{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:50:05Z","timestamp":1776790205114,"version":"3.51.2"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T00:00:00Z","timestamp":1332201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0033037","type":"journal-article","created":{"date-parts":[[2012,3,22]],"date-time":"2012-03-22T10:55:46Z","timestamp":1332413746000},"page":"e33037","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":91,"title":["Breast Cancer Exosome-like Microvesicles and Salivary Gland Cells Interplay Alters Salivary Gland Cell-Derived Exosome-like Microvesicles In Vitro"],"prefix":"10.1371","volume":"7","author":[{"given":"Chang S.","family":"Lau","sequence":"first","affiliation":[]},{"given":"David T. W.","family":"Wong","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,3,20]]},"reference":[{"key":"ref1","first-page":"467","article-title":"Oral cancer proteomics.","volume":"9","author":"S Hu","year":"2007","journal-title":"Current opinion in molecular therapeutics"},{"key":"ref2","article-title":"Preclinical validation of salivary biomarkers for primary Sjogren&apos;s syndrome.","author":"S Hu","year":"2010","journal-title":"Arthritis Care Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0015573","article-title":"Salivary Transcriptomic and Proteomic Biomarkers for Breast Cancer Detection.","volume":"5","author":"L Zhang","year":"2010","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1053\/j.gastro.2009.11.010","article-title":"Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer.","volume":"138","author":"L Zhang","year":"2010","journal-title":"Gastroenterology"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/intimm\/dxh267","article-title":"Exosomal-like vesicles are present in human blood plasma.","volume":"17","author":"M Caby","year":"2005","journal-title":"Int Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-9-9","article-title":"Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages.","volume":"9","author":"C Lasser","year":"2011","journal-title":"J Transl Med"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0008577","article-title":"Nanostructural and transcriptomic analyses of human saliva derived exosomes.","volume":"5","author":"V Palanisamy","year":"2010","journal-title":"PLoS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ki.2008.206","article-title":"Urinary exosomal transcription factors, a new class of biomarkers for renal disease.","volume":"74","author":"H Zhou","year":"2008","journal-title":"Kidney Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: Extracellular organelles important in intercellular communication.","volume":"73","author":"S Mathivanan","year":"2010","journal-title":"Journal of Proteomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/jcp.1041470105","article-title":"Exosome formation during maturation of mammalian and avian reticulocytes: evidence that exosome release is a major route for externalization of obsolete membrane proteins.","volume":"147","author":"R Johnstone","year":"1991","journal-title":"J Cell Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes.","volume":"29","author":"K Trajkovic","year":"2008","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcmd.2005.12.001","article-title":"Exosomes biological significance: A concise review.","volume":"36","author":"R Johnstone","year":"2006","journal-title":"Blood Cells, Molecules, and Diseases"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses.","volume":"9","author":"C Th\u00e9ry","year":"2009","journal-title":"Nature Reviews Immunology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes.","volume":"4","author":"L Zitvogel","year":"1998","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.4049\/jimmunol.172.4.2126","article-title":"Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I\/peptide complexes to dendritic cells.","volume":"172","author":"F Andre","year":"2004","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1158\/0008-5472.CAN-10-3248","article-title":"An Ex(o)citing Machinery for Invasive Tumor Growth.","volume":"70","author":"A Hendrix","year":"2010","journal-title":"Cancer Research"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1021\/pr800658c","article-title":"Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).","volume":"8","author":"M Gonzales-Begne","year":"2009","journal-title":"Journal of Proteome Research"},{"key":"ref18","first-page":"3118","article-title":"Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro.","author":"BR Brinkley","year":"1980","journal-title":"Cancer Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/1097-0142(19810801)48:3<745::AID-CNCR2820480314>3.0.CO;2-7","article-title":"A neoplastic epithelial duct cell line established from an irradiated human salivary gland.","author":"SM Shirasuna K","year":"1981","journal-title":"Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jim.2009.03.008","article-title":"A new flow cytometric assay for the simultaneous analysis of antigen-specific elimination of T cells in heterogenous T cell populations.","volume":"344","author":"FK Schutz","year":"2009","journal-title":"Journal of Immunological Methods"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1096\/fasebj.11.6.9194523","article-title":"The tetraspanin superfamily: molecular facilitators.","volume":"11","author":"H Maecker","year":"1997","journal-title":"FASEB J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10911-006-9031-3","article-title":"Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland.","volume":"11","author":"J McManaman","year":"2006","journal-title":"J Mammary Gland Bio Neoplasia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.","volume":"9","author":"H Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0854.2004.00246.x","article-title":"A protein&apos;s final ESCRT.","volume":"6","author":"M Babst","year":"2005","journal-title":"Traffic"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvj128","article-title":"Exosomes: A common pathway for a specialized function.","volume":"140","author":"G van Niel","year":"2006","journal-title":"J Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1471-2407-11-108","article-title":"Interaction and uptake of exosomes by ovarian cancer cells.","volume":"11","author":"C Escrevente","year":"2011","journal-title":"BMC Canc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1182\/blood-2007-03-078709","article-title":"Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA.","volume":"110","author":"CV Deregibus","year":"2007","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0033037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T18:22:06Z","timestamp":1561486926000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0033037"}},"subtitle":[],"editor":[{"given":"Jianming","family":"Qiu","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,3,20]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0033037","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,20]]}}}