{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:59Z","timestamp":1791571859479,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014666","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000}}],"reference-count":127,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI171568"],"award-info":[{"award-number":["AI171568"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["153325"],"award-info":[{"award-number":["153325"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["168550"],"award-info":[{"award-number":["168550"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["180737"],"award-info":[{"award-number":["180737"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Systemic lupus erythematosus (SLE) is characterized by autoantibody production alongside inflammatory manifestations, including nephritis. In SLE, infections are frequent and associated with disease flares, increasing morbidity and mortality. Additionally, dysbiosis, often marked by overgrowth of Pseudomonadota, is a prominent feature of SLE and lupus nephritis. We previously demonstrated that complexes of DNA and curli, an amyloidogenic protein from biofilms of Pseudomonadota, including\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhimurium and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , can induce anti-dsDNA and anti-chromatin autoantibody responses. Here, we assessed the effects of curli administration or\n                    <jats:italic>Salmonella<\/jats:italic>\n                    infection on autoimmune manifestations in wild-type and lupus-prone mice. A multiplex autoantibody assay showed increased levels of anti-C1q antibodies in curli-treated C57BL\/6 and lupus-prone NZBxW\/F1 mice compared to PBS-treated controls. An anti-C1q-specific ELISA confirmed the presence of anti-C1q antibodies in C57BL\/6 mice after treatment with curli\/DNA, extracted from\n                    <jats:italic>E. coli<\/jats:italic>\n                    or\n                    <jats:italic>Salmonella<\/jats:italic>\n                    biofilms, or infection with\n                    <jats:italic>Salmonella<\/jats:italic>\n                    . Prior to the onset of spontaneous disease, sera from young NZBxW\/F1 mice, injected with curli, demonstrated increased anti-dsDNA and anti-C1q antibody responses compared to PBS-treated controls; however, no differences were found in older mice, post-onset, when autoantibody levels were already high. In MRL\/lpr mice, curli treatment significantly exacerbated anti-C1q antibody production regardless of age and disease stage, compared to PBS-treated controls. While curli treatment did not significantly affect proteinuria in either model, curli-treatment of MRL\/lpr mice significantly increased C1q deposition in glomeruli. This study uncovers a novel mechanism for the induction of anti-C1q autoantibodies and how infection or dysbiosis may exacerbate renal disease in SLE.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014666","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:46:01Z","timestamp":1790876761000},"page":"e1014666","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salmonella infection and biofilms drive anti-C1q and anti-dsDNA autoantibodies in systemic autoimmunity"],"prefix":"10.1371","volume":"22","author":[{"given":"Kaitlyn","family":"Grando","sequence":"first","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Elkins","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Nicastro","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Bessho","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Olubajo","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Kowal","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Tam","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Caricchio","sequence":"additional","affiliation":[{"name":"UMass Chan Medical School","place":["Worcester, Massachusetts, United States of America"],"department":["Division of Rheumatology, Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pisetsky","sequence":"additional","affiliation":[{"name":"Durham VA Medical Center and Duke University Medical Center","place":["Durham, North Carolina, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg J.","family":"Silverman","sequence":"additional","affiliation":[{"name":"NYU Grossman School of Medicine","place":["New York, New York, United States of America"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-0226","authenticated-orcid":true,"given":"\u00c7agla","family":"T\u00fckel","sequence":"additional","affiliation":[{"name":"Center for Microbiology and Immunology, Temple University Lewis Katz School of Medicine","place":["Philadelphia, Pennsylvania, United States of America"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"7","key":"ppat.1014666.ref001","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.it.2018.04.003","article-title":"Divergent roles of antiself antibodies during infection","volume":"39","author":"J Rivera-Correa","year":"2018","journal-title":"Trends Immunol"},{"key":"ppat.1014666.ref002","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1196\/annals.1422.061","article-title":"Autoantibodies in nonautoimmune individuals during 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