{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T19:51:18Z","timestamp":1780429878704,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013382","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000}}],"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI105265"],"award-info":[{"award-number":["R01AI105265"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD107798"],"award-info":[{"award-number":["R01HD107798"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI110613"],"award-info":[{"award-number":["R01AI110613"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI142382"],"award-info":[{"award-number":["R21AI142382"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002570","name":"American Association of Immunologists","doi-asserted-by":"publisher","award":["Intersect Fellowship for Computational Scientist and Immunologist"],"award-info":[{"award-number":["Intersect Fellowship for Computational Scientist and Immunologist"]}],"id":[{"id":"10.13039\/100002570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1173027"],"award-info":[{"award-number":["1173027"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Cytomegalovirus (CMV) leads to a unique phenomenon known as \u2018memory inflation,\u2019 where antigen-specific memory CD8\u2009+\u2009T cells continue to accumulate in the peripheral tissues during the latent stage of infection. However, it is still not clear how the inflating pool of memory CD8\u2009+\u2009T cells is generated and maintained. In this study, we used murine cytomegalovirus (MCMV) as a model of persistent infection and fate-mapping mice to determine the dynamics of CD8\u2009+\u2009T cell recruitment into the memory pool. We found that neonatal exposure to CMV leads to an expansion of newly produced CD8\u2009+\u2009T cells called recent thymic emigrants, or RTEs, which are maintained in the long-lived memory compartment. In contrast, CD8\u2009+\u2009T cells produced after the acute phase of infection contribute minimally to memory inflation. We also observed notable phenotypic differences between the RTEs and mature CD8\u2009+\u2009T cells that were recruited into the memory inflation response. Whereas the RTEs present at the time of infection gave rise to more effector memory cells, the mature CD8\u2009+\u2009T cells were biased towards becoming central memory cells. Importantly, the preferential recruitment of RTEs into the effector memory pool also occurs during adult exposure to CMV. Collectively, these data demonstrate that persistent infection expands the RTE population, and timing of infection dictates whether neonatal or adult RTEs are \u2018locked in\u2019 to the memory pool.<\/jats:p>","DOI":"10.1371\/journal.ppat.1013382","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T17:58:11Z","timestamp":1753725491000},"page":"e1013382","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recent thymic emigrants preferentially undergo memory inflation after persistent infection"],"prefix":"10.1371","volume":"21","author":[{"given":"Zachary 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