{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T20:05:30Z","timestamp":1784405130049,"version":"3.55.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology (DBT), Ministry of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology (DST), Ministry of Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy","doi-asserted-by":"crossref","award":["DAE0195"],"award-info":[{"award-number":["DAE0195"]}],"id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Astra Chair Professorship Grant"},{"name":"TATA Innovation fellowship grant"},{"name":"DBT-IISc Partnership grant"},{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"crossref"}]},{"name":"DST"},{"name":"UGC-CAS"},{"name":"UGC Fellowship"},{"name":"IISc-MHRD fellowship"},{"name":"CSIR Fellowship"},{"DOI":"10.13039\/100007780","name":"IISc","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007780","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    The intestinal milieu is largely characterized by the complex array of chemical compounds produced through the metabolic activity of resident microbiota. Enteric pathogens like\n                    <jats:italic>Salmonella<\/jats:italic>\n                    , which have evolved refined mechanisms to persist within this environment, utilize these microbial metabolites and self-produce quorum molecules as molecular cues to identify ecological niches and modulate their survival and virulence strategies.\n                    <jats:italic>Salmonella<\/jats:italic>\n                    quorum sensing involves producing and detecting universal Autoinducer-2 (AI-2) signaling molecules. Our research reveals that\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium enhances AI-2 biosynthesis and transport under acidic conditions, aiding environmental adaptation and facilitating pathogenesis in macrophages. AI-2 signaling regulates the pH-sensing two-component system genes,\n                    <jats:italic>phoP\/phoQ<\/jats:italic>\n                    , ensuring cytosolic pH homeostasis, survival, and acid tolerance. It also involves regulating the lysine\/cadaverine-mediated acid tolerance response and maintaining bacterial cytosolic pH. Furthermore, we investigated the mechanism of AI-2-mediated gene regulation and demonstrated that, in addition to the\n                    <jats:italic>lsr<\/jats:italic>\n                    promoter, the repressor LsrR binds the\n                    <jats:italic>phoP<\/jats:italic>\n                    promoter via its Y25 and R43 residues, thereby negatively regulating\n                    <jats:italic>phoP<\/jats:italic>\n                    expression. Additionally, this signaling ameliorates the intracellular survival by modulating\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Pathogenicity Island-2 (SPI-2) regulators (\n                    <jats:italic>ssrA\/ssrB<\/jats:italic>\n                    ) and SPI-2 effector expression via PhoP. Mouse models demonstrate that AI-2 signaling is essential for colonizing the primary and secondary infection sites. Therefore, quorum sensing facilitates survival in hostile host environments by modulating multiple genetic targets through the AI-2\/LsrR-mediated feedback loop in pathogenic bacteria.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014244","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:28:48Z","timestamp":1779989328000},"page":"e1014244","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["LuxS\/AI-2 regulates phoP\/phoQ by a non-canonical mechanism to enhance acid stress survival in Salmonella Typhimurium"],"prefix":"10.1371","volume":"22","author":[{"given":"Anmol","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilash 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S.","family":"Rajmani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Varshney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-5145","authenticated-orcid":true,"given":"Dipshikha","family":"Chakravortty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"issue":"4","key":"ppat.1014244.ref001","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00610-22","article-title":"AI-2\/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish","volume":"10","author":"Z 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