{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:14:17Z","timestamp":1792458857582,"version":"4.5.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB0730300"],"award-info":[{"award-number":["XDB0730300"]}],"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) is one of the regulatory subunits of protein phosphatase 1 (PP1). Current research on PPP1R3G is primarily focused on glycogen synthesis and lipid metabolism. However, the role of\n                    <jats:italic>ppp1r3g<\/jats:italic>\n                    in the innate immune response of fish has not been completely elucidated. This study demonstrated that\n                    <jats:italic>ppp1r3g<\/jats:italic>\n                    regulates RLR signaling pathway through interactions with Rig-I, Mda5, and Traf6. In parallel, Ppp1r3g inhibits platelet activation by regulating 14-3-3 zeta (14-3-3\u03b6) and consequently modulating the formation of the 14-3-3\u03b6-integrin-\u03b23 (Itgb3) complex.\n                    <jats:italic>In vivo<\/jats:italic>\n                    analysis revealed that compared with the wild-type controls,\n                    <jats:italic>ppp1r3g<\/jats:italic>\n                    -null rare minnow (\n                    <jats:italic>Gobiocypris rarus<\/jats:italic>\n                    ) and\n                    <jats:italic>ppp1r3g<\/jats:italic>\n                    -chimera grass carp (\n                    <jats:italic>Ctenopharyngodon idella<\/jats:italic>\n                    ) exhibited significantly enhanced resistance to grass carp reovirus (GCRV), with markedly alleviated hemorrhagic symptoms post-infection. Furthermore, knockdown of\n                    <jats:italic>ppp1r3g<\/jats:italic>\n                    suppressed GCRV replication and upregulated type I interferon (IFN-1) expression in grass carp kidney (CIK) cells. Additionally, Ppp1r3g binds to the -ESKVFYLKMKGDYYRYL- fragment (EL17) of 14-3-3\u03b6\n                    <jats:italic>via<\/jats:italic>\n                    the Ser36\/37 phosphorylation site located on the PP1c domain. This study also demonstrated that 14-3-3\u03b6 interacts with Itgb3 through this fragment, indicating that Ppp1r3g competes with Itgb3 to bind 14-3-3\u03b6. Furthermore, Ppp1r3g dose-dependently promoted Itgb3 degradation via a proteolytic pathway. These findings indicate that Ppp1r3g negatively regulates innate antiviral immunity after GCRV stimulation and suppresses platelet and coagulation cascade activation by modulating the interaction between 14-3-3\u03b6 and Itgb3 in fish.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014590","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:23:00Z","timestamp":1789752180000},"page":"e1014590","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Grass carp reovirus activates fish Ppp1r3g to suppress innate immunity and exacerbate hemorrhage via the 14-3-3\u03b6\/Itgb3 signaling axis"],"prefix":"10.1371","volume":"22","author":[{"given":"Ruyi","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"Hunan Agricultural University","place":["Changsha, China"],"department":["Fisheries College"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-544X","authenticated-orcid":true,"given":"Hong","family":"Cao","sequence":"additional","affiliation":[{"name":"Institute of Hydrobiology, Chinese Academy of Sciences","place":["Wuhan, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ppat.1014590.ref001","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1146\/annurev-immunol-042617-053309","article-title":"RIG-I and other RNA sensors in antiviral 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