{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:11:15Z","timestamp":1779214275138,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014207","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000}}],"reference-count":90,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CO 1469\/15-1"],"award-info":[{"award-number":["CO 1469\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009139","name":"Deutsches Zentrum f\u00c3\u00bcr Infektionsforschung","doi-asserted-by":"publisher","award":["TTU 03.818_01"],"award-info":[{"award-number":["TTU 03.818_01"]}],"id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003072","name":"LOEWE Zentrum AdRIA","doi-asserted-by":"publisher","award":["LOEWE\/1\/10\/519\/03\/03.001(0016)\/53"],"award-info":[{"award-number":["LOEWE\/1\/10\/519\/03\/03.001(0016)\/53"]}],"id":[{"id":"10.13039\/501100003072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00c3\u00a4t M\u00c3\u00bcnchen","doi-asserted-by":"publisher","award":["TI 07.003_DZIF_MD"],"award-info":[{"award-number":["TI 07.003_DZIF_MD"]}],"id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["AVH"],"award-info":[{"award-number":["AVH"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P 36299"],"award-info":[{"award-number":["P 36299"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Schistosomiasis, one of the most prevalent neglected tropical diseases, is treated exclusively with praziquantel, which targets only adult worms. High reinfection rates and the potential emergence of drug resistance emphasize the need for a deeper understanding of host-parasite developmental biology for innovative therapeutic targets. Most studies have focused on parasite-derived immunomodulators and proteolytic enzymes essential for host invasion, while the contribution of host-derived factors to parasite development has remained largely unexplored. Here, we identify and functionally characterize a host phospholipase that modulates parasite diacylglycerophospholipid metabolism and development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Large-scale proteomic screening identified host platelet-activating factor acetylhydrolase (PAFAH) as a candidate schistosomicidal factor. Using a mouse model of schistosomiasis, we produced recombinant mouse PAFAH (MsPAFAH) and performed\n                      <jats:italic>ex vivo<\/jats:italic>\n                      killing assays on juvenile stages and adult worms. Parasite morphology and reproductive organ integrity were assessed by confocal and scanning electron microscopy. Alterations in glycerophospholipid distribution were quantified by UPLC-MS\/MS-based fatty acid profiling, followed by rescue experiments with free fatty acid supplementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MsPAFAH was upregulated in schistosome-infected mice and exhibited potent schistosomicidal activity against all life stages in the host. MsPAFAH treatment led to profound impairments in worm fecundity, pairing stability, reproductive organ integrity, and stem cell development. This activity was associated with substantial sex-dependent changes in ether-phospholipid composition and distribution within the schistosome. MsPAFAH specifically decreased the availability of phospholipid species containing namely eicosenoic (20:1) and docosatetraenoic acid (22:4), while increasing levels of respective hydrolysis (lyso) products carrying 20:1 or stearic acid (18:0), predominantly in males. Supplementation of metabolized fatty acids C20:1\/eicosenoic acid and 22:4\/adrenic acid rescued the viability of female worms, confirming the essential role of the metabolism of these diacylglycerophospholipids in schistosome survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal a previously unrecognized host-derived regulator of schistosome development, highlighting phospholipid metabolism as a promising therapeutic axis for consideration in schistosomiasis interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.ppat.1014207","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:43:21Z","timestamp":1778607801000},"page":"e1014207","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Host-specific platelet-activating factor acetylhydrolase selectively remodels diacylglycerophospholipids to control schistosome development"],"prefix":"10.1371","volume":"22","author":[{"given":"Johanna","family":"Ertl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-706X","authenticated-orcid":true,"given":"Ulrich 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Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization","volume":"277","author":"D van der Kleij","year":"2002","journal-title":"J Biol Chem"},{"issue":"3","key":"ppat.1014207.ref082","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","article-title":"Lipid peroxidation in cell death","volume":"482","author":"MM Gaschler","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"ppat.1014207.ref083","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MCHD-0035-2016","article-title":"Lipid Mediators in Inflammation","volume":"4","author":"M Bennett","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"2","key":"ppat.1014207.ref084","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0166-6851(85)90019-2","article-title":"Renewal of the membrane complex of Schistosoma mansoni is closely associated with lipid metabolism","volume":"17","author":"HJ Vial","year":"1985","journal-title":"Mol Biochem Parasitol"},{"key":"ppat.1014207.ref085","article-title":"Comparative Metabonomic Investigations of from SCID mice and BALB\/c mice: clues to developmental abnormality of schistosome in the immunodeficient host","volume":"10","author":"R Liu","year":"2019","journal-title":"Front Microbiol"},{"issue":"5","key":"ppat.1014207.ref086","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00436-011-2386-4","article-title":"Scanning electron microscopy of the human low-density lipoprotein interaction with the tegument of Schistosoma mansoni","volume":"109","author":"ASA Pereira","year":"2011","journal-title":"Parasitol Res"},{"issue":"7253","key":"ppat.1014207.ref087","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke Schistosoma mansoni","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"key":"ppat.1014207.ref088","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0166-6851(97)00091-1","article-title":"The incorporation, modification and turnover of fatty acids in adult Schistosoma mansoni","volume":"88","author":"JF Brouwers","year":"1997","journal-title":"Mol Biochem Parasitol"},{"issue":"10","key":"ppat.1014207.ref089","article-title":"Fatty acid oxidation is essential for egg production by the parasitic flatworm Schistosoma mansoni","volume":"8","author":"SC-C Huang","year":"2012","journal-title":"PLoS Pathog"},{"issue":"5","key":"ppat.1014207.ref090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008145","article-title":"Tissue- and sex-specific lipidomic analysis of Schistosoma mansoni using high-resolution atmospheric pressure scanning microprobe matrix-assisted laser desorption\/ionization mass spectrometry imaging","volume":"14","author":"P Kadesch","year":"2020","journal-title":"PLoS Negl Trop Dis"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1014207","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:41:50Z","timestamp":1779212510000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014207"}},"subtitle":[],"editor":[{"given":"Michael H.","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":90,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,5,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1014207","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]}}}