{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:05:12Z","timestamp":1789499112236,"version":"build-2803163510"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014578","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000}}],"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32500127"],"award-info":[{"award-number":["32500127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200124"],"award-info":[{"award-number":["32200124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>The E3 ubiquitin ligase TRIM23 is involved in diverse cellular processes, however, its function in antiviral defense against adenovirus remains unclear. Here, we identify a novel mechanism by which TRIM23 restricts human adenovirus type 5 (HAdV-C5) replication. TRIM23 expression was upregulated upon HAdV-C5 infection, and functional studies showed that its overexpression inhibited viral replication, while knockdown enhanced it. Mechanistically, TRIM23 interacts with the viral E1A protein and promotes its degradation through a mechanism dependent of its canonical E3 ligase activity. Moreover, TRIM23 recruits the selective autophagy receptor p62 promotes E1A degradation in a E1A ubiquitination-independent manner. Our results unveil a novel host defense pathway-the TRIM23-E1A-p62 axis-that highlights the role of selective autophagy in antiviral immunity.<\/jats:p>","DOI":"10.1371\/journal.ppat.1014578","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:46:42Z","timestamp":1788889602000},"page":"e1014578","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRIM23 prevents adenovirus replication by p62-mediated selective autophagic degradation of viral E1A protein"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5142-227X","authenticated-orcid":true,"given":"Nan","family":"Sun","sequence":"first","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]},{"name":"Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, School of Basic Medical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banruo","family":"Xia","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yin","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"Xuzhou Medical University","place":["Xuzhou, China"],"department":["Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, School of Basic Medical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Xie","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Fang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]},{"name":"Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaolei","family":"Ma","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]},{"name":"Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafei","family":"Chai","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]},{"name":"Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Institute, Cellular Therapeutics School of Medicine, Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]},{"name":"The Affiliated Hospital of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Center of Clinical Oncology"]},{"name":"Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"],"department":["Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"1","key":"ppat.1014578.ref001","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1556\/EuJMI.4.2014.1.2","article-title":"Human adenovirus: viral pathogen with increasing importance","volume":"4","author":"B Ghebremedhin","year":"2014","journal-title":"Eur J Microbiol Immunol (Bp)"},{"issue":"1","key":"ppat.1014578.ref002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.molmed.2022.10.001","article-title":"Adenoviruses in medicine: innocuous pathogen, predator, or partner","volume":"29","author":"KM MacNeil","year":"2023","journal-title":"Trends Mol Med"},{"issue":"11","key":"ppat.1014578.ref003","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01407-25","article-title":"ARGLU1 is a negative regulator of the adenoviral replicative cycle","volume":"99","author":"A Koul","year":"2025","journal-title":"J Virol"},{"issue":"22","key":"ppat.1014578.ref004","doi-asserted-by":"crossref","first-page":"13469","DOI":"10.1128\/JVI.02538-14","article-title":"Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth","volume":"88","author":"S Radko","year":"2014","journal-title":"J Virol"},{"issue":"14","key":"ppat.1014578.ref005","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00439-18","article-title":"Adenovirus 5 E1A-mediated suppression of p53 via FUBP1","volume":"92","author":"JR Frost","year":"2018","journal-title":"J Virol"},{"issue":"12","key":"ppat.1014578.ref006","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00993-23","article-title":"Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1\/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress","volume":"97","author":"NR Zemke","year":"2023","journal-title":"J