{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:48:18Z","timestamp":1792043298932,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013156","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_192567"],"award-info":[{"award-number":["310030_192567"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["10.001.588"],"award-info":[{"award-number":["10.001.588"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["51NF40_180575"],"award-info":[{"award-number":["51NF40_180575"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHU 3606\/1-1"],"award-info":[{"award-number":["SCHU 3606\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Motile bacteria use chemotaxis to navigate complex environments like the mammalian gut. These bacteria sense a range of chemoeffector molecules, which can either be of nutritional value or provide a cue for the niche best suited for their survival and growth. One such cue molecule is the intra- and interspecies quorum sensing signaling molecule, autoinducer-2 (AI-2). Apart from controlling collective behavior of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , chemotaxis towards AI-2 contributes to its ability to colonize the murine gut. However, the impact of AI-2-dependent niche occupation by\n                    <jats:italic>E. coli<\/jats:italic>\n                    on interspecies interactions\n                    <jats:italic>in vivo<\/jats:italic>\n                    is not fully understood. Using the C57BL\/6J mouse infection model, we show that chemotaxis towards AI-2 contributes to nutrient competition and thereby affects colonization resistance conferred by\n                    <jats:italic>E. coli<\/jats:italic>\n                    against the enteric pathogen\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    serovar Typhimurium (\n                    <jats:italic>S.<\/jats:italic>\n                    Tm). Like\n                    <jats:italic>E. coli<\/jats:italic>\n                    ,\n                    <jats:italic>S.<\/jats:italic>\n                    Tm also relies on chemotaxis, albeit not towards AI-2, to compete against residing\n                    <jats:italic>E. coli<\/jats:italic>\n                    in a gut inflammation-dependent manner. Finally, utilizing a barcoded\n                    <jats:italic>S<\/jats:italic>\n                    . Tm mutant pool, we investigated the impact of AI-2 signaling in\n                    <jats:italic>E. coli<\/jats:italic>\n                    on carbohydrate utilization and central metabolism of\n                    <jats:italic>S.<\/jats:italic>\n                    Tm. Interestingly, AI-2-dependent niche colonization by\n                    <jats:italic>E. coli<\/jats:italic>\n                    was highly specific, impacting only a limited number of\n                    <jats:italic>S.<\/jats:italic>\n                    Tm mutants at distinct time points during infection. Notably, it significantly altered the fitness of mutants deficient in mannose utilization (\u0394\n                    <jats:italic>manA<\/jats:italic>\n                    , early stage infection) and, to a lesser extent, fumarate respiration (\u0394\n                    <jats:italic>dcuABC,<\/jats:italic>\n                    late stage infection). The role of quorum sensing and chemotaxis in metabolic competition among bacteria remains largely unexplored. Here, we provide initial evidence that AI-2-dependent nutrient competition occurs between\n                    <jats:italic>S.<\/jats:italic>\n                    Tm and\n                    <jats:italic>E. coli<\/jats:italic>\n                    at specific time points during infection. These findings represent a crucial step toward understanding how bacteria navigate the gastrointestinal tract and engage in targeted nutrient competition within this complex three-dimensional environment.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013156","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T16:01:53Z","timestamp":1746201713000},"page":"e1013156","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Interplay between chemotaxis, quorum sensing, and metabolism regulates Escherichia coli-Salmonella Typhimurium interactions in vivo"],"prefix":"10.1371","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6977-9591","authenticated-orcid":true,"given":"Leanid","family":"Laganenka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7921-1470","authenticated-orcid":true,"given":"Christopher","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Sichert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kalita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manja","family":"Barthel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bidong D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"N\u00e4f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lobriglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Dietrich","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ppat.1013156.ref001","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1146\/annurev-micro-092611-150120","article-title":"Bacterial chemotaxis: the early years of molecular studies","volume":"66","author":"GL Hazelbauer","year":"2012","journal-title":"Annu Rev 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