{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:42:32Z","timestamp":1789051352929,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014053","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000}}],"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin University's Outstanding Young Talent Development Program","award":["419250320048"],"award-info":[{"award-number":["419250320048"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Mastitis, a major dairy industry challenge, is often caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ). Previous research linked gut microbiota disruption\u2014induced by vancomycin in mice\u2014to reduced microbial glutamine and increased mastitis susceptibility. This study hypothesizes that oral glutamine may regulate macrophage function and mitigate\n                    <jats:italic>S. aureus<\/jats:italic>\n                    mastitis. Our results showed that glutamine attenuated\n                    <jats:italic>S. aureus<\/jats:italic>\n                    -induced mastitis, protected the blood-milk barrier function, increased M2-type macrophages in the mammary gland, and increased the concentration of its metabolite \u03b1-Ketoglutaric acid (\u03b1KG) in both serum and mammary gland. In addition, the addition of \u03b1KG in mice significantly increased the transformation of M2-type macrophages and attenuated\n                    <jats:italic>S. aureus<\/jats:italic>\n                    -induced mastitis. Further studies revealed that \u03b1KG could initiate autophagy via oxidative phosphorylation, which in turn regulated the expression of Suppressor of cytokine signaling (SOCS3), a negative feedback inhibitor of the JAK\/STAT signalling pathway. In vitro experiments verified that \u03b1KG enhances autophagy in macrophages, activates the JAK-STAT pathway, thereby promoting M2 polarization and alleviating\n                    <jats:italic>S. aureus<\/jats:italic>\n                    mastitis. This study revealed the key role of glutamine and its metabolite \u03b1KG in the mammary gland\u2019s resistance to pathogenic infections, and reveal the mechanism by which they regulate macrophage polarization, providing theoretical guidance for solving the prevention and treatment problems of mastitis. This highlights a potential dietary intervention for mastitis management in dairy cows, bridging gut health and infection resistance.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014053","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:38:55Z","timestamp":1773250735000},"page":"e1014053","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glutamine alleviates Staphylococcus aureus-induced mastitis by modulating macrophage 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