{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:50:59Z","timestamp":1784739059747,"version":"3.55.0"},"reference-count":153,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gates foundation","award":["INV-033558"],"award-info":[{"award-number":["INV-033558"]}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF0010\\1085"],"award-info":[{"award-number":["SBF0010\\1085"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["207511\/Z\/17\/Z and 306550\/Z\/23\/Z"],"award-info":[{"award-number":["207511\/Z\/17\/Z and 306550\/Z\/23\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["201433\/A\/16\/A, 210662\/Z\/18\/Z and 317454\/Z\/24\/Z)."],"award-info":[{"award-number":["201433\/A\/16\/A, 210662\/Z\/18\/Z and 317454\/Z\/24\/Z)."]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["20230576"],"award-info":[{"award-number":["20230576"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The number 17 is considered unlucky by some Italians as its Roman numerals \u2013 XVII \u2013 can be rearranged as\n                    <jats:italic>Vixi<\/jats:italic>\n                    , a Latin expression that can be interpreted as \u201cmy life is over\u201d. In other contexts, the number 17 is associated with wisdom and success. This paradox holds true when it comes to the role of interleukin 17 (IL-17) in tuberculosis (TB). On one hand, immune correlates of protection studies have consistently identified IL-17 responses as key players in natural and vaccine induced protection against infection and disease. On the other, IL-17 has been proposed as a main driver of the immunopathology that underlies TB morbidity and mortality. Thus, while some researchers seek to develop novel TB vaccine approaches that promote IL-17 responses, others hunt for host-directed therapeutic approaches that block its activity. In this article, we attempt to address this conundrum and synthesise the main arguments supporting a role for IL-17 in the protection and pathogenesis of this deadly human infectious disease. Ultimately, as with superstition, whether the 17th interleukin is friend or foe in human TB is likely to depend on the context.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014054","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:35:36Z","timestamp":1776792936000},"page":"e1014054","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Context-specific roles for IL-17 in tuberculosis"],"prefix":"10.1371","volume":"22","author":[{"given":"Mahlatse","family":"Maseeme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liku 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Enriquez","year":"2022","journal-title":"iScience"},{"issue":"4","key":"ppat.1014054.ref023","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni1449","article-title":"IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge","volume":"8","author":"SA Khader","year":"2007","journal-title":"Nat Immunol"},{"issue":"1","key":"ppat.1014054.ref024","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1038\/s41467-021-26934-0","article-title":"A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Gu\u00e9rin","volume":"12","author":"JS Woodworth","year":"2021","journal-title":"Nat Commun"},{"issue":"5","key":"ppat.1014054.ref025","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3390\/vaccines9050519","article-title":"Balance between protection and pathogenic response to aerosol challenge with 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cynomolgus macaques","volume":"9","author":"AS Wareham","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"ppat.1014054.ref037","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq8229","article-title":"High-dose intravenous BCG vaccination induces enhanced immune signaling in the airways","volume":"11","author":"JM Peters","year":"2025","journal-title":"Sci Adv"},{"key":"ppat.1014054.ref038","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.chom.2023.05.006","article-title":"Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques","volume":"31","author":"PA Darrah","year":"2023","journal-title":"Cell Host Microbe"},{"issue":"7788","key":"ppat.1014054.ref039","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41586-019-1817-8","article-title":"Prevention of tuberculosis in macaques after intravenous BCG immunization","volume":"577","author":"PA Darrah","year":"2020","journal-title":"Nature"},{"issue":"2","key":"ppat.1014054.ref040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41591-018-0319-9","article-title":"Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques","volume":"25","author":"K Dijkman","year":"2019","journal-title":"Nat Med"},{"issue":"3","key":"ppat.1014054.ref041","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/cmi.2008.25","article-title":"Interleukin 17-producing gamma delta T cells increased in patients with active pulmonary tuberculosis","volume":"5","author":"MY Peng","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"ppat.1014054.ref042","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.4049\/jimmunol.180.3.1962","article-title":"Distinct, specific IL-17- and IL-22-producing CD4 T cell subsets contribute to the human anti-mycobacterial immune response","volume":"180","author":"TJ Scriba","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"ppat.1014054.ref043","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/eji.201243090","article-title":"Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease","volume":"43","author":"M Perreau","year":"2013","journal-title":"Eur J Immunol"},{"issue":"4","key":"ppat.1014054.ref044","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jfma.2020.09.012","article-title":"Depression and recovery of IL-17A secretion in mitogen responses in patients with active tuberculosis-a prospective observational study","volume":"120","author":"J-Y Feng","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"ppat.1014054.ref045","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1038\/s41598-025-95386-z","article-title":"Isoniazid preventive therapy modulates Mycobacterium tuberculosis-specific T-cell responses in individuals with latent tuberculosis and type 2 diabetes","volume":"15","author":"P Ssekamatte","year":"2025","journal-title":"Sci Rep"},{"issue":"6","key":"ppat.1014054.ref046","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/s41590-021-00933-1","article-title":"Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease","volume":"22","author":"A