{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:17:11Z","timestamp":1775175431027,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pbio.3001615","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000}}],"reference-count":97,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosbiology.org"],"crossmark-restriction":false},"short-container-title":["PLoS Biol"],"abstract":"<jats:p>\n                    Understanding the regulatory interactions that control gene expression during the development of novel tissues is a key goal of evolutionary developmental biology. Here, we show that\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    has undergone a striking process of evolutionary specialization in eutherian mammals resulting in the emergence of a novel placental function for the gene.\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    belongs to a family of RNA-binding proteins whose members regulate multiple aspects of RNA metabolism. We find that, in eutherians, while both\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    and its paralog\n                    <jats:italic>Mbnl2<\/jats:italic>\n                    are strongly expressed in placenta,\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    expression has been lost from nonplacental tissues in association with the evolution of a novel promoter. Moreover,\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    has undergone accelerated protein sequence evolution leading to changes in its RNA-binding specificities and cellular localization. While\n                    <jats:italic>Mbnl2<\/jats:italic>\n                    and\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    share partially redundant roles in regulating alternative splicing, polyadenylation site usage and, in turn, placenta maturation,\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    has also acquired novel biological functions. Specifically,\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    knockout (M3KO) alone results in increased placental growth associated with higher\n                    <jats:italic>Myc<\/jats:italic>\n                    expression. Furthermore,\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    loss increases fetal resource allocation during limiting conditions, suggesting that location of\n                    <jats:italic>Mbnl3<\/jats:italic>\n                    on the X chromosome has led to its role in limiting placental growth, favoring the maternal side of the parental genetic conflict.\n                  <\/jats:p>","DOI":"10.1371\/journal.pbio.3001615","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:38:44Z","timestamp":1651066724000},"page":"e3001615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pbio.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians"],"prefix":"10.1371","volume":"20","author":[{"given":"Thomas","family":"Spruce","sequence":"first","affiliation":[]},{"given":"Mireya","family":"Plass","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9","family":"Gohr","sequence":"additional","affiliation":[]},{"given":"Debashish","family":"Ray","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-6491","authenticated-orcid":true,"given":"Mar\u00eda","family":"Mart\u00ednez de 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