{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:55:30Z","timestamp":1791485730808,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014665","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K22 CA241355"],"award-info":[{"award-number":["K22 CA241355"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30 GM103625"],"award-info":[{"award-number":["P30 GM103625"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015220","name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015220","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM103429"],"award-info":[{"award-number":["P20 GM103429"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Kaposi\u2019s sarcoma-associated herpesvirus (KSHV) causes several malignancies in people with HIV including Kaposi\u2019s sarcoma and primary effusion lymphoma (PEL). We have previously shown that PEL cell lines require myeloid cell leukemia-1 (MCL1) to inhibit apoptosis. MCL1 is an oncogene that is amplified in cancers and causes resistance to chemotherapy regimens. MCL1 is thus an attractive target for drug development. The emerging clinical relevance and therapeutic potential of MCL1 motivated us to study the roles of this oncogene in PEL in depth. Using a systems biology approach, we uncovered an unexpected genetic interaction between\n                    <jats:italic>MCL1<\/jats:italic>\n                    and\n                    <jats:italic>MARCHF5<\/jats:italic>\n                    indicating that they function in the same pathway. MARCHF5 is an E3 ubiquitin ligase best known for regulating mitochondrial homeostasis and antiviral signaling, but not apoptosis. We thus investigated how MCL1 and MARCHF5 cooperate to promote PEL cell survival. CRISPR knockout (KO) of\n                    <jats:italic>MARCHF5<\/jats:italic>\n                    in PEL cell lines resulted in a significant increase in apoptosis despite the presence of MCL1. The anti-apoptotic function of MARCHF5 was dependent on its E3 ligase and dimerization activities. Loss of MARCHF5 or inhibition of the 26S proteasome furthermore stabilized the MCL1 antagonist NOXA without affecting levels of MCL1. Interestingly,\n                    <jats:italic>NOXA<\/jats:italic>\n                    KO provides a fitness advantage to PEL cells suggesting that NOXA is the pro-apoptotic signal that necessitates the anti-apoptotic activities of MCL1 and MARCHF5. Endogenous reciprocal co-immunoprecipitation experiments show that MARCHF5 and NOXA are found in the same protein complex. Finally,\n                    <jats:italic>NOXA<\/jats:italic>\n                    KO rescued the loss of cell viability due to\n                    <jats:italic>MARCHF5<\/jats:italic>\n                    KO. Our findings thus provide the mechanistic link that underlies the genetic interaction between MCL1 and MARCHF5. We propose that MARCHF5 induces the degradation of the MCL1 antagonist NOXA thus reinforcing the pro-survival role of MCL1 in these tumor cells. This newly appreciated interaction of the MCL1 and MARCHF5 oncogenes may be useful to improve the design of combination therapies for KSHV malignancies.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014665","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:42:37Z","timestamp":1790876557000},"page":"e1014665","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The mitochondrial ubiquitin ligase MARCHF5 cooperates with MCL1 to inhibit apoptosis in KSHV-transformed primary effusion lymphoma cell lines"],"prefix":"10.1371","volume":"22","author":[{"given":"Prasanth","family":"Viswanathan","sequence":"first","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine R.","family":"Bersonda","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Gill","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssandra","family":"Navarro","sequence":"additional","affiliation":[{"name":"Program in Biomedical Engineering, University of Arkansas","place":["Fayetteville, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison C.","family":"Farrar","sequence":"additional","affiliation":[{"name":"Program in Health Sciences and Interdisciplinary Studies, Hendrix College","place":["Conway, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Caldarera","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Murphy","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Dunham","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl W.","family":"Boehme","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-7961","authenticated-orcid":true,"given":"Mark","family":"Manzano","sequence":"additional","affiliation":[{"name":"University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"],"department":["Department of Microbiology and Immunology"]},{"name":"Center for Microbial Pathogenesis and Host Inflammatory Responses, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]},{"name":"Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences","place":["Little Rock, Arkansas, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"7","key":"ppat.1014665.ref001","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood.2020005470","article-title":"KSHV\/HHV8-mediated hematologic diseases","volume":"139","author":"E Cesarman","year":"2022","journal-title":"Blood"},{"issue":"18","key":"ppat.1014665.ref002","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199505043321802","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas","volume":"332","author":"E Cesarman","year":"1995","journal-title":"N