{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:38:29Z","timestamp":1792694309725,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.ppat.1014686","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000}}],"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871285"],"award-info":[{"award-number":["31871285"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170304"],"award-info":[{"award-number":["32170304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Science and Technology Plan Project","award":["2023B1212060046"],"award-info":[{"award-number":["2023B1212060046"]}]}],"content-domain":{"domain":["www.plospathogens.org"],"crossmark-restriction":false},"short-container-title":["PLoS Pathog"],"abstract":"<jats:p>\n                    Plant DNA viruses, such as\n                    <jats:italic>Cauliflower mosaic virus<\/jats:italic>\n                    (CaMV) and\n                    <jats:italic>Cabbage leaf curl virus<\/jats:italic>\n                    (CaLCuV), are devastating pathogens that cause substantial yield losses in crops worldwide. These viruses assemble their genomes into minichromosomes with host histones. Histone post-translational modifications (PTMs) are important for viral replication and host resistance. In this study, we demonstrate that the CaMV pathogenicity factor P6 interacts with Arabidopsis deubiquitinases UBP12 and UBP13, which are typically negative regulators of plant immunity. Using affinity purification\u2013mass spectrometry (AP-MS), we identified UBP12\/13 as prominent P6 interactors and confirmed their nuclear association. CaMV infection and P6 overexpression increased UBP12 abundance, suggesting the latter promotes viral infection. By contrast,\n                    <jats:italic>ubp12\/13<\/jats:italic>\n                    mutants exhibited enhanced resistance, characterized by reduced accumulation of viral DNA and transcripts. Chromatin immunoprecipitation (ChIP)-qPCR showed that the monoubiquitinated H2A (H2Aub) and H3K27me3 modifications on the CaMV 35S promoter, but not the 19S promoter, were significantly elevated in\n                    <jats:italic>ubp12\/13<\/jats:italic>\n                    mutants compared with wild-type plants. Furthermore, UBP12\/13 are also targeted by AC2, a transcriptional activator from CaLCuV, indicating a conserved strategy among plant DNA viruses. Our findings support a working model in which viral pathogenicity factors hijack UBP12\/13, which in turn may alter H2Aub homeostasis on viral minichromosomes to relieve epigenetic silencing and promote infection. Together, these findings point to a previously unrecognized route by which plant DNA viruses may influence host chromatin-associated pathways and identify UBP12\/13 as potential targets for engineering virus-resistant crops.\n                  <\/jats:p>","DOI":"10.1371\/journal.ppat.1014686","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:47:51Z","timestamp":1792086471000},"page":"e1014686","update-policy":"https:\/\/doi.org\/10.1371\/journal.ppat.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["The pathogenicity factor of DNA virus interacts with Arabidopsis deubiquitinases UBP12\/13 to promote viral infection"],"prefix":"10.1371","volume":"22","author":[{"given":"Shun","family":"Li","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences","place":["Guangzhou, China"]},{"name":"Plant Protection Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Green Prevention and Control on Fruits and Vegetables in South China Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of High Technology for Plant Protection","place":["Guangzhou, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqin","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences","place":["Guangzhou, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory","place":["Singapore, Singapore"]},{"name":"School of Applied Science, Republic Polytechnic","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hai","family":"Chua","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-3415","authenticated-orcid":true,"given":"Shulin","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany & Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences","place":["Guangzhou, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Temasek Life Sciences Laboratory","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"2","key":"ppat.1014686.ref001","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0092-8674(82)90156-8","article-title":"A transcriptionally active, covalently closed minichromosome of cauliflower mosaic virus DNA isolated from infected turnip leaves","volume":"29","author":"N Olszewski","year":"1982","journal-title":"Cell"},{"issue":"20","key":"ppat.1014686.ref002","doi-asserted-by":"crossref","first-page":"10808","DOI":"10.1128\/JVI.77.20.10808-10818.2003","article-title":"Mapping of abutilon mosaic geminivirus minichromosomes","volume":"77","author":"M Pilartz","year":"2003","journal-title":"J Virol"},{"issue":"8","key":"ppat.1014686.ref003","article-title":"The replication initiator protein of a geminivirus interacts with host monoubiquitination machinery and stimulates transcription of the viral genome","volume":"13","author":"Mansi","year":"2017","journal-title":"PLoS