{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:46:08Z","timestamp":1777873568191,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013852","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022991","name":"HIV\/AIDS and STBBI Research Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Interleukin-17-producing T helper (Th17) CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells are highly susceptible to HIV infection and are depleted early in people living with HIV. Here, we investigated whether systemic Th17 cell levels prior to HIV infection are associated with subsequent HIV disease progression. We analyzed archived cryopreserved peripheral blood mononuclear cells (PBMCs) collected within one year prior to HIV acquisition from participants enrolled in a South African cohort (HIV Vaccine Trials Network [HVTN] 503; n\u2009=\u200935) and an East African cohort (Partners Pre-exposure Prophylaxis\/Couples\u2019 Observational Study [PP\/COS]; n\u2009=\u200932). Th17 cell frequencies were quantified by flow cytometry. In HVTN 503, higher pre-HIV IL-17\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell frequencies were inversely correlated with CD4\/CD8 ratio measured both within 180 days (Spearman rank r\n                    <jats:sub>s<\/jats:sub>\n                    \u2009=\u2009-0.42,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012) and \u2265180 days (r\n                    <jats:sub>s<\/jats:sub>\n                    \u2009=\u2009-0.55,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) after HIV infection, and were associated with faster CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells decline (adjusted hazard ratio [aHR] = 3.5, 95% CI: 1.2 \u2013 9.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.020). In contrast, no significant association with CD4 decline was observed in the PP\/COS cohort (HR\u2009=\u20091.2, 95% CI: 0.4 \u2013 3.4,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.795). Sex-stratified analyses in HVTN 503 indicated a more pronounced association between pre-HIV IL-17\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells and faster CD4 decline in males than females. In analyses combining all cohorts, higher pre-HIV IL-17\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell frequencies remained associated with faster CD4 decline, particularly among younger participants (HR\u2009=\u20093.5; 95% CI: 1.35 \u2013 9.22,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010). Pre-HIV IL-17\n                    <jats:sup>+<\/jats:sup>\n                    CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell frequencies were not associated with peak or set-point viral load in either cohort. Together, these findings suggest that pre-HIV Th17 cells abundance may influence subsequent HIV disease progression independently of early viral replication.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1013852","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:56:31Z","timestamp":1777053391000},"page":"e1013852","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Human Immunodeficiency Virus (HIV) infection Th17 CD4+ T cells as predictors of early HIV disease progression"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-266X","authenticated-orcid":true,"given":"Tosin E.","family":"Omole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huong Mai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Marcinow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naima","family":"Jahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Severini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivashnee","family":"Naicker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie","family":"Celum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Mugo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Mujugira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kublin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Corey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Sivro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jairam","family":"Lingappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyle R.","family":"McKinnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"425","key":"ppat.1013852.ref001","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam6354","article-title":"Integrin \u03b14\u03b27 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes","volume":"10","author":"A Sivro","year":"2018","journal-title":"Sci Transl Med"},{"issue":"136","key":"ppat.1013852.ref002","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003941","article-title":"SIV replication in the infected rhesus macaque is limited by the size of the preexisting TH17 cell compartment","volume":"4","author":"DJ Hartigan-O\u2019Connor","year":"2012","journal-title":"Sci Transl 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