{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:00:25Z","timestamp":1791223225800,"version":"4.1.0"},"reference-count":20,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"DOI":"10.1371\/journal.ppat.1014658","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:42:22Z","timestamp":1791222142000},"page":"e1014658","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Born to resist: Understanding natural resistance to Haemonchus contortus in sheep"],"prefix":"10.1371","volume":"22","author":[{"given":"Hannah","family":"Teddleton","sequence":"first","affiliation":[{"name":"University of Tennessee","place":["Knoxville, Tennessee, United States of America"],"department":["Department of Animal Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4153-2774","authenticated-orcid":true,"given":"Elizabeth","family":"Shepherd","sequence":"additional","affiliation":[{"name":"University of Tennessee","place":["Knoxville, Tennessee, United States of America"],"department":["Department of Animal Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"issue":"12","key":"ppat.1014658.ref001","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.ijpara.2016.07.001","article-title":"Haemonchus contortus: The then and now, and where to from here?","volume":"46","author":"DL Emery","year":"2016","journal-title":"Int J Parasitol"},{"issue":"3","key":"ppat.1014658.ref002","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cvfa.2006.07.006","article-title":"Gastrointestinal nematodes of small ruminants: Life cycle, anthelmintics, and diagnosis","volume":"22","author":"AM Zajac","year":"2006","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"8","key":"ppat.1014658.ref003","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.biotechadv.2013.01.008","article-title":"Advances in the diagnosis of key gastrointestinal nematode infections of livestock, with an emphasis on small ruminants","volume":"31","author":"F Roeber","year":"2013","journal-title":"Biotechnol Adv"},{"key":"ppat.1014658.ref004","doi-asserted-by":"crossref","first-page":"110394","DOI":"10.1016\/j.vetpar.2025.110394","article-title":"A systematic review of the molecular mechanisms related to anthelmintic resistance in Haemonchus contortus: A contemporary narrative","volume":"334","author":"JFV Rodrigues","year":"2025","journal-title":"Vet Parasitol"},{"issue":"1","key":"ppat.1014658.ref005","doi-asserted-by":"crossref","first-page":"14143","DOI":"10.1038\/s41598-025-97931-2","article-title":"Genetic diversity and adaptability of native sheep breeds from different climatic zones","volume":"15","author":"G Wanjala","year":"2025","journal-title":"Sci Rep"},{"issue":"3","key":"ppat.1014658.ref006","first-page":"422","article-title":"A study of the inheritance of resistance to trichostrongylidosis in sheep","volume":"45","author":"JH Whitlock","year":"1955","journal-title":"Cornell Vet"},{"issue":"3","key":"ppat.1014658.ref007","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0921-4488(02)00279-1","article-title":"Responses of hair and wool sheep to a single fixed dose of infective larvae of Haemonchus contortus","volume":"47","author":"DR Notter","year":"2003","journal-title":"Small Rumin Res"},{"key":"ppat.1014658.ref008","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0304-4017(92)90081-J","article-title":"Resistance of St. Croix lambs to Haemonchus contortus in experimentally and naturally acquired infections","volume":"41","author":"HR Gamble","year":"1992","journal-title":"Vet Parasitol"},{"issue":"1","key":"ppat.1014658.ref009","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0020-7519(85)90107-9","article-title":"Resistance of exotic and domestic lambs to experimental infection with Haemonchus contortus","volume":"15","author":"CH Courtney","year":"1985","journal-title":"Int J Parasitol"},{"issue":"11","key":"ppat.1014658.ref010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/pim.12054","article-title":"Causes and consequences of intra- and inter-host heterogeneity in defence against nematodes","volume":"35","author":"AD Hayward","year":"2013","journal-title":"Parasite Immunol"},{"issue":"5","key":"ppat.1014658.ref011","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1093\/jas\/sky064","article-title":"Genetic parameters for fecal egg counts and their relationship with body weights in Katahdin lambs","volume":"96","author":"L Ngere","year":"2018","journal-title":"J Anim Sci"},{"key":"ppat.1014658.ref012","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2527\/ssasas2017.0105","article-title":"Sire\u2019s Estimated Breeding Value (EBV) for Fecal Egg Count (FEC) influences BW, FEC, and anemia measures of offspring in katahdin sheep","volume":"95","author":"JM Burke","year":"2016","journal-title":"J Anim Sci"},{"issue":"1","key":"ppat.1014658.ref013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12711-019-0479-1","article-title":"Detection of genomic regions underlying resistance to gastrointestinal parasites in Australian sheep","volume":"51","author":"M Al Kalaldeh","year":"2019","journal-title":"Genet Sel Evol"},{"issue":"1","key":"ppat.1014658.ref014","doi-asserted-by":"crossref","first-page":"19579","DOI":"10.1038\/s41598-019-55447-6","article-title":"Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response","volume":"9","author":"C Escribano","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"ppat.1014658.ref015","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1051\/vetres:2006022","article-title":"Haemonchus contortus (Nematoda: Trichostrongylidae) infection in lambs elicits an unequivocal Th2 immune response","volume":"37","author":"C Lacroux","year":"2006","journal-title":"Vet Res"},{"key":"ppat.1014658.ref016","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.vetpar.2005.12.026","article-title":"Effect of CD4+ T lymphocyte depletion on resistance of Gulf Coast Native lambs to Haemonchus contortus infection","volume":"138","author":"MT Pe\u00f1a","year":"2006","journal-title":"Vet Parasitol"},{"key":"ppat.1014658.ref017","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.vetpar.2015.01.019","article-title":"St. Croix sheep produce a rapid and greater cellular immune response contributing to reduced establishment of Haemonchus contortus","volume":"208","author":"SA Bowdridge","year":"2015","journal-title":"Vet Parasitol"},{"issue":"1","key":"ppat.1014658.ref018","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cvfa.2019.11.007","article-title":"Sustainable approaches to parasite control in ruminant livestock","volume":"36","author":"JM Burke","year":"2020","journal-title":"Vet Clin North Am Food Anim Pract"},{"key":"ppat.1014658.ref019","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vetpar.2010.11.012","article-title":"Persistence of the efficacy of copper oxide wire particles against Haemonchus contortus in sheep","volume":"176","author":"AJ Galindo-Barboza","year":"2011","journal-title":"Vet Parasitol"},{"key":"ppat.1014658.ref020","doi-asserted-by":"crossref","first-page":"109386","DOI":"10.1016\/j.vetpar.2021.109386","article-title":"Protective efficacy of Barbervax in Merino weaner sheep trickle infected with five doses of Haemonchus contortus infective larvae","volume":"292","author":"MM Kebeta","year":"2021","journal-title":"Vet Parasitol"}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:42:24Z","timestamp":1791222144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014658"}},"subtitle":[],"editor":[{"given":"Laura J.","family":"Knoll","sequence":"first","affiliation":[{"name":"University of Wisconsin Medical School","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,5]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1014658","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,5]]}}}