{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:29:01Z","timestamp":1787596141088,"version":"build-2736575974"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014486","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Education, Australian Government"},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2028572"],"award-info":[{"award-number":["GNT2028572"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP220101938"],"award-info":[{"award-number":["DP220101938"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Horizontal gene transfer introduces foreign DNA that can disrupt cellular processes and is therefore subject to xenogeneic silencing by nucleoid-associated proteins such as H-NS and Hha. In Enterohaemorrhagic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (EHEC), prophages make up a large fraction of the accessory genome and encode many virulence factors, yet their expression must overcome this silencing. We identify a prophage-encoded small RNA (sRNA), HnrS, that functions as an anti-silencing factor by targeting the H-NS paralogue Hha. HnrS is a short (66-nt) sRNA that is enriched in the locus of enterocyte effacement (LEE\u207a)\n                    <jats:italic>E. coli<\/jats:italic>\n                    strains and present in up to nine copies in EHEC and Enteropathogenic\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (EPEC) genomes. HnrS base-pairs with the\n                    <jats:italic>hha<\/jats:italic>\n                    ribosome-binding site to inhibit translation, thereby modulating Hha\u2013H-NS repression of virulence loci including the LEE type III secretion system. Loss of HnrS alters motility, T3SS expression, and a subset of Hha-regulated genes. These findings reveal an RNA-based counter-silencing strategy encoded by prophage to relieve xenogenic silencing.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014486","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T17:40:47Z","timestamp":1787074847000},"page":"e1014486","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli"],"prefix":"10.1371","volume":"22","author":[{"given":"Pranita","family":"Poudyal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Sy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel 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