{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:03:35Z","timestamp":1787022215160,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.ppat.1013902","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["101019724\u2014EVADER"],"award-info":[{"award-number":["101019724\u2014EVADER"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-118602RB-I00\u2014ZooVir"],"award-info":[{"award-number":["PID2020-118602RB-I00\u2014ZooVir"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023561","name":"Ministerio de Universidades","doi-asserted-by":"publisher","award":["FPU21\/03807"],"award-info":[{"award-number":["FPU21\/03807"]}],"id":[{"id":"10.13039\/501100023561","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 140-2021"],"award-info":[{"award-number":["ALTF 140-2021"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["101104880"],"award-info":[{"award-number":["101104880"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>Sialic acids (SAs) are abundantly expressed on vertebrate cell surfaces and are widely recognized as key viral attachment factors, particularly for influenza viruses. However, their role remains understudied in other orthomyxoviruses, such as thogoto and quaranja viruses, which are tick-borne viruses sporadically infecting humans. Enzymatic removal of SAs increased the infectivity of Thogoto and Dhori viruses, as well as pseudotypes carrying the glycoproteins of Oz, Sinu, and Wellfleet Bay viruses. A similar effect on pseudotype infectivity was observed following the binding of specific lectins to SAs. These findings indicate that, in contrast to influenza viruses, SAs act as a barrier to the entry of these orthomyxoviruses. Experimental evolution of the Sinu and Wellfleet Bay virus glycoproteins revealed point mutations that partially overcame this barrier. Given the abundance of sialic acids in mucosal tissues, we speculate that SAs may contribute to the inability of thogoto and quaranjaviruses to transmit directly between vertebrate hosts. Our results also underscore the importance of monitoring the circulation of these viruses for potential changes in their transmission routes.<\/jats:p>","DOI":"10.1371\/journal.ppat.1013902","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:45:03Z","timestamp":1783532703000},"page":"e1013902","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sialic acids are a barrier to the entry of non-influenza orthomyxoviruses"],"prefix":"10.1371","volume":"22","author":[{"given":"Gabriel","family":"Dupr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5344-3848","authenticated-orcid":true,"given":"Jorge","family":"Moreno-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Bendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Kochs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Dufloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-545X","authenticated-orcid":true,"given":"Rafael","family":"Sanju\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"issue":"1","key":"ppat.1013902.ref001","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-virology-122019-070025","article-title":"Initial step of virus entry: virion binding to cell-surface glycans","volume":"7","author":"M Koehler","year":"2020","journal-title":"Annu Rev Virol"},{"key":"ppat.1013902.ref002","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/978-4-431-54841-6_152","article-title":"Viral interactions with glycans.","author":"T Suenaga","year":"2015","journal-title":"Glycoscience: biology and medicine"},{"key":"ppat.1013902.ref003","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/9781118017586.ch3","article-title":"The role of carbohydrates in viral infections.","author":"GM. 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