{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:10:12Z","timestamp":1785859812126,"version":"3.56.0"},"reference-count":110,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100025294","name":"Research Ireland","doi-asserted-by":"crossref","award":["22\/FFP-A\/10297 and 23\/ARC\/11991"],"award-info":[{"award-number":["22\/FFP-A\/10297 and 23\/ARC\/11991"]}],"id":[{"id":"10.13039\/501100025294","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Bordetella pertussis<\/jats:italic>\n                    causes whooping cough (pertussis), a respiratory infectious disease that is resurgent despite high vaccine coverage. Research on the mechanisms of immunity to\n                    <jats:italic>B. pertussis<\/jats:italic>\n                    have demonstrated protective roles for innate immune cells, antibodies and T cells in immunity induced by natural infection. Studies in animal models have demonstrated that IL-17-secreting respiratory tissue-resident memory CD4\n                    <jats:sup>+<\/jats:sup>\n                    T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells and associated recruitment of neutrophils play a critical role in clearance of bacteria from nasal mucosa. However, current acellular pertussis (aP) vaccines, while inducing potent serum antibody responses and protecting against pertussis disease, fail to induce local immune responses in the respiratory tract, thus allowing transmission of the bacteria from vaccinated individuals. Motivated by the resurgence of pertussis and the limitations of the current aP vaccines, several research groups involved in the design of more effective third generation pertussis vaccines are focusing on nasal-delivery approaches that induce respiratory T\n                    <jats:sub>RM<\/jats:sub>\n                    cells and mucosal IgA, as well as circulating antibodies.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014128","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T17:50:52Z","timestamp":1777053052000},"page":"e1014128","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mechanisms of natural and vaccine-induced immunity to Bordetella pertussis"],"prefix":"10.1371","volume":"22","author":[{"given":"Lisa","family":"Borkner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreeram","family":"Udayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Davoud","family":"Jazayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3646-8222","authenticated-orcid":true,"given":"Kingston H. G.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"issue":"9","key":"ppat.1014128.ref001","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1093\/cid\/ciw051","article-title":"Protective effect of contemporary pertussis vaccines: a systematic review and meta-analysis","volume":"62","author":"TR Fulton","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"8","key":"ppat.1014128.ref002","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3390\/vaccines13080841","article-title":"Evaluating the relationship between the introduction of the acellular pertussis vaccine and whooping cough resurgence in the United States","volume":"13","author":"J Parikh","year":"2025","journal-title":"Vaccines 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