{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:46:11Z","timestamp":1774262771815,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pgen.1007235","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000}}],"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T00:00:00Z","timestamp":1519084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008367","name":"Statens Naturvidenskabelige Forskningsrad","doi-asserted-by":"publisher","award":["11-106302"],"award-info":[{"award-number":["11-106302"]}],"id":[{"id":"10.13039\/100008367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosgenetics.org"],"crossmark-restriction":false},"short-container-title":["PLoS Genet"],"DOI":"10.1371\/journal.pgen.1007235","type":"journal-article","created":{"date-parts":[[2018,2,20]],"date-time":"2018-02-20T13:28:18Z","timestamp":1519133298000},"page":"e1007235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pgen.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["DNA damage as a consequence of NLR activation"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-4980","authenticated-orcid":true,"given":"Eleazar","family":"Rodriguez","sequence":"first","affiliation":[]},{"given":"Jonathan","family":"Chevalier","sequence":"additional","affiliation":[]},{"given":"Hassan","family":"El Ghoul","sequence":"additional","affiliation":[]},{"given":"Kristoffer","family":"Voldum-Clausen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-4588","authenticated-orcid":true,"given":"John","family":"Mundy","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-5991","authenticated-orcid":true,"given":"Morten","family":"Petersen","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"JDG Jones","year":"2006","journal-title":"Nature"},{"key":"ref2","first-page":"1385","article-title":"Making sense of plant autoimmunity and \u201cnegative regulators\u201d","volume":"8","author":"E Rodriguez","year":"2015","journal-title":"FEBS J."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.coi.2015.01.014","article-title":"NLR in Plants","volume":"32","author":"X Li","year":"2016","journal-title":"Curr Opin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10306","DOI":"10.1073\/pnas.95.17.10306","article-title":"Different requirements for EDS 1 and NDR 1 by disease resistance genes define at least two R gene-mediated signaling pathways in <italic>Arabidopsis<\/italic>","volume":"95","author":"N Aarts","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/cdd.2011.37","article-title":"Programmed cell death in the plant immune system","volume":"18","author":"NS Coll","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1005868402827","article-title":"Characterization of nuclease activities and DNA fragmentation induced upon hypersensitive response cell death and mechanical stress","volume":"34","author":"R Mittler","year":"1997","journal-title":"Plant Mol Biol"},{"key":"ref7","first-page":"1","article-title":"Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in <italic>Arabidopsis<\/italic>","volume":"23","author":"Y Ge","year":"2016","journal-title":"Cell Death Differ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/jxb\/erm239","article-title":"The hypersensitive response; the centenary is upon us but how much do we know?","volume":"59","author":"L Mur","year":"2008","journal-title":"J Exp Bot"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.1511182112","article-title":"Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid","volume":"112","author":"X Zheng","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpls.2015.00024","article-title":"To die or not to die? Lessons from lesion mimic mutants","volume":"6","author":"Q Bruggeman","year":"2015","journal-title":"Front Plant Sci"},{"key":"ref11","first-page":"6","article-title":"Autoimmunity in <italic>Arabidopsis acd11<\/italic> Is Mediated by Epigenetic Regulation of an Immune Receptor","author":"K Palma","year":"2010","journal-title":"PLoS Patho"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chom.2012.01.015","article-title":"Disruption of PAMP-induced MAP kinase cascade by a <italic>Pseudomonas syringae<\/italic> effector activates plant immunity mediated by the NB-LRR protein SUMM2","volume":"11","author":"Z Zhang","year":"2012","journal-title":"Cell Host Microbe"},{"issue":"5","key":"ref13","first-page":"1","article-title":"The mRNA decay factor PAT 1 functions in a pathway including MAP kinase 4 and immune receptor SUMM 2","volume":"34","author":"ME Roux","year":"2015","journal-title":"EMBO J"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.chom.2017.03.005","article-title":"Matching NLR Immune Receptors to Autoimmunity in <italic>camta3<\/italic> Mutants Using Antimorphic NLR Alleles","volume":"21","author":"S Lolle","year":"2017","journal-title":"Cell Host Microbe"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.it.2014.06.003","article-title":"DNA damage and innate immunity: Links and trade-offs","volume":"35","author":"G Chatzinikolaou","year":"2014","journal-title":"Trends Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10327-009-0162-4","article-title":"Bacterial DNA activates immunity in Arabidopsis thaliana","volume":"75","author":"S Yakushiji","year":"2009","journal-title":"J Gen Plant Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"H