","journal-title":"JAMA"},{"issue":"20","key":"ppat.1013140.ref004","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1128\/JVI.79.20.13139-13149.2005","article-title":"An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge","volume":"79","author":"G Yang","year":"2005","journal-title":"J Virol"},{"issue":"6","key":"ppat.1013140.ref005","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/AAC.01689-09","article-title":"Safety and pharmacokinetics of the antiorthopoxvirus compound ST-246 following repeat oral dosing in healthy adult subjects","volume":"54","author":"R Jordan","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"9","key":"ppat.1013140.ref006","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1128\/AAC.00904-12","article-title":"Safety and pharmacokinetics of the anti-orthopoxvirus compound ST-246 following a single daily oral dose for 14 days in human volunteers","volume":"56","author":"J Chinsangaram","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ppat.1013140.ref007","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1056\/NEJMoa1705688","article-title":"Oral tecovirimat for the treatment of smallpox","volume":"379","author":"DW Grosenbach","year":"2018","journal-title":"N Engl J 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Identification of a conserved acceptor motif and biological relevance","volume":"272","author":"DW Grosenbach","year":"1997","journal-title":"J Biol Chem"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1013140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T16:03:07Z","timestamp":1747411387000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1013140"}},"subtitle":[],"editor":[{"given":"Matthew J.","family":"Evans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":14,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1013140","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}