{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T18:14:17Z","timestamp":1783707257914,"version":"3.55.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI148656"],"award-info":[{"award-number":["R01 AI148656"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35151045"],"award-info":[{"award-number":["R35151045"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM108563-06"],"award-info":[{"award-number":["T32 GM108563-06"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM154124-01"],"award-info":[{"award-number":["T32 GM154124-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Schistosomiasis, caused by parasitic worms, affects over 250 million people globally, with limited treatment options due to praziquantel\u2019s inability to prevent reinfection or reduce immunopathology. In\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    (\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    ) infection, egg-induced granulomatous inflammation in the liver and intestines is driven by CD4 T helper (Th) cell responses, with severe pathology in some individuals mediated by Th17 cell activation. We previously demonstrated that the stimulator of interferon genes (STING) mitigates schistosome egg-induced immunopathology by promoting type I Interferon (IFN-I) production and suppressing Th17 responses. Here, we investigate the therapeutic potential of the STING agonist diABZI-3 in a high-pathology CBA mouse model. In vitro, diABZI-3 pretreatment of bone marrow-derived dendritic cells (BMDCs) significantly enhanced IFN\u03b2 production while abolishing IL-1\u03b2 and IL-17 expression in response to schistosome egg stimulation, an effect dependent on early administration. In vivo, a single dose of diABZI-3 administered to\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    -infected CBA mice reduced liver and intestine granuloma size, lowered IL-1\u03b2, IL-17, and CD209a levels, promoted the Foxp3\u207a\u2009regulatory T cells, reduced Th17 recruitment, and mitigated inflammation-associated shifts in gut microbiota populations. Furthermore, blocking STING degradation with bafilomycin A1 sustained STING signaling, leading to pronounced IL-1\u03b2 suppression. These findings highlight diABZI-3 as a promising therapeutic agent for reducing schistosome-induced immunopathology.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014394","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:29:28Z","timestamp":1783704568000},"page":"e1014394","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["STING agonist protects against exacerbation of schistosome egg-induced immunopathology"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2741-5815","authenticated-orcid":true,"given":"Pengyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan 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E.","family":"Bisanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0159-474X","authenticated-orcid":true,"given":"Parisa","family":"Kalantari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"issue":"11","key":"ppat.1014394.ref001","article-title":"Review of 2022 WHO guidelines on the control and elimination of schistosomiasis","volume":"22","author":"NC Lo","year":"2022","journal-title":"Lancet Infect Dis"},{"issue":"9","key":"ppat.1014394.ref002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000485","article-title":"Schistosomiasis in Africa: an emerging tragedy in our new global health decade","volume":"3","author":"PJ Hotez","year":"2009","journal-title":"PLoS Negl Trop 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