{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T15:33:08Z","timestamp":1770478388833,"version":"3.49.0"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T00:00:00Z","timestamp":1236297600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1000403","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T01:58:20Z","timestamp":1236304700000},"page":"e1000403","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":90,"title":["Death and Resurrection of the Human IRGM Gene"],"prefix":"10.1371","volume":"5","author":[{"given":"Cemalettin","family":"Bekpen","sequence":"first","affiliation":[]},{"given":"Tomas","family":"Marques-Bonet","sequence":"additional","affiliation":[]},{"given":"Can","family":"Alkan","sequence":"additional","affiliation":[]},{"given":"Francesca","family":"Antonacci","sequence":"additional","affiliation":[]},{"given":"Maria Bruna","family":"Leogrande","sequence":"additional","affiliation":[]},{"given":"Mario","family":"Ventura","sequence":"additional","affiliation":[]},{"given":"Jeffrey M.","family":"Kidd","sequence":"additional","affiliation":[]},{"given":"Priscillia","family":"Siswara","sequence":"additional","affiliation":[]},{"given":"Jonathan C.","family":"Howard","sequence":"additional","affiliation":[]},{"given":"Evan E.","family":"Eichler","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"6715","DOI":"10.4049\/jimmunol.161.12.6715","article-title":"Two families of GTPases dominate the complex cellular response to interferon-g.","volume":"161","author":"U Boehm","year":"1998","journal-title":"J Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nri1270","article-title":"p47 GTPases: regulators of immunity to intracellular pathogens.","volume":"4","author":"GA Taylor","year":"2004","journal-title":"Nature Reviews Immunology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.imbio.2007.09.018","article-title":"Emerging themes in IFN-gamma-induced macrophage immunity by the p47 and p65 GTPase families.","volume":"212","author":"AR Shenoy","year":"2007","journal-title":"Immunobiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.imbio.2007.11.005","article-title":"The IRG proteins: A function in search of a mechanism.","volume":"213","author":"J Howard","year":"2008","journal-title":"Immunobiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1088063","article-title":"Immune control of tuberculosis by IFN-gamma-inducible LRG-47.","volume":"302","author":"J MacMicking","year":"2003","journal-title":"Science"},{"key":"ref6","article-title":"Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn&apos;s disease.","author":"SA Fisher","year":"2008","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng2061","article-title":"Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn&apos;s disease susceptibility.","volume":"39","author":"M Parkes","year":"2007","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/gb-2005-6-11-r92","article-title":"The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage.","volume":"6","author":"C Bekpen","year":"2005","journal-title":"Genome Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1242\/jcs.01039","article-title":"IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3.","volume":"117","author":"F Kaiser","year":"2004","journal-title":"J Cell Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/jmbi.2001.5378","article-title":"Classification and evolution of P-loop GTPases and related ATPases.","volume":"317","author":"DD Leipe","year":"2002","journal-title":"J Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1126\/science.1129577","article-title":"Human IRGM induces autophagy to eliminate intracellular mycobacteria.","volume":"313","author":"SB Singh","year":"2006","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature06862","article-title":"Mapping and sequencing of structural variation from eight human genomes.","volume":"453","author":"JM Kidd","year":"2008","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/molbev\/msm088","article-title":"PAML 4: phylogenetic analysis by maximum likelihood.","volume":"24","author":"Z Yang","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s002390010105","article-title":"Maximum likelihood estimation on large phylogenies and analysis of adaptive evolution in human influenza virus A.","volume":"51","author":"Z Yang","year":"2000","journal-title":"J Mol Evol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2164-6-47","article-title":"Transcription of the human and rodent SPAM1\/PH-20 genes initiates within an ancient endogenous retrovirus.","volume":"6","author":"CA Dunn","year":"2005","journal-title":"BMC Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1128\/jvi.76.5.2410-2423.2002","article-title":"The solitary long terminal repeats of ERV-9 endogenous retrovirus are conserved during primate evolution and possess enhancer activities in embryonic and hematopoietic cells.","volume":"76","author":"J Ling","year":"2002","journal-title":"J Virol"},{"key":"ref17","article-title":"A 20-kilobase deletion polymorphism upstream of IRGM is associated with altered IRGM expression and Crohn&apos;s disease.","author":"SA McCarroll","year":"2008","journal-title":"Nature Genetics in press"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.","volume":"22","author":"JD Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","article-title":"Multiple sequence alignment with the Clustal series of programs.","volume":"31","author":"R Chenna","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref20","first-page":"189","article-title":"MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers.","volume":"10","author":"S Kumar","year":"1994","journal-title":"Comput Appl Biosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/oxfordjournals.molbev.a025957","article-title":"Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution.","volume":"15","author":"Z Yang","year":"1998","journal-title":"Mol Biol Evol"}],"container-title":["PLoS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1000403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T07:54:50Z","timestamp":1684914890000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1000403"}},"subtitle":[],"editor":[{"given":"Mikkel H.","family":"Schierup","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,3,6]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2009,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1000403","relation":{},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,6]]}}}