Engl J Med"},{"issue":"11","key":"ppat.1014665.ref003","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/01.pas.0000138177.10829.5c","article-title":"KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma","volume":"28","author":"A Chadburn","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"ppat.1014665.ref004","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V88.2.645.bloodjournal882645","article-title":"Primary effusion lymphoma: A distinct clinicopathologic entity associated with the Kaposi\u2019s sarcoma-associated herpes virus","volume":"88","author":"RG Nador","year":"1996","journal-title":"Blood"},{"issue":"21","key":"ppat.1014665.ref005","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1200\/JCO.2003.06.013","article-title":"Clinical features and outcome of primary effusion lymphoma in HIV-infected patients: A single-institution study","volume":"21","author":"C Simonelli","year":"2003","journal-title":"J Clin Oncol"},{"issue":"2","key":"ppat.1014665.ref006","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ajh.24251","article-title":"Classic and extracavitary primary effusion lymphoma in 51 HIV-infected patients from a single institution","volume":"91","author":"S Guillet","year":"2016","journal-title":"Am J Hematol"},{"issue":"12","key":"ppat.1014665.ref007","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.3109\/10428194.2012.694075","article-title":"Prognosis in primary effusion lymphoma is associated with the number of body cavities involved","volume":"53","author":"JJ Castillo","year":"2012","journal-title":"Leuk Lymphoma"},{"issue":"16","key":"ppat.1014665.ref008","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1182\/blood-2019-01-893339","article-title":"Viral, immunologic, and clinical features of primary effusion lymphoma","volume":"133","author":"K Lurain","year":"2019","journal-title":"Blood"},{"issue":"19","key":"ppat.1014665.ref009","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1200\/JCO.2005.07.084","article-title":"Prognostic factors and outcome of human herpesvirus 8-associated primary effusion lymphoma in patients with AIDS","volume":"23","author":"E Boulanger","year":"2005","journal-title":"J Clin Oncol"},{"issue":"11","key":"ppat.1014665.ref010","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1182\/blood.2019003959","article-title":"Impact of Myc in HIV-associated non-Hodgkin lymphomas treated with EPOCH and outcomes with vorinostat (AMC-075 trial)","volume":"136","author":"JC Ramos","year":"2020","journal-title":"Blood"},{"issue":"1","key":"ppat.1014665.ref011","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/(SICI)1098-2264(199901)24:1<16::AID-GCC3>3.0.CO;2-F","article-title":"Genetic characterization of HHV-8\/KSHV-positive primary effusion lymphoma reveals frequent mutations of BCL6: Implications for disease pathogenesis and histogenesis","volume":"24","author":"G Gaidano","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"issue":"3","key":"ppat.1014665.ref012","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1386-6532(99)00082-7","article-title":"Molecular characterization of HHV-8 positive primary effusion lymphoma reveals pathogenetic and histogenetic features of the disease","volume":"16","author":"G Gaidano","year":"2000","journal-title":"J Clin Virol"},{"issue":"4","key":"ppat.1014665.ref013","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1128\/JVI.01757-06","article-title":"Functional p53 signaling in Kaposi\u2019s sarcoma-associated herpesvirus lymphomas: Implications for therapy","volume":"81","author":"CE Petre","year":"2007","journal-title":"J Virol"},{"issue":"44","key":"ppat.1014665.ref014","article-title":"Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma","volume":"111","author":"DM Yang","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"ppat.1014665.ref015","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1038\/s41467-018-05506-9","article-title":"Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma","volume":"9","author":"M Manzano","year":"2018","journal-title":"Nat Commun"},{"key":"ppat.1014665.ref016","doi-asserted-by":"crossref","DOI":"10.1016\/j.coviro.2022.101270","article-title":"Druggable host gene dependencies in primary effusion lymphoma","volume":"56","author":"N Kuehnle","year":"2022","journal-title":"Curr Opin Virol"},{"issue":"7283","key":"ppat.1014665.ref017","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/nature08822","article-title":"The landscape of somatic copy-number alteration across human cancers","volume":"463","author":"R Beroukhim","year":"2010","journal-title":"Nature"},{"issue":"9","key":"ppat.1014665.ref018","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.humpath.2004.04.018","article-title":"MCL-1 expression in B-cell non-Hodgkin\u2019s lymphomas","volume":"35","author":"JH Cho-Vega","year":"2004","journal-title":"Hum Pathol"},{"issue":"1","key":"ppat.1014665.ref019","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1365-2141.2002.03253.x","article-title":"High expression of MCL1 gene related to vascular endothelial growth factor is associated with poor outcome in non-Hodgkin\u2019s lymphoma","volume":"116","author":"K Kuramoto","year":"2002","journal-title":"Br J Haematol"},{"issue":"7626","key":"ppat.1014665.ref020","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature19830","article-title":"The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models","volume":"538","author":"A