Virol"},{"issue":"4","key":"ppat.1014578.ref007","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1128\/JVI.02392-15","article-title":"The dual nature of Nek9 in adenovirus replication","volume":"90","author":"R Jung","year":"2015","journal-title":"J Virol"},{"issue":"1","key":"ppat.1014578.ref008","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12929-023-00899-2","article-title":"The role of autophagy in viral infections","volume":"30","author":"T Chen","year":"2023","journal-title":"J Biomed Sci"},{"issue":"7182","key":"ppat.1014578.ref009","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"N Mizushima","year":"2008","journal-title":"Nature"},{"issue":"3","key":"ppat.1014578.ref010","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1080\/15548627.2022.2111635","article-title":"TMEM164 is a new determinant of autophagy-dependent ferroptosis","volume":"19","author":"J Liu","year":"2023","journal-title":"Autophagy"},{"key":"ppat.1014578.ref011","unstructured":"OASL suppresses infectious bursal disease virus replication by targeting VP2 for degrading through the autophagy pathway. 2024."},{"key":"ppat.1014578.ref012","doi-asserted-by":"crossref","first-page":"110169","DOI":"10.1016\/j.clim.2024.110169","article-title":"From homeostasis to defense: Exploring the role of selective autophagy in innate immunity and viral infections","volume":"262","author":"M Huang","year":"2024","journal-title":"Clin Immunol"},{"issue":"8","key":"ppat.1014578.ref013","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1080\/15548627.2023.2181615","article-title":"N protein of PEDV plays chess game with host proteins by selective autophagy","volume":"19","author":"X Zhai","year":"2023","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1014578.ref014","doi-asserted-by":"crossref","first-page":"2232707","DOI":"10.1080\/21505594.2023.2232707","article-title":"African swine fever virus protein p17 promotes mitophagy by facilitating the interaction of SQSTM1 with TOMM70","volume":"14","author":"B Hu","year":"2023","journal-title":"Virulence"},{"issue":"10","key":"ppat.1014578.ref015","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1080\/15548627.2024.2356505","article-title":"Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response","volume":"20","author":"Z-M Li","year":"2024","journal-title":"Autophagy"},{"issue":"2","key":"ppat.1014578.ref016","article-title":"TRIM proteins: New players in virus-induced autophagy","volume":"14","author":"KMJ Sparrer","year":"2018","journal-title":"PLoS Pathog"},{"issue":"1","key":"ppat.1014578.ref017","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41392-022-01152-2","article-title":"The RING finger protein family in health and disease","volume":"7","author":"C Cai","year":"2022","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"ppat.1014578.ref018","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/cr.2014.46","article-title":"Structural insights into the TRIM family of ubiquitin E3 ligases","volume":"24","author":"Y Li","year":"2014","journal-title":"Cell Res"},{"issue":"2","key":"ppat.1014578.ref019","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/v17020199","article-title":"TRIM38 inhibits Zika virus by upregulating RIG-I\/MDA5 pathway and promoting ubiquitin-mediated degradation of viral NS3 protein","volume":"17","author":"J He","year":"2025","journal-title":"Viruses"},{"issue":"6","key":"ppat.1014578.ref020","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jmb.2013.12.005","article-title":"TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity","volume":"426","author":"R Rajsbaum","year":"2014","journal-title":"J Mol Biol"},{"issue":"4","key":"ppat.1014578.ref021","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/15548627.2024.2426114","article-title":"Avian TRIM13 attenuates antiviral innate immunity by targeting MAVS for autophagic degradation","volume":"21","author":"P Zhou","year":"2025","journal-title":"Autophagy"},{"issue":"11","key":"ppat.1014578.ref022","article-title":"Tripartite motif 25 inhibits protein aggregate degradation during PRRSV infection by suppressing p62-mediated autophagy","volume":"98","author":"J Ren","year":"2024","journal-title":"J Virol"},{"issue":"2","key":"ppat.1014578.ref023","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/v13020320","article-title":"Human TRIM5\u03b1: autophagy connects cell-intrinsic HIV-1 restriction and innate immune sensor functioning","volume":"13","author":"APM Cloherty","year":"2021","journal-title":"Viruses"},{"issue":"12","key":"ppat.1014578.ref024","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.4161\/15548627.2014.984278","article-title":"TRIM proteins regulate autophagy: TRIM5 is a selective autophagy receptor mediating HIV-1 restriction","volume":"10","author":"MA