{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:45:19Z","timestamp":1791917119287,"version":"4.3.4"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014675","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFD1800102"],"award-info":[{"award-number":["2022YFD1800102"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32422087"],"award-info":[{"award-number":["32422087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202773"],"award-info":[{"award-number":["32202773"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Program of Chinese Academy of Agricultural Sciences","award":["CAAS-CSLPDCP-202401"],"award-info":[{"award-number":["CAAS-CSLPDCP-202401"]}],"id":[{"id":"https:\/\/ror.org\/0313jb750","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Rabies is an almost always fatal disease caused by rabies virus (RABV). Once RABV enters the central nervous system, the mortality rate is almost 100%. Therefore, preventing RABV from entering the nervous system is crucial for the development of anti-RABV therapeutics. Here, we found that the L-type calcium channel Cav1.2 pore-forming subunit (Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2) and potassium calcium-activated channel subfamily M alpha 1 (KCa1.1) are involved in the internalization of RABV using an siRNA approach. RABV glycoprotein interacts with Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2, a process that is required for the subsequent activation of the channel. The activated Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 then interacts with and activates KCa1.1 to regulate the endocytosis of RABV by promoting the F-actin polymerization. Importantly, diltiazem, a blocker of Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 and an FDA-approved drug, has been shown to substantially reduce mortality in mice infected with RABV. Approximately 70% of mice survived following treatment with diltiazem at 50 mg\/kg, whereas the 25 mg\/kg dose resulted in 26% survival. Our findings suggest that Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 is a promising target for the development of antiviral drugs against rabies and enhances our comprehension of the RABV entry mechanism.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014675","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:49:31Z","timestamp":1791308971000},"page":"e1014675","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the Cav1.2-KCa1.1 axis prevents rabies virus internalization and protects against lethal infection"],"prefix":"10.1371","volume":"22","author":[{"given":"Ziruo","family":"Sun","sequence":"first","affiliation":[{"name":"Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences","place":["Harbin, People\u2019s Republic of China"],"department":["State Key Laboratory of Animal Disease 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