Kotschy","year":"2016","journal-title":"Nature"},{"issue":"13","key":"ppat.1014665.ref021","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1182\/blood.2020006785","article-title":"BCL2 and MCL1 inhibitors for hematologic malignancies","volume":"138","author":"AW Roberts","year":"2021","journal-title":"Blood"},{"issue":"2","key":"ppat.1014665.ref022","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","article-title":"Cell death","volume":"187","author":"K Newton","year":"2024","journal-title":"Cell"},{"issue":"4","key":"ppat.1014665.ref023","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036319","article-title":"BAX, BAK, and BOK: A coming of age for the BCL-2 family effector proteins","volume":"12","author":"T Moldoveanu","year":"2020","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"23","key":"ppat.1014665.ref024","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01360-22","article-title":"Expression ratios of the antiapoptotic BCL2 family members dictate the selective addiction of Kaposi\u2019s sarcoma-associated herpesvirus-transformed primary effusion lymphoma cell lines to MCL1","volume":"96","author":"D Dunham","year":"2022","journal-title":"J Virol"},{"issue":"1","key":"ppat.1014665.ref025","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41598-022-04916-6","article-title":"Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma","volume":"12","author":"H Quentmeier","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"ppat.1014665.ref026","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus latency-associated nuclear antigen dysregulates expression of MCL-1 by targeting FBW7","volume":"17","author":"YJ Kim","year":"2021","journal-title":"PLoS Pathog"},{"issue":"3","key":"ppat.1014665.ref027","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.06.010","article-title":"Defining a cancer dependency map","volume":"170","author":"A Tsherniak","year":"2017","journal-title":"Cell"},{"issue":"5","key":"ppat.1014665.ref028","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.01.013","article-title":"Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic ras","volume":"168","author":"T Wang","year":"2017","journal-title":"Cell"},{"issue":"5","key":"ppat.1014665.ref029","article-title":"Interrogation of mammalian protein complex structure, function, and membership using genome-scale fitness screens","volume":"6","author":"J Pan","year":"2018","journal-title":"Cell Syst"},{"issue":"5","key":"ppat.1014665.ref030","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/s41588-021-00840-z","article-title":"A genome-wide atlas of co-essential modules assigns function to uncharacterized genes","volume":"53","author":"M Wainberg","year":"2021","journal-title":"Nat Genet"},{"issue":"15","key":"ppat.1014665.ref031","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1038\/sj.emboj.7601249","article-title":"A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics","volume":"25","author":"R Yonashiro","year":"2006","journal-title":"EMBO J"},{"issue":"10","key":"ppat.1014665.ref032","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1038\/sj.embor.7400790","article-title":"MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology","volume":"7","author":"N Nakamura","year":"2006","journal-title":"EMBO Rep"},{"key":"ppat.1014665.ref033","doi-asserted-by":"crossref","first-page":"7910","DOI":"10.1038\/ncomms8910","article-title":"The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling","volume":"6","author":"YS Yoo","year":"2015","journal-title":"Nat Commun"},{"issue":"13","key":"ppat.1014665.ref034","doi-asserted-by":"crossref","first-page":"15986","DOI":"10.18632\/oncotarget.7558","article-title":"Inhibition of MARCH5 ubiquitin ligase abrogates MCL1-dependent resistance to BH3 mimetics via NOXA","volume":"7","author":"A Subramanian","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"ppat.1014665.ref035","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1038\/s41418-020-0517-0","article-title":"MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex","volume":"27","author":"TM Djajawi","year":"2020","journal-title":"Cell Death Differ"},{"key":"ppat.1014665.ref036","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54954","article-title":"MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation","volume":"9","author":"S Arai","year":"2020","journal-title":"Elife"},{"issue":"3","key":"ppat.1014665.ref037","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1091\/mbc.e16-04-0208","article-title":"Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics","volume":"28","author":"E Cherok","year":"2017","journal-title":"Mol Biol Cell"},{"issue":"4","key":"ppat.1014665.ref038","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01457-20","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus drives a super-enhancer-mediated survival gene expression program in primary effusion lymphoma","volume":"11","author":"M Manzano","year":"2020","journal-title":"mBio"},{"issue":"2","key":"ppat.1014665.ref039","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/febs.13568","article-title":"Self-clearance mechanism of mitochondrial E3 ligase MARCH5 contributes to mitochondria quality control","volume":"283","author":"SH Kim","year":"2016","journal-title":"FEBS J"},{"issue":"1","key":"ppat.1014665.ref040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1083\/jcb.200611064","article-title":"The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division","volume":"178","author":"M Karbowski","year":"2007","journal-title":"J