Pathog"},{"issue":"10","key":"ppat.1014686.ref004","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1099\/jgv.0.001497","article-title":"ICTV virus taxonomy profile: Caulimoviridae","volume":"101","author":"PY Teycheney","year":"2020","journal-title":"J Gen Virol"},{"issue":"6","key":"ppat.1014686.ref005","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1364-3703.2002.00136.x","article-title":"Cauliflower mosaic virus: Still in the news","volume":"3","author":"M Haas","year":"2002","journal-title":"Mol Plant Pathol"},{"issue":"6","key":"ppat.1014686.ref006","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0092-8674(89)90769-1","article-title":"Posttranscriptional trans-activation in cauliflower mosaic virus","volume":"59","author":"JM Bonneville","year":"1989","journal-title":"Cell"},{"issue":"2","key":"ppat.1014686.ref007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0042-6822(81)90349-4","article-title":"Transcription of cauliflower mosaic virus DNA. Detection of transcripts, properties, and location of the gene encoding the virus inclusion body protein","volume":"111","author":"SN Covey","year":"1981","journal-title":"Virology"},{"issue":"2","key":"ppat.1014686.ref008","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0042-6822(80)90057-4","article-title":"Polypeptides associated with inclusion bodies from leaves of turnip infected with cauliflower mosaic virus","volume":"105","author":"MW Shockey","year":"1980","journal-title":"Virology"},{"issue":"6","key":"ppat.1014686.ref009","first-page":"537","article-title":"Expression of disease symptoms in cauliflower mosaic virus genomic hybrids","volume":"2","author":"SD Daubert","year":"1984","journal-title":"J Mol Appl Genet"},{"key":"ppat.1014686.ref010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.virol.2014.11.017","article-title":"Mutations within A 35 amino acid region of P6 influence self-association, inclusion body formation, and Caulimovirus infectivity","volume":"476","author":"L Lutz","year":"2015","journal-title":"Virology"},{"issue":"11","key":"ppat.1014686.ref011","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1094\/MPMI.2000.13.11.1275","article-title":"Agroinfiltration of Cauliflower mosaic virus gene VI elicits hypersensitive response in Nicotiana species","volume":"13","author":"K Palanichelvam","year":"2000","journal-title":"Mol Plant Microbe Interact"},{"issue":"10","key":"ppat.1014686.ref012","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1094\/MPMI.1999.12.10.919","article-title":"Systemic cell death is elicited by the interaction of a single gene in Nicotiana clevelandii and Gene VI of cauliflower mosaic virus","volume":"12","author":"L Kir\u00e1ly","year":"1999","journal-title":"Mol Plant Microbe Interact"},{"issue":"15","key":"ppat.1014686.ref013","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1038\/emboj.2008.129","article-title":"Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4","volume":"27","author":"G Haas","year":"2008","journal-title":"EMBO J"},{"issue":"3","key":"ppat.1014686.ref014","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1105\/tpc.104.029017","article-title":"The open reading frame VI product of Cauliflower mosaic virus is a nucleocytoplasmic protein: its N terminus mediates its nuclear export and formation of electron-dense viroplasms","volume":"17","author":"M Haas","year":"2005","journal-title":"Plant Cell"},{"key":"ppat.1014686.ref015","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1099\/vir.0.83090-0","article-title":"Cauliflower mosaic virus protein P6 is a suppressor of RNA silencing","volume":"88","author":"AJ Love","year":"2007","journal-title":"J Gen Virol"},{"issue":"18","key":"ppat.1014686.ref016","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1093\/nar\/gkn590","article-title":"The CaMV transactivator\/viroplasmin interferes with RDR6-dependent trans-acting and secondary siRNA pathways in Arabidopsis","volume":"36","author":"PV Shivaprasad","year":"2008","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"ppat.1014686.ref017","doi-asserted-by":"crossref","first-page":"8997","DOI":"10.1128\/JVI.00719-08","article-title":"Viral genome methylation as an epigenetic defense against geminiviruses","volume":"82","author":"P Raja","year":"2008","journal-title":"J Virol"},{"key":"ppat.1014686.ref018","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fpls.2014.00056","article-title":"Deubiquitylating enzymes and their emerging role in plant biology","volume":"5","author":"E Isono","year":"2014","journal-title":"Front Plant Sci"},{"issue":"45","key":"ppat.1014686.ref019","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103633118","article-title":"Ubiquitin-specific proteases UBP12 and UBP13 promote shade avoidance response by enhancing PIF7 stability","volume":"118","author":"Y Zhou","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ppat.1014686.ref020","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1111\/nph.15879","article-title":"Arabidopsis ubiquitin-specific proteases UBP12 and UBP13 shape ORE1 levels during leaf senescence induced by nitrogen deficiency","volume":"223","author":"S-H Park","year":"2019","journal-title":"New Phytol"},{"issue":"5","key":"ppat.1014686.ref021","doi-asserted-by":"crossref","first-page":"100348","DOI":"10.1016\/j.xplc.2022.100348","article-title":"Deubiquitination