{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T13:04:04Z","timestamp":1770296644526,"version":"3.49.0"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T00:00:00Z","timestamp":1446768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"DOI":"10.1371\/journal.pbio.1002291","type":"journal-article","created":{"date-parts":[[2015,11,6]],"date-time":"2015-11-06T19:09:35Z","timestamp":1446836975000},"page":"e1002291","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover"],"prefix":"10.1371","volume":"13","author":[{"given":"Dorottya","family":"Kalapis","sequence":"first","affiliation":[]},{"given":"Ana R.","family":"Bezerra","sequence":"additional","affiliation":[]},{"given":"Zolt\u00e1n","family":"Farkas","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Horvath","sequence":"additional","affiliation":[]},{"given":"Zolt\u00e1n","family":"B\u00f3di","sequence":"additional","affiliation":[]},{"given":"Andreea","family":"Daraba","sequence":"additional","affiliation":[]},{"given":"B\u00e9la","family":"Szamecz","sequence":"additional","affiliation":[]},{"given":"Ivo","family":"Gut","sequence":"additional","affiliation":[]},{"given":"M\u00f3nica","family":"Bayes","sequence":"additional","affiliation":[]},{"given":"Manuel A. S.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Csaba","family":"P\u00e1l","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2015,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrg2662","article-title":"The evolutionary consequences of erroneous protein synthesis","volume":"10","author":"D Allan Drummond","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro2472","article-title":"Cellular mechanisms that control mistranslation","volume":"8","author":"NM Reynolds","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1261\/rna.294907","article-title":"The frequency of translational misreading errors in E. coli is largely determined by tRNA competition","volume":"13","author":"EB Kramer","year":"2007","journal-title":"RNA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35008096","article-title":"Rapid degradation of a large fraction of newly synthesized proteins by proteasomes","volume":"404","author":"U Schubert","year":"2000","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1121925","article-title":"Protein Synthesis upon Acute Nutrient Restriction Relies on Proteasome Function","volume":"310","author":"RM Vabulas","year":"2005","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.cell.2008.09.038","article-title":"Mistranslation of Membrane Proteins and Two-Component System Activation Trigger Antibiotic-Mediated Cell Death","volume":"135","author":"MA Kohanski","year":"2008","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R206","DOI":"10.1186\/gb-2007-8-10-r206","article-title":"A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans","volume":"8","author":"AC Gomes","year":"2007","journal-title":"Genome Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.molcel.2010.06.009","article-title":"Hyperaccurate and Error-Prone Ribosomes Exploit Distinct Mechanisms during tRNA Selection","volume":"39","author":"HS Zaher","year":"2010","journal-title":"Mol Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","article-title":"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration","volume":"443","author":"JW Lee","year":"2006","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1741-7007-10-55","article-title":"Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast","volume":"10","author":"JA Paredes","year":"2012","journal-title":"BMC Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/j.1460-2075.1984.tb02176.x","article-title":"Hyper-accurate ribosomes inhibit growth","volume":"3","author":"T Ruusala","year":"1984","journal-title":"EMBO J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nrg3092","article-title":"Error prevention and mitigation as forces in the evolution of genes and genomes","volume":"12","author":"T Warnecke","year":"2011","journal-title":"Nat Rev Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/ncb1478","article-title":"Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state","volume":"8","author":"A Kitamura","year":"2006","journal-title":"Nat Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.molcel.2014.06.017","article-title":"An Inducible Chaperone Adapts Proteasome Assembly to Stress","volume":"55","author":"A Hanssum","year":"2014","journal-title":"Mol Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.celrep.2012.09.036","article-title":"Cellular Strategies for Regulating Functional and Nonfunctional Protein Aggregation","volume":"2","author":"J Gsponer","year":"2012","journal-title":"Cell Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1046\/j.1365-2958.1999.01233.x","article-title":"Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp","volume":"31","author":"MAS Santos","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"14091","DOI":"10.1073\/pnas.1102835108","article-title":"Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen","volume":"108","author":"R Rocha","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/j.1460-2075.1996.tb00886.x","article-title":"Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans","volume":"15","author":"MA Santos","year":"1996","journal-title":"EMBO J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1038\/sj.emboj.7601876","article-title":"Critical roles for a genetic code alteration in the evolution of the genus Candida","volume":"26","author":"RM Silva","year":"2007","journal-title":"EMBO