Cell Biol"},{"issue":"10","key":"ppat.1014665.ref041","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1128\/JVI.03226-13","article-title":"An important role for mitochondrial antiviral signaling protein in the Kaposi\u2019s sarcoma-associated herpesvirus life cycle","volume":"88","author":"JA West","year":"2014","journal-title":"J Virol"},{"issue":"7213","key":"ppat.1014665.ref042","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"H Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ppat.1014665.ref043","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.immuni.2008.09.003","article-title":"The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation","volume":"29","author":"B Zhong","year":"2008","journal-title":"Immunity"},{"key":"ppat.1014665.ref044","doi-asserted-by":"crossref","first-page":"15178","DOI":"10.1038\/ncomms15178","article-title":"Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens","volume":"8","author":"DW Morgens","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"ppat.1014665.ref045","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41418-022-01080-2","article-title":"MARCH5 regulates mitotic apoptosis through MCL1-dependent and independent mechanisms","volume":"30","author":"Y Wang","year":"2023","journal-title":"Cell Death Differ"},{"issue":"4","key":"ppat.1014665.ref046","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI30945","article-title":"Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas","volume":"117","author":"G Sarek","year":"2007","journal-title":"J Clin Invest"},{"issue":"3","key":"ppat.1014665.ref047","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nm0397-293","article-title":"Kaposi\u2019s sarcoma-associated herpesvirus encodes a functional bcl-2 homologue","volume":"3","author":"R Sarid","year":"1997","journal-title":"Nat Med"},{"issue":"4","key":"ppat.1014665.ref048","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/v14040738","article-title":"Structural insight into KsBcl-2 mediated apoptosis inhibition by Kaposi sarcoma associated herpes virus","volume":"14","author":"CD Suraweera","year":"2022","journal-title":"Viruses"},{"issue":"3","key":"ppat.1014665.ref049","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/sj.cdd.4402292","article-title":"BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2","volume":"15","author":"AM Flanagan","year":"2008","journal-title":"Cell Death Differ"},{"issue":"1","key":"ppat.1014665.ref050","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202103156","article-title":"Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy","volume":"221","author":"J Zheng","year":"2022","journal-title":"J Cell Biol"},{"key":"ppat.1014665.ref051","article-title":"Outer mitochondrial membrane E3 Ub ligase MARCH5 controls mitochondrial steps in peroxisome biogenesis","author":"N Verhoeven","year":"2023","journal-title":"bioRxiv"},{"issue":"3","key":"ppat.1014665.ref052","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006256","article-title":"Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism","volume":"13","author":"ZE Sychev","year":"2017","journal-title":"PLoS Pathog"},{"issue":"29","key":"ppat.1014665.ref053","doi-asserted-by":"crossref","first-page":"13069","DOI":"10.1073\/pnas.1002985107","article-title":"Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma","volume":"107","author":"KA Sarosiek","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"21","key":"ppat.1014665.ref054","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1158\/1078-0432.CCR-24-0028","article-title":"A phase 1 first-in-human study of the MCL-1 inhibitor AZD5991 in patients with relapsed\/refractory hematologic malignancies","volume":"30","author":"P Desai","year":"2024","journal-title":"Clin Cancer Res"},{"issue":"1","key":"ppat.1014665.ref055","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s43856-023-00380-z","article-title":"Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients","volume":"3","author":"J Yuda","year":"2023","journal-title":"Commun Med (Lond)"},{"issue":"6","key":"ppat.1014665.ref056","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/135965350501000609","article-title":"Prostratin and bortezomib are novel inducers of latent Kaposi\u2019s sarcoma-associated herpesvirus","volume":"10","author":"HJ Brown","year":"2005","journal-title":"Antivir Ther"},{"issue":"19","key":"ppat.1014665.ref057","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1182\/blood-2008-09-178186","article-title":"Patterns of microRNA expression characterize stages of human B-cell differentiation","volume":"113","author":"J Zhang","year":"2009","journal-title":"Blood"},{"issue":"5","key":"ppat.1014665.ref058","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41418-023-01133-0","article-title":"CRISPR screens identify novel regulators of cFLIP dependency and ligand-independent, TRAIL-R1-mediated cell death","volume":"30","author":"N Kuehnle","year":"2023","journal-title":"Cell Death Differ"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1014665","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:54:27Z","timestamp":1791482067000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014665"}},"subtitle":[],"editor":[{"given":"Michael","family":"Lagunoff","sequence":"first","affiliation":[{"name":"University of Washington","place":["UNITED STATES OF AMERICA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1014665","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}