{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:30:17Z","timestamp":1791945017070,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013691","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"crossref","award":["RGPIN-2025-07045"],"award-info":[{"award-number":["RGPIN-2025-07045"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003151","name":"Fonds de recherche du Qu\u00c3\u00a9bec \u00e2\u20ac\u201c Nature et technologies","doi-asserted-by":"publisher","award":["CRIPA Research Centre"],"award-info":[{"award-number":["CRIPA Research Centre"]}],"id":[{"id":"10.13039\/501100003151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Fimbrial adhesins are surface-associated bacterial proteins that contribute to colonization, tissue tropism, and biofilm formation. Genomic analysis of the avian pathogenic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (APEC) strain QT598 identified a plasmid-localized fimbrial operon, termed\n                    <jats:italic>plf<\/jats:italic>\n                    which encodes P-like (PL) fimbriae. Herein, we investigated the role of P-like (PL) fimbriae, encoded on the ColV plasmid of APEC strain QT598, in a natural host turkey respiratory infection model. We determined that deletion of the\n                    <jats:italic>plf<\/jats:italic>\n                    genes reduced colonization in the lungs of turkeys. The PlfG class II fimbrial adhesin from APEC strain QT598 demonstrated species- and tissue-specific adherence, as adherence to turkey lung sections was more pronounced than adherence to chicken lung sections.\n                    <jats:italic>In vivo<\/jats:italic>\n                    , expression of\n                    <jats:italic>plf<\/jats:italic>\n                    was also found to be upregulated in the lungs of turkeys during infection, as determined by qRT-PCR. Glycan array analysis showed that the PlfG class II adhesin recognizes Lewis b, Lewis y, and H antigens as potential receptors that are present on human red blood cells and on the surface of turkey respiratory tissues, implicating specific \u03b1-1,2-linked glycans as receptors. Structural modelling of Plf adhesin revealed conserved \u03b2-sandwich folds with distinct binding pockets that predict receptor specificity differences between Plf adhesin variants and other fimbrial adhesins such as PapG II and the PlfG class I adhesin from UMEA 3703\u20131. These findings highlight the role of PL fimbriae in APEC virulence and suggest a potential zoonotic and foodborne risk from poultry to humans, demonstrating the common recognition of glycans present on both turkey and mammalian host cells and tissues.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013691","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T17:44:01Z","timestamp":1775497441000},"page":"e1013691","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Host range and zoonotic potential linked to P-like fimbrial (PLF) adhesin specificity in avian pathogenic Escherichia coli"],"prefix":"10.1371","volume":"22","author":[{"given":"Fariba","family":"Akrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Jamali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Houle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Armoa","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Calmettes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-3936","authenticated-orcid":true,"given":"Charles M.","family":"Dozois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"ppat.1013691.ref001","doi-asserted-by":"crossref","first-page":"106843","DOI":"10.1016\/j.micpath.2024.106843","article-title":"Prevalence of specific serogroups, antibiotic resistance and virulence factors of avian pathogenic Escherichia coli (APEC) isolated from clinical cases: A systematic review and meta-analysis","volume":"194","author":"H Jamali","year":"2024","journal-title":"Microb Pathog"},{"issue":"5","key":"ppat.1013691.ref002","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1080\/03079457.2021.1915960","article-title":"The avian pathogenic Escherichia coli (APEC) pathotype is comprised of multiple distinct, independent genotypes","volume":"50","author":"JW Mehat","year":"2021","journal-title":"Avian 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