Mandell","year":"2014","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1014578.ref025","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1038\/s41467-025-59338-5","article-title":"TRIM23 mediates cGAS-induced autophagy in anti-HSV defense","volume":"16","author":"D Acharya","year":"2025","journal-title":"Nat Commun"},{"issue":"11","key":"ppat.1014578.ref026","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41564-017-0017-2","article-title":"TRIM23 mediates virus-induced autophagy via activation of TBK1","volume":"2","author":"KMJ Sparrer","year":"2017","journal-title":"Nat Microbiol"},{"issue":"8","key":"ppat.1014578.ref027","article-title":"Inhibition of human adenovirus replication by TRIM35-mediated degradation of E1A","volume":"97","author":"N Sun","year":"2023","journal-title":"J Virol"},{"issue":"7","key":"ppat.1014578.ref028","article-title":"TRIM56 enhances adenoviral E1A steady state to improve oncolytic adenovirus therapy efficacy","volume":"99","author":"N Sun","year":"2025","journal-title":"J Virol"},{"issue":"8","key":"ppat.1014578.ref029","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot095562","article-title":"Measuring the infectious titer of recombinant adenovirus using tissue culture infection dose 50% (TCID50) end-point dilution and quantitative polymerase chain reaction (qPCR)","volume":"2019","author":"M Lock","year":"2019","journal-title":"Cold Spring Harb Protoc"},{"issue":"11","key":"ppat.1014578.ref030","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"K Ozato","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"ppat.1014578.ref031","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.biochem.78.081507.101607","article-title":"Recognition and processing of ubiquitin-protein conjugates by the proteasome","volume":"78","author":"D Finley","year":"2009","journal-title":"Annu Rev Biochem"},{"issue":"2","key":"ppat.1014578.ref032","article-title":"TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein","volume":"20","author":"B Sui","year":"2024","journal-title":"PLoS Pathog"},{"issue":"15","key":"ppat.1014578.ref033","doi-asserted-by":"crossref","first-page":"5404","DOI":"10.1074\/jbc.TM117.000117","article-title":"Ubiquitin signaling and autophagy","volume":"293","author":"P Grumati","year":"2018","journal-title":"J Biol Chem"},{"key":"ppat.1014578.ref034","unstructured":"March6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation. 2025."},{"issue":"4","key":"ppat.1014578.ref035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nsmb.2780","article-title":"New insights into ubiquitin E3 ligase mechanism","volume":"21","author":"CE Berndsen","year":"2014","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"ppat.1014578.ref036","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-virology-092917-043323","article-title":"TRIM proteins and their roles in antiviral host defenses","volume":"5","author":"M van Gent","year":"2018","journal-title":"Annu Rev Virol"},{"issue":"7","key":"ppat.1014578.ref037","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1080\/15548627.2026.2659292","article-title":"EXOC5\/SEC10 attenuates antiviral IFN-I signaling by targeting STING1 for autophagic degradation","volume":"22","author":"W Ma","year":"2026","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1014578.ref038","doi-asserted-by":"crossref","first-page":"104639","DOI":"10.1016\/j.psj.2024.104639","article-title":"The PB1 protein of H9N2 influenza A virus inhibits antiviral innate immunity by targeting MAVS for TRIM25-mediated autophagic degradation","volume":"104","author":"J Luo","year":"2025","journal-title":"Poult Sci"},{"issue":"5","key":"ppat.1014578.ref039","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2009.04.006","article-title":"Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I","volume":"5","author":"MU Gack","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"18","key":"ppat.1014578.ref040","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1128\/JVI.02593-13","article-title":"TRIM13 is a negative regulator of MDA5-mediated type I interferon production","volume":"88","author":"K Narayan","year":"2014","journal-title":"J Virol"},{"issue":"10","key":"ppat.1014578.ref041","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.1128\/JVI.02032-10","article-title":"Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity","volume":"85","author":"H Jiang","year":"2011","journal-title":"J Virol"},{"key":"ppat.1014578.ref042","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.virol.2011.04.017","article-title":"Adenoviruses induce autophagy to promote virus replication and oncolysis","volume":"416","author":"H Rodriguez-Rocha","year":"2011","journal-title":"Virology"},{"issue":"1","key":"ppat.1014578.ref043","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948317","article-title":"TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease","volume":"21","author":"L Herhaus","year":"2020","journal-title":"EMBO