{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:58:28Z","timestamp":1774418308788,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1011499","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000}}],"reference-count":98,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["22231\/01\/SAICT\/2016"],"award-info":[{"award-number":["22231\/01\/SAICT\/2016"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04469\/2020"],"award-info":[{"award-number":["UIDB\/04469\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DFA\/BD\/8076\/2020"],"award-info":[{"award-number":["DFA\/BD\/8076\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DL 57\/2016\/CP1351\/CT0003."],"award-info":[{"award-number":["DL 57\/2016\/CP1351\/CT0003."]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Over the last decade, genome-scale metabolic models have been increasingly used to study plant metabolic behaviour at the tissue and multi-tissue level under different environmental conditions. <jats:italic>Quercus suber<\/jats:italic>, also known as the cork oak tree, is one of the most important forest communities of the Mediterranean\/Iberian region. In this work, we present the genome-scale metabolic model of the <jats:italic>Q<\/jats:italic>. <jats:italic>suber<\/jats:italic> (iEC7871). The metabolic model comprises 7871 genes, 6231 reactions, and 6481 metabolites across eight compartments. Transcriptomics data was integrated into the model to obtain tissue-specific models for the leaf, inner bark, and phellogen, with specific biomass compositions. The tissue-specific models were merged into a diel multi-tissue metabolic model to predict interactions among the three tissues at the light and dark phases. The metabolic models were also used to analyse the pathways associated with the synthesis of suberin monomers, namely the acyl-lipids, phenylpropanoids, isoprenoids, and flavonoids production. The models developed in this work provide a systematic overview of the metabolism of <jats:italic>Q<\/jats:italic>. <jats:italic>suber<\/jats:italic>, including its secondary metabolism pathways and cork formation.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1011499","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T17:38:18Z","timestamp":1695231498000},"page":"e1011499","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The first multi-tissue genome-scale metabolic model of a woody plant highlights suberin biosynthesis pathways in Quercus suber"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0893-0563","authenticated-orcid":true,"given":"Emanuel","family":"Cunha","sequence":"first","affiliation":[]},{"given":"Miguel","family":"Silva","sequence":"additional","affiliation":[]},{"given":"In\u00eas","family":"Chaves","sequence":"additional","affiliation":[]},{"given":"Huseyin","family":"Demirci","sequence":"additional","affiliation":[]},{"given":"Davide Rafael","family":"Lagoa","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Miguel","family":"Rocha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-3410","authenticated-orcid":true,"given":"Isabel","family":"Rocha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-7178","authenticated-orcid":true,"given":"Oscar","family":"Dias","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"pcbi.1011499.ref001","article-title":"Suberin: the biopolyester at the frontier of plants","author":"J. 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