{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:06:44Z","timestamp":1789153604605,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013528","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000}}],"reference-count":112,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1132975, 1154265"],"award-info":[{"award-number":["1132975, 1154265"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1141278, 1125656, 1181932"],"award-info":[{"award-number":["1141278, 1125656, 1181932"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023410","name":"Snow Medical","doi-asserted-by":"publisher","award":["2022\/SF167"],"award-info":[{"award-number":["2022\/SF167"]}],"id":[{"id":"10.13039\/501100023410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Malaria, caused by\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, is a significant global health issue. CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are important for immunity against\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infections, but the specific roles of many immune-related effector molecules in T cells remain poorly defined. Here, we investigated the function of NK cell granule protein 7 (NKG7) in T cells during malaria, focusing on its role in CD4\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    blood-stage responses. In a non-lethal malaria model, NKG7 regulated the development of pro-inflammatory T helper 1 (Th1), IL-10-producing type 1 regulatory (Tr1), and T follicular helper cell responses. In a model of cerebral malaria, NKG7 had a cell-intrinsic role in regulating perforin and granzyme B expression, as well as Tr1 cell development. Human investigations involving peripheral blood mononuclear cells from volunteers participating in controlled human\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    malaria infection studies, as well as endemic country patients with\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    and\n                    <jats:italic>P. vivax<\/jats:italic>\n                    malaria, corroborated these findings. High NKG7 expression in T cells from\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    -infected humans was observed, as well as differences in NKG7 expression based on the infecting\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species. NKG7 expression was associated with both cytotoxic and non-cytotoxic T cells, indicating varied functions following infection. These results advance our understanding about NKG7\u2019s role in T cell-mediated malaria immunity and suggest potential for targeting NKG7 to improve outcomes following\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013528","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:56:17Z","timestamp":1788890177000},"page":"e1013528","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the functions of NKG7 in CD4+ and CD8+ T cells during malaria"],"prefix":"10.1371","volume":"22","author":[{"given":"Teija C-M.","family":"Frame","sequence":"first","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]},{"name":"University of Queensland","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"de Labastida Rivera","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas L.","family":"Dooley","sequence":"additional","affiliation":[{"name":"Burnet Institute","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Engel","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrui","family":"Na","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Wang","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzia","family":"Bukali","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna S.","family":"Ng","sequence":"additional","affiliation":[{"name":"University of Bonn","place":["Bonn, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick T.","family":"Bunn","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynette","family":"Beattie","sequence":"additional","affiliation":[{"name":"The University of Melbourne at the Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"],"department":["Department of Infectious Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-6450","authenticated-orcid":true,"given":"Gunter","family":"Hartel","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"William","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University","place":["Darwin, Northern Territory, Australia"]},{"name":"Infectious Diseases Society Kota Kinabalu Sabah-Menzies School of Health Research Program","place":["Kota Kinabalu, Sabah, Malaysia"]},{"name":"Subang Jaya Medical Centre","place":["Selangor, Malaysia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Grigg","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University","place":["Darwin, Northern Territory, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Anstey","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University","place":["Darwin, Northern Territory, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"The University of Melbourne at the Peter Doherty Institute for Infection and Immunity","place":["Melbourne, Australia"],"department":["Department of Infectious Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget E.","family":"Barber","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]},{"name":"Menzies School of Health Research, Charles Darwin University","place":["Darwin, Northern Territory, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Burnet Institute","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-4804","authenticated-orcid":true,"given":"Christian R.","family":"Engwerda","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute","place":["Brisbane, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"ppat.1013528.ref001","volume-title":"World malaria report 2024","author":"WHO","year":"2024"},{"key":"ppat.1013528.ref002","author":"GWH Organization","year":"2022","journal-title":"World malaria report 2022"},{"issue":"9","key":"ppat.1013528.ref003","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41577-024-01041-5","article-title":"The 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