{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:12:42Z","timestamp":1791267162128,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013164","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000}}],"reference-count":121,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007780","name":"Indian Institute of Science","doi-asserted-by":"publisher","award":["MoE-STARS\/STAR-2\/2023-0460"],"award-info":[{"award-number":["MoE-STARS\/STAR-2\/2023-0460"]}],"id":[{"id":"10.13039\/100007780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SPR\/2021\/000175-G"],"award-info":[{"award-number":["SPR\/2021\/000175-G"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR47905\/MED\/29\/1643\/2023"],"award-info":[{"award-number":["BT\/PR47905\/MED\/29\/1643\/2023"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Revati and Satya Nadham Atluri Chair Professorship"},{"name":"CryptoRelief Fund","award":["ODAA\/INT\/20-21"],"award-info":[{"award-number":["ODAA\/INT\/20-21"]}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Institute of Eminence, Ministry of Education, India","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"Department of Biotechnology, India Science, Technology & Innovation Portal","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"University Grant Commission"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Viruses modulate various aspects of host physiology, including carbon metabolism, redox balance, and mitochondrial bioenergetics to acquire the building blocks for replication and regulation of the immune response. Understanding how SARS-CoV-2 alters the host metabolism may lead to treatments for COVID-19. We report that a ubiquitous gaseous molecule, hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), regulates redox, metabolism, and mitochondrial bioenergetics to control SARS-CoV-2. Virus replication is associated with down-regulation of the H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing enzymes cystathionine-\u03b2-synthase (CBS), cystathionine-\u03b3-lyase (CTH), and 3-mercaptopyruvate sulfurtransferase (3-MST) in multiple cell lines and nasopharyngeal swabs of symptomatic COVID-19 patients. Consequently, SARS-CoV-2-infected cells showed diminished endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S levels and a protein modification (S-sulfhydration) caused by H\n                    <jats:sub>2<\/jats:sub>\n                    S. Genetic silencing or chemical inhibition of CTH resulted in SARS-CoV-2 proliferation. Chemical supplementation of H\n                    <jats:sub>2<\/jats:sub>\n                    S using a slow-releasing H\n                    <jats:sub>2<\/jats:sub>\n                    S donor, GYY4137, diminished virus replication. Using a redox biosensor, metabolomics, transcriptomics, and XF-flux analyzer, we showed that GYY4137 blocked SARS-CoV-2 replication by inducing the Nrf2\/Keap1 pathway, restoring redox balance and carbon metabolites and potentiating mitochondrial oxidative phosphorylation. Treatment of SARS-CoV-2-infected mice or hamsters with GYY4137 suppressed viral replication and ameliorated lung pathology. GYY4137 treatment reduced the expression of inflammatory cytokines and re-established the expression of Nrf2-dependent antioxidant genes in the lungs of SARS-CoV-2-infected mice. Notably, non-invasive measurement of respiratory functions using unrestrained whole-body plethysmography (uWBP) of SARS-CoV-2-infected mice showed improved pulmonary function variables, including pulmonary obstruction (Penh), end-expiratory pause (EEP), and relaxation time (RT) upon GYY4137 treatment. Together, our findings significantly extend our understanding of H\n                    <jats:sub>2<\/jats:sub>\n                    S-mediated regulation of viral infections and open new avenues for investigating the pathogenic mechanisms and therapeutic opportunities for coronavirus-associated disorders.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013164","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:30:38Z","timestamp":1747661438000},"page":"e1013164","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection"],"prefix":"10.1371","volume":"21","author":[{"given":"Ragini","family":"Agrawal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virender 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