{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:14:13Z","timestamp":1771881253051,"version":"3.50.1"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0042321","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T10:09:58Z","timestamp":1343470198000},"page":"e42321","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["XMRV Induces Cell Migration, Cytokine Expression and Tumor Angiogenesis: Are 22Rv1 Cells a Suitable Prostate Cancer Model?"],"prefix":"10.1371","volume":"7","author":[{"given":"Kristin","family":"Stieler","sequence":"first","affiliation":[]},{"given":"Udo","family":"Schumacher","sequence":"additional","affiliation":[]},{"given":"Andrea Kristina","family":"Horst","sequence":"additional","affiliation":[]},{"given":"Nicole","family":"Fischer","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/erc.1.00795","article-title":"Primary cell cultures as models of prostate cancer development.","volume":"12","author":"DM Peehl","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"ref2","first-page":"115","article-title":"The LNCaP cell line\u2013a new model for studies on human prostatic carcinoma.","volume":"37","author":"JS Horoszewicz","year":"1980","journal-title":"Prog Clin Biol Res"},{"key":"ref3","first-page":"16","article-title":"Establishment and characterization of a human prostatic carcinoma cell line (PC-3).","volume":"17","author":"ME Kaighn","year":"1979","journal-title":"Invest Urol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/ijc.2910210305","article-title":"Isolation of a human prostate carcinoma cell line (DU 145).","volume":"21","author":"KR Stone","year":"1978","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s11626-999-0115-4","article-title":"A new human prostate carcinoma cell line, 22Rv1.","volume":"35","year":"1999","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1128\/JVI.00546-09","article-title":"Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.","volume":"83","author":"EC Knouf","year":"2009","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.1205292","article-title":"Recombinant origin of the retrovirus XMRV.","volume":"333","author":"T Paprotka","year":"2011","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1371\/journal.ppat.0020025","article-title":"Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.","volume":"2","author":"A Urisman","year":"2006","journal-title":"PLoS Pathog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"16351","DOI":"10.1073\/pnas.0906922106","article-title":"XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors.","volume":"106","author":"R Schlaberg","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10028","DOI":"10.1158\/0008-5472.CAN-10-2837","article-title":"XMRV: a new virus in prostate cancer?","volume":"70","author":"AL Aloia","year":"2010","journal-title":"Cancer Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nrurol.2011.101","article-title":"Prostate cancer: XMRV\u2013contaminant, not cause?","volume":"8","author":"SJ Farley","year":"2011","journal-title":"Nat Rev Urol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jcv.2008.04.016","article-title":"Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer.","volume":"43","author":"N Fischer","year":"2008","journal-title":"J Clin Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1742-4690-8-13","article-title":"Analysis of XMRV integration sites from human prostate cancer tissues suggests PCR contamination rather than genuine human infection.","volume":"8","author":"JA Garson","year":"2011","journal-title":"Retrovirology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1742-4690-6-92","article-title":"Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients.","volume":"6","author":"O Hohn","year":"2009","journal-title":"Retrovirology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/bmb\/ldr010","article-title":"XMRV, prostate cancer and chronic fatigue syndrome.","volume":"98","author":"JC Kenyon","year":"2011","journal-title":"Br Med Bull"},{"key":"ref16","article-title":"Next generation sequencing of prostate tumours provides independent evidence of XMRV contamination.","author":"F Mo","year":"2011"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4690-8-23","article-title":"No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.","volume":"8","author":"T Sakuma","year":"2011","journal-title":"Retrovirology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e25592","DOI":"10.1371\/journal.pone.0025592","article-title":"No detection of XMRV in blood samples and tissue sections from prostate cancer patients in Northern Europe.","volume":"6","author":"K Stieler","year":"2011","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/pros.21255","article-title":"Prevalence of human xenotropic murine leukemia virus-related gammaretrovirus (XMRV) in Dutch prostate cancer patients.","volume":"71","author":"GW Verhaegh","year":"2011","journal-title":"Prostate"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1742-4690-7-111","article-title":"Disease-associated XMRV sequences are consistent with laboratory contamination.","volume":"7","author":"S Hue","year":"2010","journal-title":"Retrovirology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11010-010-0426-5","article-title":"Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1.","volume":"340","author":"T Liu","year":"2010","journal-title":"Mol Cell Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/humu.21138","article-title":"Identification of novel truncated androgen receptor (AR) mutants including unreported pre-mRNA splicing variants in the 22Rv1 hormone-refractory prostate cancer (PCa) cell line.","volume":"31","author":"G Marcias","year":"2010","journal-title":"Hum Mutat"},{"key":"ref23","first-page":"831","article-title":"Estrogen in combination with 5-azacitidine up-regulates p75NTR expression and induces apoptosis in 22Rv1 prostate cancer cells.","volume":"2","author":"JD Yu","year":"2009","journal-title":"Mol Med Report"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1742-4690-7-101","article-title":"The mouse \u201cxenotropic\u201d gammaretroviruses and their XPR1 receptor.","volume":"7","author":"CA Kozak","year":"2010","journal-title":"Retrovirology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"10550","DOI":"10.1128\/JVI.00933-07","article-title":"Wild mouse variants of envelope genes of xenotropic\/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry.","volume":"81","author":"Y Yan","year":"2007","journal-title":"J Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.18632\/oncotarget.287","article-title":"Xenotropic murine leukemia virus-related virus (XMRV) in prostate cancer cells likely represents a laboratory artifact.","volume":"2","author":"J