{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:42:08Z","timestamp":1789580528466,"version":"build-2803163510"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01DE026600"],"award-info":[{"award-number":["R01DE026600"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI172713"],"award-info":[{"award-number":["U19AI172713"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI177254"],"award-info":[{"award-number":["R01AI177254"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p><jats:italic>Candida albicans<\/jats:italic> is a normal constituent of the human microbiota and a ubiquitous human threat. This fungus causes diseases ranging from superficial cutaneous and mucosal candidiasis to life-threatening disseminated candidiasis. <jats:italic>C. albicans<\/jats:italic> hyphae secrete candidalysin, a cytolytic peptide toxin that damages host cells and activates immune responses. Candidalysin plays a key role in both pathogenicity and commensalism. In this Pearl, we review the host targets of candidalysin and how they modulate the interaction of <jats:italic>C. albicans<\/jats:italic> with the host.<\/jats:p>","DOI":"10.1371\/journal.ppat.1013284","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T17:43:25Z","timestamp":1750700605000},"page":"e1013284","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Host targets of candidalysin"],"prefix":"10.1371","volume":"21","author":[{"given":"Jianfeng","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-3700","authenticated-orcid":true,"given":"Scott 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Kasper","year":"2018","journal-title":"Nat Commun"},{"key":"ppat.1013284.ref007","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75490","article-title":"The Candida albicans virulence factor candidalysin polymerizes in solution to form membrane pores and damage epithelial cells","volume":"11","author":"CM Russell","year":"2022","journal-title":"Elife"},{"issue":"3","key":"ppat.1013284.ref008","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41564-024-01606-z","article-title":"Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences","volume":"9","author":"R M\u00fcller","year":"2024","journal-title":"Nat Microbiol"},{"issue":"2","key":"ppat.1013284.ref009","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrmicro.2015.3","article-title":"Pore-forming toxins: ancient, but never really out of fashion","volume":"14","author":"M Dal Peraro","year":"2016","journal-title":"Nat Rev 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