J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/jmbi.1998.1976","article-title":"Missense translation errors in Saccharomyces cerevisiae1","volume":"282","author":"I Stansfield","year":"1998","journal-title":"J Mol Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/yea.931","article-title":"Automated screening in environmental arrays allows analysis of quantitative phenotypic profiles in Saccharomyces cerevisiae","volume":"20","author":"J Warringer","year":"2003","journal-title":"Yeast"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"15724","DOI":"10.1073\/pnas.2435976100","article-title":"High-resolution yeast phenomics resolves different physiological features in the saline response","volume":"100","author":"J Warringer","year":"2003","journal-title":"Proc Natl Acad Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2105-3-35","article-title":"FunSpec: a web-based cluster interpreter for yeast","volume":"3","author":"MD Robinson","year":"2002","journal-title":"BMC Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/sj.emboj.7600553","article-title":"Central role of Ifh1p\u2013Fhl1p interaction in the synthesis of yeast ribosomal proteins","volume":"24","author":"D Rudra","year":"2005","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/1471-2164-9-583","article-title":"Chemical-genetic profile analysis in yeast suggests that a previously uncharacterized open reading frame, YBR261C, affects protein synthesis","volume":"9","author":"M Alamgir","year":"2008","journal-title":"BMC Genomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1128\/MCB.19.8.5247","article-title":"Mutations in Translation Initiation Factors Lead to Increased Rates of Deadenylation and Decapping of mRNAs in Saccharomyces cerevisiae","volume":"19","author":"DC Schwartz","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nature07195","article-title":"Misfolded proteins partition between two distinct quality control compartments","volume":"454","author":"D Kaganovich","year":"2008","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1101\/gad.207407.112","article-title":"Aneuploidy causes proteotoxic stress in yeast","volume":"26","author":"AB Oromendia","year":"2012","journal-title":"Genes Dev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cell.2010.08.038","article-title":"Identification of Aneuploidy-Tolerating Mutations","volume":"143","author":"EM Torres","year":"2010","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1002090","DOI":"10.1371\/journal.pcbi.1002090","article-title":"An Evolutionary Trade-Off between Protein Turnover Rate and Protein Aggregation Favors a Higher Aggregation Propensity in Fast Degrading Proteins","volume":"7","author":"G De Baets","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0092-8674(94)90396-4","article-title":"The ubiquitin-proteasome proteolytic pathway","volume":"79","author":"A Ciechanover","year":"1994","journal-title":"Cell"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/embj.201386822","article-title":"Opposing roles of Ubp3-dependent deubiquitination regulate replicative life span and heat resistance","volume":"33","author":"D \u00d6ling","year":"2014","journal-title":"EMBO J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"9251","DOI":"10.1128\/MCB.23.24.9251-9261.2003","article-title":"Ubiquitin Depletion as a Key Mediator of Toxicity by Translational Inhibitors","volume":"23","author":"J Hanna","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1074\/jbc.M209282200","article-title":"20 S Proteasome from Saccharomyces cerevisiae Is Responsive to Redox Modifications and IsS-Glutathionylated","volume":"278","author":"M Demasi","year":"2003","journal-title":"J Biol Chem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1126\/science.1142210","article-title":"Effects of Aneuploidy on Cellular Physiology and Cell Division in Haploid Yeast","volume":"317","author":"EM Torres","year":"2007","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/oxfordjournals.molbev.a026009","article-title":"Multiple duplications of yeast hexose transport genes in response to selection in a glucose-limited environment","volume":"15","author":"CJ Brown","year":"1998","journal-title":"Mol Biol Evol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16144","DOI":"10.1073\/pnas.242624799","article-title":"Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae","volume":"99","author":"MJ Dunham","year":"2002","journal-title":"Proc Natl Acad Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1001024","DOI":"10.1371\/journal.pgen.1001024","article-title":"Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation","volume":"6","author":"P Fabrizio","year":"2010","journal-title":"PLoS Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ncb1723","article-title":"Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p\/Bre5p ubiquitin protease","volume":"10","author":"C Kraft","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.febslet.2009.12.047","article-title":"Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems","volume":"584","author":"VI Korolchuk","year":"2010","journal-title":"FEBS Lett"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"11079","DOI":"10.1073\/pnas.1302094110","article-title":"Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification","volume":"110","author":"AR Bezerra","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tig.2011.07.003","article-title":"The aneuploidy paradox: costs and benefits of an incorrect karyotype","volume":"27","author":"JM Sheltzer","year":"2011","journal-title":"Trends