{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:55:02Z","timestamp":1791485702616,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014621","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"reference-count":126,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI159307"],"award-info":[{"award-number":["R21AI159307"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI153083"],"award-info":[{"award-number":["R01AI153083"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI173171"],"award-info":[{"award-number":["R01AI173171"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI175134"],"award-info":[{"award-number":["R01AI175134"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R61AI187100"],"award-info":[{"award-number":["R61AI187100"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    is the second most prevalent\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    species, with 2.5 billion people at risk of infection worldwide and around 10 million cases of clinical vivax malaria every year. Despite the clinical importance of this pathogen, little is known about the\n                    <jats:italic>P. vivax<\/jats:italic>\n                    proteins recognized by the host immune system, which hinders our ability to select vaccine candidates or to develop efficient serological markers. To characterize immunogenic\n                    <jats:italic>P. vivax<\/jats:italic>\n                    proteins, we designed a high-density peptide array containing 4.2 million peptides covering the entire protein sequences of all\n                    <jats:italic>P. vivax<\/jats:italic>\n                    genes and analyzed antibody responses of infected and malaria-na\u00efve individuals. We identified a total of 283 proteins that are commonly immunogenic in symptomatic individuals. These proteins included many proteins known to be involved in erythrocyte invasion, several nucleoporins, and many uncharacterized proteins that should be further investigated for their roles during blood-stage infections. These analyses also revealed a unique pattern of antibody response against PIR proteins in asymptomatic individuals that could be associated with protection against clinical vivax malaria. Overall, these data provide an agnostic and proteome-wide perspective on immunogenic\n                    <jats:italic>P. vivax<\/jats:italic>\n                    proteins and constitute an important resource for the malaria community to develop new tools for better detecting and eliminating this important human pathogen.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014621","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:52:30Z","timestamp":1790617950000},"page":"e1014621","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteome-wide characterization of Plasmodium vivax antigens using a high-density peptide array"],"prefix":"10.1371","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-2293","authenticated-orcid":true,"given":"Rosita","family":"Asawa","sequence":"first","affiliation":[{"name":"Institute for Genome Sciences, 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America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tan","sequence":"additional","affiliation":[{"name":"Nimble Therapeutics Inc.","place":["Madison, Wisconsin, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"Cantaert","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge","place":["Phnom Penh, Cambodia"],"department":["Immunology Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Berry","sequence":"additional","affiliation":[{"name":"University of Maryland School of Medicine","place":["Baltimore, Maryland, United States of America"],"department":["Center for Vaccine Development"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj","family":"Tolia","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases","place":["Bethesda, Maryland, United States of America"],"department":["Laboratory of Malaria Immunology and Vaccinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Popovici","sequence":"additional","affiliation":[{"name":"Institut Pasteur du Cambodge","place":["Phnom Penh, Cambodia"],"department":["Malaria Research Unit"]},{"name":"Institut Pasteur","place":["Paris, France"],"department":["Infectious Disease Epidemiology and Analytics G5 Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-9095","authenticated-orcid":true,"given":"David","family":"Serre","sequence":"additional","affiliation":[{"name":"Institute for Genome Sciences, University of Maryland School of Medicine","place":["Baltimore, Maryland, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"ppat.1014621.ref001","doi-asserted-by":"crossref","DOI":"10.30875\/9789287074560","volume-title":"World 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