Nathan","year":"2021","journal-title":"Nat Immunol"},{"issue":"11","key":"ppat.1014054.ref047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006687","article-title":"Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease","volume":"13","author":"TJ Scriba","year":"2017","journal-title":"PLoS Pathog"},{"issue":"8","key":"ppat.1014054.ref048","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1038\/s41590-024-01897-8","article-title":"Specific CD4+ T cell phenotypes associate with bacterial control in people who \u201cresist\u201d infection with Mycobacterium tuberculosis","volume":"25","author":"M Sun","year":"2024","journal-title":"Nat Immunol"},{"issue":"7","key":"ppat.1014054.ref049","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1164\/rccm.200909-1463OC","article-title":"Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells","volume":"181","author":"X Chen","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"ppat.1014054.ref050","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142014","article-title":"Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung","volume":"131","author":"P Ogongo","year":"2021","journal-title":"J Clin Invest"},{"issue":"1","key":"ppat.1014054.ref051","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cyto.2013.05.022","article-title":"The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain","volume":"64","author":"JG Ocejo-Vinyals","year":"2013","journal-title":"Cytokine"},{"issue":"3","key":"ppat.1014054.ref052","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/apm.12810","article-title":"The association of interferon\u2010gamma, interleukin\u20104 and interleukin\u201017 single\u2010nucleotide polymorphisms with susceptibility to tuberculosis","volume":"126","author":"F Mansouri","year":"2018","journal-title":"APMIS"},{"issue":"3","key":"ppat.1014054.ref053","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ijtb.2017.08.027","article-title":"Interleukin-17 A and F gene polymorphisms affect the risk of tuberculosis: an updated meta-analysis","volume":"65","author":"E Eskandari-Nasab","year":"2018","journal-title":"Indian J Tuberc"},{"key":"ppat.1014054.ref054","doi-asserted-by":"crossref","first-page":"154956","DOI":"10.1016\/j.cyto.2019.154956","article-title":"Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population","volume":"127","author":"W Wang","year":"2020","journal-title":"Cytokine"},{"issue":"19","key":"ppat.1014054.ref055","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92973","article-title":"Interleukin-17 limits hypoxia-inducible factor 1\u03b1 and development of hypoxic granulomas during tuberculosis","volume":"2","author":"R Domingo-Gonzalez","year":"2017","journal-title":"JCI Insight"},{"key":"ppat.1014054.ref056","doi-asserted-by":"crossref","first-page":"40666","DOI":"10.1038\/srep40666","article-title":"The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina","volume":"7","author":"A Rolandelli","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"ppat.1014054.ref057","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1164\/rccm.201311-2106PP","article-title":"Tuberculosis, pulmonary cavitation, and matrix metalloproteinases","volume":"190","author":"CWM Ong","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"ppat.1014054.ref058","article-title":"Depletion of neutrophils promotes the resolution of pulmonary inflammation and fibrosis in mice infected with Paracoccidioides brasiliensis","volume":"11","author":"JD Puerta-Arias","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"ppat.1014054.ref059","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.cmi.2022.05.022","article-title":"Inborn errors of immunity underlying a susceptibility to pyogenic infections: from innate immune system deficiency to complex phenotypes","volume":"28","author":"F Conti","year":"2022","journal-title":"Clin Microbiol Infect"},{"issue":"51","key":"ppat.1014054.ref060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1618300114","article-title":"Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency","volume":"113","author":"R L\u00e9vy","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ppat.1014054.ref061","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.20141065","article-title":"Inherited IL-17RC deficiency in patients with chronic mucocutaneous 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Bandaru","year":"2014","journal-title":"Eur J Immunol"},{"issue":"12","key":"ppat.1014054.ref126","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1007\/s00262-020-02687-5","article-title":"Increased Th17 activation and gut microbiota diversity are associated with pembrolizumab-triggered tuberculosis","volume":"69","author":"Y-B Zhang","year":"2020","journal-title":"Cancer Immunol Immunother"},{"issue":"8","key":"ppat.1014054.ref127","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1164\/rccm.202402-0374SO","article-title":"Pathogenesis of post-tuberculosis lung disease: defining knowledge gaps and research priorities at the second international post-tuberculosis symposium","volume":"210","author":"SC Auld","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"issue":"12","key":"ppat.1014054.ref128","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20250466","article-title":"Type I IFN drives neutrophil swarming, impeding lung T cell-macrophage interactions and 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Type I interferon responses contribute to immune protection against mycobacterial infection. 2025. https:\/\/doi.org\/10.7554\/eLife.106799.1","DOI":"10.7554\/eLife.106799"},{"key":"ppat.1014054.ref130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.cell.2017.12.031","article-title":"BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis","volume":"172","author":"E Kaufmann","year":"2018","journal-title":"Cell"},{"key":"ppat.1014054.ref131","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.cell.2020.09.062","article-title":"M. tuberculosis reprograms hematopoietic stem cells to limit myelopoiesis and impair trained immunity","volume":"183","author":"N Khan","year":"2020","journal-title":"Cell"},{"key":"ppat.1014054.ref132","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44519","article-title":"HIF-1\u03b1 regulates IL-1\u03b2 and IL-17 in sarcoidosis","volume":"8","author":"J 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