{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:08:13Z","timestamp":1780423693842,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014282","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000}}],"reference-count":13,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R21AI173718"],"award-info":[{"award-number":["R21AI173718"]}]},{"name":"NIH","award":["R01AI040996, R37 AI035681, and R01 AI168370"],"award-info":[{"award-number":["R01AI040996, R37 AI035681, and R01 AI168370"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Innate lymphocytes and myeloid cells communicate and play an essential part in activating neutrophils and other effector cells to kill fungi. Here, we identified that Signaling Lymphocytic Activation Molecule 1 (SLAMF1) orchestrates a cellular and molecular signaling network that activates phagocytes. We uncovered innate lymphocytes including innate CD4\n                    <jats:sup>+<\/jats:sup>\n                    or TCR\u03b3\u03b4\n                    <jats:sup>+<\/jats:sup>\n                    T cells augment neutrophil killing of\n                    <jats:italic>Blastomyces dermatitidis<\/jats:italic>\n                    (\n                    <jats:italic>Bd<\/jats:italic>\n                    ) in a SLAMF1 dependent manner. SLAMF1 expression on neutrophils enabled homotypic SLAMF1:SLAMF1 interactions with innate CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells, which released soluble factors that activated neutrophils to kill fungi. Our work furnishes new mechanistic insight about the role of SLAMF1 in mobilizing innate immune cells to induce phagocyte-driven killing of inhaled fungi.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014282","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T17:40:41Z","timestamp":1779990041000},"page":"e1014282","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Homotypic interactions between SLAMF1 receptors on innate T cells and neutrophils regulate killing of fungi"],"prefix":"10.1371","volume":"22","author":[{"given":"Lindsay Suarez","family":"Lau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lichtenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleison Ledesma","family":"Taira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2781-7876","authenticated-orcid":true,"given":"Marcel","family":"W\u00fcthrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"issue":"4","key":"ppat.1014282.ref001","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1615\/CritRevImmunol.2014010538","article-title":"Role of SLAM family receptors and specific adapter SAP in innate-like lymphocytes","volume":"34","author":"X Romero","year":"2014","journal-title":"Crit Rev Immunol"},{"key":"ppat.1014282.ref002","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/bs.ai.2019.11.006","article-title":"Regulation of MHC class I-independent NK cell education by SLAM family receptors","volume":"145","author":"S Chen","year":"2020","journal-title":"Adv Immunol"},{"issue":"1","key":"ppat.1014282.ref003","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nri1761","article-title":"Immune regulation by SLAM family receptors and SAP-related adaptors","volume":"6","author":"A Veillette","year":"2006","journal-title":"Nat Rev Immunol"},{"issue":"6798","key":"ppat.1014282.ref004","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/35022579","article-title":"SLAM (CDw150) is a cellular receptor for measles virus","volume":"406","author":"H Tatsuo","year":"2000","journal-title":"Nature"},{"key":"ppat.1014282.ref005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fimmu.2016.00004","article-title":"Responses to Microbial Challenges by SLAMF Receptors","volume":"7","author":"BJ van Driel","year":"2016","journal-title":"Front 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Immunopharmacol"},{"issue":"4","key":"ppat.1014282.ref012","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.chom.2018.02.011","article-title":"Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection","volume":"23","author":"N Hern\u00e1ndez-Santos","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ppat.1014282.ref013","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.chom.2020.02.006","article-title":"Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation","volume":"27","author":"DL Wiesner","year":"2020","journal-title":"Cell Host Microbe"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1014282","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000}}],"container-title":["PLOS 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