Yang","year":"2011","journal-title":"Oncotarget"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/mt.2008.6","article-title":"A multicolor panel of novel lentiviral \u201cgene ontology\u201d (LeGO) vectors for functional gene analysis.","volume":"16","author":"K Weber","year":"2008","journal-title":"Mol Ther"},{"key":"ref28","first-page":"2912","article-title":"Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.","volume":"8","author":"JA Tuxhorn","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/pros.10327","article-title":"Regulation of rat prostate stromal cell myodifferentiation by androgen and TGF-beta1.","volume":"58","author":"MJ Gerdes","year":"2004","journal-title":"Prostate"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e11738","DOI":"10.1371\/journal.pone.0011738","article-title":"Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.","volume":"5","author":"K Stieler","year":"2010","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.virol.2009.12.028","article-title":"Host range and cellular tropism of the human exogenous gammaretrovirus XMRV.","volume":"399","author":"K Stieler","year":"2010","journal-title":"Virology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e8519","DOI":"10.1371\/journal.pone.0008519","article-title":"Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome.","volume":"5","author":"O Erlwein","year":"2010","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1742-4690-7-10","article-title":"Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome.","volume":"7","author":"HC Groom","year":"2010","journal-title":"Retrovirology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3390\/v3081312","article-title":"Origin of XMRV and its demise as a human pathogen associated with chronic fatigue syndrome.","volume":"3","author":"O Hohn","year":"2011","journal-title":"Viruses"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e15632","DOI":"10.1371\/journal.pone.0015632","article-title":"No evidence for XMRV in German CFS and MS patients with fatigue despite the ability of the virus to infect human blood cells in vitro.","volume":"5","author":"O Hohn","year":"2010","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrurol.2011.225","article-title":"XMRV and prostate cancer\u2013a \u2018final\u2019 perspective.","volume":"9","author":"KS Sfanos","year":"2012","journal-title":"Nat Rev Urol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1016\/S0140-6736(11)60899-4","article-title":"XMRV and CFS\u2013the sad end of a story.","volume":"379","author":"FJ van Kuppeveld","year":"2012","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nature04791","article-title":"Fatality in mice due to oversaturation of cellular microRNA\/short hairpin RNA pathways.","volume":"441","author":"D Grimm","year":"2006","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"7908","DOI":"10.1128\/JVI.00389-10","article-title":"Acutely transforming retrovirus expressing Nras generated from HT-1080 fibrosarcoma cells infected with the human retrovirus XMRV.","volume":"84","author":"MJ Metzger","year":"2010","journal-title":"J Virol"},{"key":"ref40","article-title":"XMRV accelerates cellular proliferation, transformational activity, and invasiveness of prostate cancer cells by downregulating p27(Kip1).","author":"J Pandhare-Dash","year":"2011"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1128\/JVI.06073-11","article-title":"Xpr1 is an atypical G-protein-coupled receptor that mediates xenotropic and polytropic murine retrovirus neurotoxicity.","volume":"86","author":"AE Vaughan","year":"2012","journal-title":"J Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.3390\/v3122442","article-title":"The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus.","volume":"3","author":"JL Cmarik","year":"2011","journal-title":"Viruses"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e3144","DOI":"10.1371\/journal.pone.0003144","article-title":"A natural human retrovirus efficiently complements vectors based on murine leukemia virus.","volume":"3","author":"B Dong","year":"2008","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.2305256","article-title":"Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses.","volume":"247","author":"P Lusso","year":"1990","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0042-6822(02)00074-0","article-title":"Molecular cloning, complete sequence, and biological characterization of a xenotropic murine leukemia virus constitutively released from the human B-lymphoblastoid cell line DG-75.","volume":"308","author":"KP Raisch","year":"2003","journal-title":"Virology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1742-4690-7-110","article-title":"An endogenous murine leukemia viral genome contaminant in a commercial RT-PCR Kit is amplified using standard primers for XMRV.","volume":"7","author":"E Sato","year":"2010","journal-title":"Retrovirology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"12585","DOI":"10.1128\/JVI.01726-08","article-title":"Identification of gammaretroviruses constitutively released from cell lines used for human immunodeficiency virus research.","volume":"82","author":"Y Takeuchi","year":"2008","journal-title":"J Virol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e20874","DOI":"10.1371\/journal.pone.0020874","article-title":"Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines.","volume":"6","author":"KS Sfanos","year":"2011","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.4049\/jimmunol.142.8.2887","article-title":"Expression of retrovirus-related, cytotoxic T lymphocyte- and transplantation-defined antigens in NIH\/3T3 transfectants after a single passage in nude mice.","volume":"142","author":"C Traversari","year":"1989","journal-title":"J Immunol"},{"key":"ref50","first-page":"6021","article-title":"Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model.","volume":"62","author":"JA Tuxhorn","year":"2002","journal-title":"Cancer Res"},{"key":"ref51","first-page":"3298","article-title":"Stromal cells promote angiogenesis and growth of human prostate tumors in a differential reactive stroma (DRS) xenograft model.","volume":"62","author":"JA Tuxhorn","year":"2002","journal-title":"Cancer Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1128\/JVI.63.6.2680-2689.1989","article-title":"Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo.","volume":"63","author":"RA Bosselman","year":"1989","journal-title":"J Virol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0042321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T19:05:16Z","timestamp":1687633516000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0042321"}},"subtitle":[],"editor":[{"given":"Peter","family":"Sommer","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0042321","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}