{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:01:50Z","timestamp":1792116110030,"version":"4.4.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014158","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101027"],"award-info":[{"award-number":["82101027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370975"],"award-info":[{"award-number":["82370975"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170969"],"award-info":[{"award-number":["82170969"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2021-BS-101"],"award-info":[{"award-number":["2021-BS-101"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    , a periodontal pathogen, has been increasingly implicated in pulmonary diseases including chronic obstructive pulmonary disease (COPD). This study demonstrates that\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    adheres to and invades pulmonary epithelial cells in a dose-dependent manner, primarily mediated by its adhesin FadA. We identify cadherin-11 (CDH11), which is upregulated in COPD lungs and in pulmonary epithelial cells treated with\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    or FadAc protein, as the key host receptor for FadA. This FadA\u2013CDH11 interaction not only mediates bacterial adhesion and invasion, but also activates the MAPK13\/JUN pathway, leading to significant upregulation of pro-inflammatory cytokines including CSF3, TNF-\u03b1, CCL20, and TGF-\u03b2. Genetic knockdown of CDH11 abolishes MAPK13\/JUN activation and cytokine induction but does not affect FadA-mediated p53 suppression, indicating a separate pathway for this oncogenic event. Our findings establish the FadA\u2013CDH11\u2013MAPK13\/JUN axis as a central mechanism driving\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    -exacerbated pulmonary inflammation and tissue damage, highlighting its potential as a therapeutic target for mitigating COPD progression.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014158","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:00:11Z","timestamp":1776708011000},"page":"e1014158","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cadherin-11 serves as a novel receptor for Fusobacterium nucleatum adhesin FadA to exacerbate pulmonary inflammation"],"prefix":"10.1371","volume":"22","author":[{"given":"Kun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-8292","authenticated-orcid":true,"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"issue":"5","key":"ppat.1014158.ref001","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.chest.2024.01.003","article-title":"The 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