{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:57:47Z","timestamp":1792569467862,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013693","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000}}],"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2011\/03\/B\/NZ4\/02152"],"award-info":[{"award-number":["2011\/03\/B\/NZ4\/02152"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2011\/03\/N\/NZ8\/02113"],"award-info":[{"award-number":["2011\/03\/N\/NZ8\/02113"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2011\/03\/N\/NZ8\/02115"],"award-info":[{"award-number":["2011\/03\/N\/NZ8\/02115"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007088","name":"Uniwersytet Jagiello\u0144ski w Krakowie","doi-asserted-by":"publisher","award":["DS\/WB\/INOS\/757"],"award-info":[{"award-number":["DS\/WB\/INOS\/757"]}],"id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007088","name":"Uniwersytet Jagiello\u0144ski w Krakowie","doi-asserted-by":"publisher","award":["N18\/DBS\/000021"],"award-info":[{"award-number":["N18\/DBS\/000021"]}],"id":[{"id":"10.13039\/501100007088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI1721A"],"award-info":[{"award-number":["01KI1721A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01KI2004A"],"award-info":[{"award-number":["01KI2004A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Bank voles (\n                    <jats:italic>Myodes glareolus<\/jats:italic>\n                    syn.\n                    <jats:italic>Clethrionomys glareolus<\/jats:italic>\n                    ) are frequently used as an animal model in ecological and biomedical studies and are an important reservoir of viral and bacterial zoonotic pathogens, e.g., Puumala hantavirus (PUUV). Here we describe an accidental PUUV outbreak in a large bank vole laboratory colony caused by an accidental introduction of infected wild-trapped bank voles, and the successful eradication of the virus. The eradication plan was based on results of previous studies showing that maternal antibodies (MatAb) protect the young from infection for up to 40 days after weaning, four weeks longer than the estimated duration of PUUV infectivity in the environment. After ensuring that most animals were infected, 620 pairs were mated on the same day. Only females that showed PUUV-specific antibodies and produced offspring within 26 days after mating were retained. All individuals of the parental generation were euthanized before the last weaning. The weaned offspring were moved to individually ventilated cages (IVC) and repeatedly tested for the presence of PUUV-specific antibodies and RNA. A few infected or suspect animals were euthanized. The animals were then mated (in IVC) and, after producing grand-offspring generation, euthanized and tested for PUUV RNA in the lungs. No PUUV RNA was detected, and no animals showed PUUV-specific antibodies in subsequent generations. The successful clearance confirmed the protective efficiency of PUUV-specific MatAb. The procedure for PUUV clearance in the bank vole colony may represent a blueprint for similar approaches in valuable colonies of other rodents infected by similar pathogens.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013693","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:41:53Z","timestamp":1780076513000},"page":"e1013693","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony"],"prefix":"10.1371","volume":"22","author":[{"given":"Stephan","family":"Drewes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wyszkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Jaromin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Hajduk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Onik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Konczal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystyna","family":"Lach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Bober-Sowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Baliga-Klimczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edyta T.","family":"Sadowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer G.","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0077-4957","authenticated-orcid":true,"given":"Pawe\u0142","family":"Koteja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"issue":"2","key":"ppat.1013693.ref001","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1084\/jem.64.2.183","article-title":"The epidemiology of lymphocytic choriomeningitis in white mice","volume":"64","author":"E Traub","year":"1936","journal-title":"J Exp Med"},{"issue":"3","key":"ppat.1013693.ref002","first-page":"205","article-title":"Persistence of Sendai virus in a mouse breeder colony and possibility to re-establish the virus free 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vole","volume":"81","author":"ET Sadowska","year":"2008","journal-title":"Physiol Biochem Zool"},{"issue":"1806","key":"ppat.1013693.ref006","first-page":"20150025","article-title":"Evolution of basal metabolic rate in bank voles from a multidirectional selection experiment","volume":"282","author":"ET Sadowska","year":"2015","journal-title":"Proc Biol Sci"},{"key":"ppat.1013693.ref007","article-title":"Bank vole biology: Recent advances in the population biology of a model species","volume":"48","author":"G Bujalska","year":"2000","journal-title":"Pol J Ecol"},{"issue":"3","key":"ppat.1013693.ref008","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00442-020-04704-x","article-title":"The metabolic performance predicts home range size of bank voles: A support for the behavioral-bioenergetics theory","volume":"193","author":"Z 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glareolus)","volume":"14","author":"J Hardestam","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"ppat.1013693.ref025","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1099\/vir.0.81643-0","article-title":"Prolonged survival of Puumala hantavirus outside the host: Evidence for indirect transmission via the environment","volume":"87","author":"ER Kallio","year":"2006","journal-title":"J Gen Virol"},{"issue":"1","key":"ppat.1013693.ref026","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/jvi.55.1.34-38.1985","article-title":"Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus)","volume":"55","author":"R Yanagihara","year":"1985","journal-title":"J Virol"},{"key":"ppat.1013693.ref027","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-7091-9091-3_7","article-title":"Pathogenesis of hemorrhagic fever with renal syndrome virus infection and mode of horizontal transmission of hantavirus in bank voles","author":"IN Gavrilovskaya","year":"1990","journal-title":"Hemorrhagic Fever with Renal Syndrome, Tick- and Mosquito-Borne Viruses. Springer Vienna"},{"issue":"1602","key":"ppat.1013693.ref028","first-page":"2771","article-title":"Maternal antibodies postpone hantavirus infection and enhance individual breeding success","volume":"273","author":"ER Kallio","year":"2006","journal-title":"Proc Biol Sci"},{"issue":"19","key":"ppat.1013693.ref029","doi-asserted-by":"crossref","first-page":"10578","DOI":"10.1073\/pnas.180197197","article-title":"Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus)","volume":"97","author":"J Botten","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ppat.1013693.ref030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4161\/hv.7.6.15197","article-title":"Human pathogenic hantaviruses and prevention of infection","volume":"7","author":"DH Kr\u00fcger","year":"2011","journal-title":"Hum 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