of BES1 by UBP12\/UBP13 promotes brassinosteroid signaling and plant growth","volume":"3","author":"S-H Park","year":"2022","journal-title":"Plant Commun"},{"issue":"3","key":"ppat.1014686.ref022","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/jxb\/erad429","article-title":"Decoding plant adaptation: deubiquitinating enzymes UBP12 and UBP13 in hormone signaling, light response, and developmental processes","volume":"75","author":"H Feng","year":"2024","journal-title":"J Exp Bot"},{"issue":"2","key":"ppat.1014686.ref023","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/nph.19639","article-title":"Insights into a functional model of key deubiquitinases UBP12\/13 in plants","volume":"242","author":"S Zhang","year":"2024","journal-title":"New Phytol"},{"issue":"1","key":"ppat.1014686.ref024","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.molp.2022.11.008","article-title":"UBP12\/UBP13-mediated deubiquitination of salicylic acid receptor NPR3 suppresses plant immunity","volume":"16","author":"Y Zhou","year":"2023","journal-title":"Mol Plant"},{"issue":"2","key":"ppat.1014686.ref025","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0042-6822(92)90610-2","article-title":"Abutilon mosaic geminivirus double-stranded DNA is packed into minichromosomes","volume":"189","author":"M Pilartz","year":"1992","journal-title":"Virology"},{"key":"ppat.1014686.ref026","doi-asserted-by":"crossref","first-page":"16126","DOI":"10.1038\/nplants.2016.126","article-title":"H2A deubiquitinases UBP12\/13 are part of the Arabidopsis polycomb group protein system","volume":"2","author":"M Derkacheva","year":"2016","journal-title":"Nat Plants"},{"issue":"1","key":"ppat.1014686.ref027","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s13059-020-02062-8","article-title":"Removal of H2Aub1 by ubiquitin-specific proteases 12 and 13 is required for stable Polycomb-mediated gene repression in Arabidopsis","volume":"21","author":"LEM Kralemann","year":"2020","journal-title":"Genome Biol"},{"issue":"4","key":"ppat.1014686.ref028","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1104\/pp.124.4.1828","article-title":"The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine","volume":"124","author":"N Yan","year":"2000","journal-title":"Plant Physiol"},{"issue":"2","key":"ppat.1014686.ref029","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1104\/pp.112.213009","article-title":"Ubiquitin-specific proteases UBP12 and UBP13 act in circadian clock and photoperiodic flowering regulation in Arabidopsis","volume":"162","author":"X Cui","year":"2013","journal-title":"Plant Physiol"},{"issue":"5","key":"ppat.1014686.ref030","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1073\/pnas.1714177115","article-title":"Regulation of the stability of RGF1 receptor by the ubiquitin-specific proteases UBP12\/UBP13 is critical for root meristem maintenance","volume":"115","author":"Z An","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"ppat.1014686.ref031","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/j.1460-2075.1983.tb01547.x","article-title":"Electron microscopic studies of the different topological forms of the cauliflower mosaic virus DNA: Knotted encapsidated DNA and nuclear minichromosome","volume":"2","author":"J M\u00e9nissier","year":"1983","journal-title":"EMBO J"},{"issue":"10","key":"ppat.1014686.ref032","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1128\/JVI.01771-08","article-title":"Geminivirus AL2 and L2 proteins suppress transcriptional gene silencing and cause genome-wide reductions in cytosine methylation","volume":"83","author":"RC Buchmann","year":"2009","journal-title":"J Virol"},{"issue":"6","key":"ppat.1014686.ref033","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1128\/JVI.02625-14","article-title":"Analysis of geminivirus AL2 and L2 proteins reveals a novel AL2 silencing suppressor activity","volume":"89","author":"JN Jackel","year":"2015","journal-title":"J Virol"},{"issue":"1","key":"ppat.1014686.ref034","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.virol.2008.03.012","article-title":"Functional analysis of bipartite begomovirus coat protein promoter sequences","volume":"376","author":"G Lacatus","year":"2008","journal-title":"Virology"},{"issue":"2","key":"ppat.1014686.ref035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.virol.2009.07.004","article-title":"The Arabidopsis PEAPOD2 transcription factor interacts with geminivirus AL2 protein and the coat protein promoter","volume":"392","author":"G Lacatus","year":"2009","journal-title":"Virology"},{"issue":"3","key":"ppat.1014686.ref036","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/jipb.13580","article-title":"Plant virology in the 21st century in China: Recent advances and future directions","volume":"66","author":"J Wu","year":"2024","journal-title":"J Integr Plant Biol"},{"key":"ppat.1014686.ref037","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06671","article-title":"Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4\/KYP to counter host defense","volume":"4","author":"C