{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:11:47Z","timestamp":1773879107890,"version":"3.50.1"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFF0710503"],"award-info":[{"award-number":["2022YFF0710503"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82522053"],"award-info":[{"award-number":["82522053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFF0724603"],"award-info":[{"award-number":["2023YFF0724603"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005198","name":"Chinese Foundation for Hepatitis Prevention and Control","doi-asserted-by":"publisher","award":["CLH2023-F-HEV-18"],"award-info":[{"award-number":["CLH2023-F-HEV-18"]}],"id":[{"id":"10.13039\/501100005198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007870","name":"Department of Obstetrics and Gynecology, University of Wisconsin-Madison","doi-asserted-by":"publisher","award":["BYSYSZKF2023006"],"award-info":[{"award-number":["BYSYSZKF2023006"]}],"id":[{"id":"10.13039\/100007870","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Hepatitis E virus genotype 1 (HEV-1) has long been considered human-specific, with no known natural animal hosts. Here, we demonstrate that three wild rodent species\u2014\n                    <jats:italic>Apodemus peninsulae<\/jats:italic>\n                    ,\n                    <jats:italic>Clethrionomys rufocanus<\/jats:italic>\n                    , and\n                    <jats:italic>Lasiopodomys brandtii<\/jats:italic>\n                    \u2014are susceptible to HEV-1 infection. Among them,\n                    <jats:italic>A. peninsulae<\/jats:italic>\n                    infected with HEV-1 exhibited the highest susceptibility, characterized by robust fecal viral shedding, systemic viral replication, seroconversion, and mild liver pathology mimicking human acute HEV-1 infection. Intrahepatic transcriptomic analysis of infected animals revealed activation of inflammatory pathways, including upregulation of\n                    <jats:italic>IL-1\u03b2<\/jats:italic>\n                    and\n                    <jats:italic>IL-18<\/jats:italic>\n                    . Re-inoculation experiments confirmed infection-induced protective immunity, and ribavirin treatment effectively suppressed viral replication. HEV-1 infection can be established by oral gavage inoculation, close contact and vertical transmission. These results provide solid evidence that wild rodents can serve as potential hosts for HEV-1, highlighting the potential role of wild rodents in HEV-1 ecology and cross-species transmission.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014050","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:38:32Z","timestamp":1773855512000},"page":"e1014050","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experimental hepatitis E virus genotype 1 infection in three types of wild 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