{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:57:30Z","timestamp":1790060250178,"version":"4.0.1"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2022YFD1800103"],"award-info":[{"award-number":["2022YFD1800103"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Flaviviruses<\/jats:italic>\n                    intricately rewire host metabolic networks to establish a replication-permissive environment; however, the role of glucose transporter-mediated uptake, particularly via glucose transporter 4 (GLUT4), remains insufficiently defined. Japanese encephalitis virus (JEV) infection induces extensive remodeling of glucose metabolism, exemplified by the coordinated upregulation of critical metabolic effectors. Pharmacological blockade of glucose metabolic pathways markedly attenuates JEV replication, whereas exogenous glucose supplementation enhances viral propagation in a concentration-dependent manner. A targeted screen of 111 metabolism-oriented compounds identified selective GLUT4 inhibitors with potent antiviral efficacy. Notably, GLUT4 expression is consistently upregulated during JEV infection across multiple cell types, albeit to varying degrees, and is similarly induced by duck Tembusu virus (DTMUV), suggesting a potentially conserved mechanism shared by these two flaviviruses. However, broader validation across additional members of the\n                    <jats:italic>Flavivirus<\/jats:italic>\n                    genus remains warranted. Mechanistically, the viral nonstructural protein 3 (NS3) engages insulin receptor substrate 1 (IRS1), thereby activating the IRS1-PI3K-Akt-mTORC1-SREBP-1c signaling axis to transcriptionally drive GLUT4 expression. Concurrently, JEV infection induces PI3K-Akt-dependent phosphorylation of AS160, promoting GLUT4 vesicular trafficking via the coordinated action of Rab8 and Rab10. Collectively, these findings delineate a previously unrecognized mechanism whereby JEV commandeers host insulin signaling to orchestrate GLUT4 biosynthesis and membrane translocation, thereby ensuring continuous metabolic substrate availability to sustain replication. This GLUT4-centric metabolic circuitry represents a mechanistically tractable target for host-directed antiviral strategies against\n                    <jats:italic>Flavivirus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014164","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:45:21Z","timestamp":1776447921000},"page":"e1014164","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["RETRACTED: Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling"],"prefix":"10.1371","volume":"22","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-fei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-chao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun 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Sano","year":"2011","journal-title":"J Biol Chem"},{"key":"ppat.1014164.ref038","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.ijbiomac.2022.03.004","article-title":"Role of polyphenols in combating Type 2 diabetes and insulin resistance","volume":"206","author":"M Shahwan","year":"2022","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"ppat.1014164.ref039","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.3390\/ijms23031264","article-title":"Metformin and insulin resistance: a review of the underlying mechanisms behind changes in GLUT4-mediated glucose transport","volume":"23","author":"R Herman","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ppat.1014164.ref040","doi-asserted-by":"crossref","first-page":"216179","DOI":"10.1016\/j.canlet.2023.216179","article-title":"Glucose transporter 4: insulin response mastermind, glycolysis catalyst and treatment direction for cancer progression","volume":"563","author":"Y-C 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Kern","year":"2015","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1014164.ref047","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12915-019-0678-9","article-title":"Viral hijacking of cellular metabolism","volume":"17","author":"SK Thaker","year":"2019","journal-title":"BMC Biol"},{"key":"ppat.1014164.ref048","doi-asserted-by":"crossref","first-page":"155917","DOI":"10.1016\/j.metabol.2024.155917","article-title":"Virus-induced diabetes mellitus: revisiting infection etiology in light of SARS-CoV-2","volume":"156","author":"SS Jeremiah","year":"2024","journal-title":"Metabolism"},{"issue":"10","key":"ppat.1014164.ref049","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/nbt.1500","article-title":"Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy","volume":"26","author":"J Munger","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"4","key":"ppat.1014164.ref050","article-title":"Zika virus infection reprograms global transcription of host cells to allow sustained infection","volume":"6","author":"SK Tiwari","year":"2017","journal-title":"Emerg Microbes Infect"},{"issue":"7","key":"ppat.1014164.ref051","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4049\/jimmunol.1901310","article-title":"AMP-activated protein kinase restricts zika virus replication in endothelial cells by potentiating innate antiviral responses and inhibiting glycolysis","volume":"204","author":"S Singh","year":"2020","journal-title":"J Immunol"},{"key":"ppat.1014164.ref052","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.3390\/cells11131982","article-title":"The possible role of glucose-6-phosphate dehydrogenase in the SARS-CoV-2 infection","volume":"11","author":"I P\u00e9rez-Torres","year":"2022","journal-title":"Cells"},{"key":"ppat.1014164.ref053","doi-asserted-by":"crossref","first-page":"103112","DOI":"10.1016\/j.redox.2024.103112","article-title":"Enteric coronavirus 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Li","year":"2020","journal-title":"NPJ Vaccines"},{"issue":"1","key":"ppat.1014164.ref060","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20060499","article-title":"Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs","volume":"400","author":"N Dif","year":"2006","journal-title":"Biochem J"},{"key":"ppat.1014164.ref061","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.antiviral.2015.03.014","article-title":"The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development","volume":"118","author":"D Luo","year":"2015","journal-title":"Antiviral Res"},{"issue":"3","key":"ppat.1014164.ref062","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1021\/id5000458","article-title":"Benzothiazole and pyrrolone flavivirus inhibitors targeting the viral helicase","volume":"1","author":"NL Sweeney","year":"2015","journal-title":"ACS Infect 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