Genet"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/bies.201200069","article-title":"Whole chromosome aneuploidy: Big mutations drive adaptation by phenotypic leap","volume":"34","author":"G Chen","year":"2012","journal-title":"BioEssays"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cell.2012.11.043","article-title":"Gene Copy-Number Alterations: A Cost-Benefit Analysis","volume":"152","author":"Y-C Tang","year":"2013","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1000705","DOI":"10.1371\/journal.pgen.1000705","article-title":"Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance","volume":"5","author":"AM Selmecki","year":"2009","journal-title":"PLoS Genet"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cell.2008.09.039","article-title":"Aneuploidy Underlies Rapid Adaptive Evolution of Yeast Cells Deprived of a Conserved Cytokinesis Motor","volume":"135","author":"G Rancati","year":"2008","journal-title":"Cell"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"21010","DOI":"10.1073\/pnas.1211150109","article-title":"Chromosomal duplication is a transient evolutionary solution to stress","volume":"109","author":"AH Yona","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1101\/gad.925302","article-title":"Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae","volume":"16","author":"JA Sharp","year":"2002","journal-title":"Genes Dev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1128\/MCB.18.8.4793","article-title":"Hir Proteins Are Required for Position-Dependent Gene Silencing in Saccharomyces cerevisiae in the Absence of Chromatin Assembly Factor I","volume":"18","author":"PD Kaufman","year":"1998","journal-title":"Mol Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature10317","article-title":"Molecular chaperones in protein folding and proteostasis","volume":"475","author":"FU Hartl","year":"2011","journal-title":"Nature"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrm3542","article-title":"Diversity in the origins of proteostasis networks\u2014a driver for protein function in evolution","volume":"14","author":"ET Powers","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tcb.2014.05.003","article-title":"Proteostasis impairment in protein-misfolding and -aggregation diseases","volume":"24","author":"MS Hipp","year":"2014","journal-title":"Trends Cell Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0047-6374(01)00337-2","article-title":"Protein turnover plays a key role in aging","volume":"123","author":"AG Ryazanov","year":"2002","journal-title":"Mech Ageing Dev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.tibs.2014.06.002","article-title":"Protein mistranslation: friend or foe?","volume":"39","author":"L Ribas de Pouplana","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tig.2003.12.009","article-title":"Driving change: the evolution of alternative genetic codes","volume":"20","author":"MAS Santos","year":"2004","journal-title":"Trends Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/yea.1350","article-title":"Evolution of the genetic code in yeasts","volume":"23","author":"I Miranda","year":"2006","journal-title":"Yeast"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1006\/jmbi.1994.1094","article-title":"Transfer RNA Mutation and the Malleability of the Genetic Code","volume":"235","author":"DW Schultz","year":"1994","journal-title":"J Mol Biol"},{"key":"ref58","first-page":"33","article-title":"Yeast Protocols","author":"RD Gietz","year":"2014"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e1001935","DOI":"10.1371\/journal.pbio.1001935","article-title":"The Genomic Landscape of Compensatory Evolution","volume":"12","author":"B Szamecz","year":"2014","journal-title":"PLoS Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0167-4781(92)90503-R","article-title":"Use of a dot blot hybridization method for identification of pure tRNA species on different membranes","volume":"1129","author":"J Heitzler","year":"1992","journal-title":"Biochim Biophys Acta BBA\u2014Gene Struct Expr"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/nar\/18.10.3091","article-title":"A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae","volume":"18","author":"ME Schmitt","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"ref63","first-page":"134","article-title":"Methods in Enzymology","author":"AI Saeed","year":"2006"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1093\/bioinformatics\/btr174","article-title":"BamTools: a C++ API and toolkit for analyzing and managing BAM files","volume":"27","author":"DW Barnett","year":"2011","journal-title":"Bioinformatics"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/nar\/26.1.73","article-title":"SGD: Saccharomyces Genome Database","volume":"26","author":"JM Cherry","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows\u2013Wheeler transform","volume":"26","author":"H Li","year":"2010","journal-title":"Bioinformatics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"}],"container-title":["PLOS Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pbio.1002291","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T09:43:08Z","timestamp":1567330988000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pbio.1002291"}},"subtitle":[],"editor":[{"given":"Nick H.","family":"Barton","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2015,11,6]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pbio.1002291","relation":{},"ISSN":["1545-7885"],"issn-type":[{"value":"1545-7885","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,6]]}}}