Rep"},{"issue":"5","key":"ppat.1014578.ref044","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/15548627.2019.1580513","article-title":"The emerging role of human TBK1 in virus-induced autophagy","volume":"15","author":"A Liyana","year":"2019","journal-title":"Autophagy"},{"issue":"15","key":"ppat.1014578.ref045","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1073\/pnas.1523926113","article-title":"Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria","volume":"113","author":"B Richter","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"ppat.1014578.ref046","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1093\/hmg\/ddv179","article-title":"TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62\/SQSTM1 phosphorylation","volume":"24","author":"G Matsumoto","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ppat.1014578.ref047","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2015.08.016","article-title":"The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN\/NDP52 recruitment and tbk1 activation to promote mitophagy","volume":"60","author":"J-M Heo","year":"2015","journal-title":"Mol Cell"},{"issue":"36","key":"ppat.1014578.ref048","doi-asserted-by":"crossref","first-page":"15856","DOI":"10.1073\/pnas.1004621107","article-title":"Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense","volume":"107","author":"K Arimoto","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ppat.1014578.ref049","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.chom.2014.07.015","article-title":"The interferon signaling antagonist function of yellow fever virus NS5 protein is activated by type I interferon","volume":"16","author":"M Laurent-Rolle","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ppat.1014578.ref050","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1080\/15548627.2016.1154254","article-title":"TRIM-directed selective autophagy regulates immune activation","volume":"13","author":"T Kimura","year":"2017","journal-title":"Autophagy"},{"issue":"1","key":"ppat.1014578.ref051","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41467-022-28171-5","article-title":"Galectin-9 restricts hepatitis B virus replication via p62\/SQSTM1-mediated selective autophagy of viral core proteins","volume":"13","author":"K Miyakawa","year":"2022","journal-title":"Nat Commun"},{"issue":"8","key":"ppat.1014578.ref052","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms13081865","article-title":"BST-2 promotes N protein degradation and inhibits viral replication through the MARCHF8\/NDP52 autophagy pathway","volume":"13","author":"C Zhao","year":"2025","journal-title":"Microorganisms"},{"issue":"9","key":"ppat.1014578.ref053","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrd4663","article-title":"Oncolytic viruses: a new class of immunotherapy drugs","volume":"14","author":"HL Kaufman","year":"2015","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"ppat.1014578.ref054","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/mt.2015.194","article-title":"Development of Novel Adenoviral Vectors to Overcome Challenges Observed With HAdV-5-based Constructs","volume":"24","author":"J Alonso-Padilla","year":"2016","journal-title":"Mol Ther"},{"issue":"19","key":"ppat.1014578.ref055","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1007\/s00253-016-7806-z","article-title":"Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy","volume":"100","author":"S Li","year":"2016","journal-title":"Appl Microbiol Biotechnol"},{"issue":"5","key":"ppat.1014578.ref056","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s11262-017-1488-1","article-title":"Oncolytic viruses: adenoviruses","volume":"53","author":"J Niemann","year":"2017","journal-title":"Virus Genes"},{"issue":"6","key":"ppat.1014578.ref057","doi-asserted-by":"crossref","first-page":"8636","DOI":"10.1002\/jcp.27850","article-title":"Oncolytic adenovirus: A tool for cancer therapy in combination with other therapeutic approaches","volume":"234","author":"NH Goradel","year":"2019","journal-title":"J Cell Physiol"},{"key":"ppat.1014578.ref058","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.omto.2021.11.014","article-title":"Current development in adenoviral vectors for cancer immunotherapy","volume":"23","author":"GWG Biegert","year":"2021","journal-title":"Mol Ther Oncolytics"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1014578","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:28:02Z","timestamp":1789496882000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014578"}},"subtitle":[],"editor":[{"given":"Eain A","family":"Murphy","sequence":"first","affiliation":[{"name":"State University of New York Upstate Medical University","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1014578","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]}}}