Castillo-Gonz\u00e1lez","year":"2015","journal-title":"Elife"},{"issue":"23","key":"ppat.1014686.ref038","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1128\/JVI.01981-12","article-title":"Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression","volume":"86","author":"M Kalamvoki","year":"2012","journal-title":"J Virol"},{"issue":"10","key":"ppat.1014686.ref039","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1042\/BCJ20160304","article-title":"USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein","volume":"474","author":"A Ali","year":"2017","journal-title":"Biochem J"},{"issue":"1","key":"ppat.1014686.ref040","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1104\/pp.108.121038","article-title":"Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection","volume":"148","author":"JT Ascencio-Ib\u00e1\u00f1ez","year":"2008","journal-title":"Plant Physiol"},{"key":"ppat.1014686.ref041","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12870-014-0302-7","article-title":"Altered expression of Arabidopsis genes in response to a multifunctional geminivirus pathogenicity protein","volume":"14","author":"L Liu","year":"2014","journal-title":"BMC Plant Biol"},{"issue":"7","key":"ppat.1014686.ref042","article-title":"TOR is a negative regulator of autophagy in Arabidopsis thaliana","volume":"5","author":"Y Liu","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"ppat.1014686.ref043","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/nph.13967","article-title":"Viral protein suppresses oxidative burst and salicylic acid-dependent autophagy and facilitates bacterial growth on virus-infected plants","volume":"211","author":"AS Zvereva","year":"2016","journal-title":"New Phytol"},{"issue":"3","key":"ppat.1014686.ref044","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41477-019-0378-z","article-title":"Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase","volume":"5","author":"J Van Leene","year":"2019","journal-title":"Nat Plants"},{"issue":"1","key":"ppat.1014686.ref045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1469-8137.2011.03672.x","article-title":"Deubiquitinating enzymes AtUBP12 and AtUBP13 and their tobacco homologue NtUBP12 are negative regulators of plant immunity","volume":"191","author":"R Ewan","year":"2011","journal-title":"New Phytol"},{"issue":"2","key":"ppat.1014686.ref046","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1104\/pp.105.066803","article-title":"Cauliflower mosaic virus, a compatible pathogen of Arabidopsis, engages three distinct defense-signaling pathways and activates rapid systemic generation of reactive oxygen species","volume":"139","author":"AJ Love","year":"2005","journal-title":"Plant Physiol"},{"issue":"1","key":"ppat.1014686.ref047","first-page":"69","article-title":"Turnip aphids (Lipaphis erysimi) discriminate host plants based on the strain of Cauliflower mosaic virus infection","volume":"31","author":"A M","year":"2019","journal-title":"Emir J Food Agric"},{"issue":"18","key":"ppat.1014686.ref048","doi-asserted-by":"crossref","first-page":"9457","DOI":"10.1128\/JVI.76.18.9457-9464.2002","article-title":"The cauliflower mosaic virus virion-associated protein is dispensable for viral replication in single cells","volume":"76","author":"K Kobayashi","year":"2002","journal-title":"J Virol"},{"key":"ppat.1014686.ref049","article-title":"Use of potato virus X (PVX)-based vectors for gene expression and virus-induced gene silencing (VIGS)","author":"C Lacomme","year":"2008","journal-title":"Curr Protoc Microbiol"},{"issue":"3","key":"ppat.1014686.ref050","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/nph.16397","article-title":"Natural variation in the Arabidopsis AGO2 gene is associated with susceptibility to potato virus X","volume":"226","author":"C Brosseau","year":"2020","journal-title":"New Phytol"},{"issue":"3","key":"ppat.1014686.ref051","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nmeth0305-213","article-title":"Profiling histone modification patterns in plants using genomic tiling microarrays","volume":"2","author":"A-V Gendrel","year":"2005","journal-title":"Nat Methods"},{"key":"ppat.1014686.ref052","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1038\/ncomms5601","article-title":"Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis","volume":"5","author":"X Hou","year":"2014","journal-title":"Nat Commun"},{"issue":"9","key":"ppat.1014686.ref053","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3390\/cells10092278","article-title":"Cauliflower mosaic virus P6 dysfunctions histone deacetylase HD2C to promote virus infection","volume":"10","author":"S Li","year":"2021","journal-title":"Cells"}],"updated-by":[{"DOI":"10.1371\/journal.ppat.1014686","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000}}],"container-title":["PLOS Pathogens"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:44:32Z","timestamp":1792691072000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.ppat.1014686"}},"subtitle":[],"editor":[{"given":"Aiming","family":"Wang","sequence":"first","affiliation":[{"name":"Agriculture and Agri-Food Canada","place":["CANADA"]}],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":53,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.ppat.1014686","relation":{},"ISSN":["1553-7374"],"issn-type":[{"value":"1553-7374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,15]]}}}