Hemmi","year":"2000","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2008.06.032","article-title":"Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity","volume":"134","author":"DB Stetson","year":"2008","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.molcel.2013.09.019","article-title":"Salicylic acid activates DNA damage responses to potentiate plant immunity","volume":"52","author":"S Yan","year":"2013","journal-title":"Mol Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0092-8674(00)81962-5","article-title":"Identification and Cloning of a Negative Regulator of Systemic Acquired Resistance, SNI1, through a Screen for Suppressors of <italic>npr1-1<\/italic>","volume":"98","author":"X Li","year":"1999","journal-title":"Cell"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"e1004030","DOI":"10.1371\/journal.ppat.1004030","article-title":"Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses","volume":"10","author":"J Song","year":"2014","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1021\/tx2001465","article-title":"Cr(VI) induces DNA damage, cell cycle arrest and polyploidization: a flow cytometric and comet assay study in <italic>Pisum sativum<\/italic>","volume":"24","author":"E Rodriguez","year":"2011","journal-title":"Chem Res Toxicol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1104\/pp.111.192617","article-title":"The U-Box\/ARM E3 Ligase PUB13 Regulates Cell Death, Defense, and Flowering Time in Arabidopsis","volume":"159","author":"W Li","year":"2012","journal-title":"Plant Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1105\/tpc.104.022038","article-title":"Vascular Associated Death1, a novel GRAM domain\u2013containing protein, is a regulator of cell death and defense responses in vascular tissues","volume":"16","author":"B Lin","year":"2004","journal-title":"The Plant Cell"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1073\/pnas.150005697","article-title":"The Arabidopsis dnd1 \u201c\u2018defense, no death \u2018\u201d gene encodes a mutated cyclic nucleotide-gated ion channel","volume":"97","author":"SJ Clough","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.febslet.2008.02.037","article-title":"Calmodulin-binding transcription activator (CAMTA) 3 mediates biotic defense responses in <italic>Arabidopsis<\/italic>","volume":"582","author":"Y Galon","year":"2008","journal-title":"Febs Lett"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1204903","article-title":"Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity","volume":"332","author":"D Lu","year":"2011","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/tpj.12473","article-title":"Regulation of plant immunity through ubiquitin-mediated modulation of Ca(<sup>2+<\/sup>) -calmodulin-AtSR1\/CAMTA3 signaling","volume":"78","author":"L Zhang","year":"2014","journal-title":"Plant J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"22716","DOI":"10.1073\/pnas.1005978107","article-title":"Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses","volume":"107","author":"S Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1128\/MCB.19.4.2986","article-title":"Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage","volume":"19","author":"Y Huang","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref31","first-page":"520","article-title":"Radiation Enhances Caspase 3 Cleavage of Rad51 in BRCA2-","volume":"141","author":"ET Brown","year":"2008","journal-title":"Defective Cells. Radiat Res"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1105\/tpc.107.050641","article-title":"Natural variation among <italic>Arabidopsis thaliana<\/italic> accessions for transcriptome response to exogenous Salicylic acid","volume":"19","author":"H van Leeuwen","year":"2007","journal-title":"The Plant Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1364-3703.2004.00253.x","article-title":"Induction of programmed cell death in lily by the fungal pathogen <italic>Botrytis elliptica<\/italic>","volume":"5","author":"P Van Baarlen","year":"2004","journal-title":"Mol Plant Pathol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.chom.2014.02.010","article-title":"What\u2019s the damage? The impact of pathogens on pathways that maintain host genome integrity","volume":"15","author":"MD Weitzman","year":"2014","journal-title":"Cell Host Microbe"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1104\/pp.112.208942","article-title":"AtMMS21, an SMC5 \/ 6 complex subunit, is involved in stem cell niche maintenance and DNA damage responses in <italic>Arabidopsis<\/italic> roots","volume":"161","author":"P Xu","year":"2013","journal-title":"Plant Physiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.4161\/auto.29406","article-title":"Autophagy deficiency leads to accumulation of ubiquitinated proteins, ER stress, and cell death in <italic>Arabidopsis<\/italic>","volume":"10","author":"D Munch","year":"2014","journal-title":"Autophagy"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1469-8137.2012.04062.x","article-title":"Plant \u03b3H2AX foci are required for proper DNA DSB repair responses and colocalize with E2F factors","volume":"194","author":"J Lang","year":"2012","journal-title":"New Phytologist"}],"updated-by":[{"DOI":"10.1371\/journal.pgen.1007235","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000}}],"container-title":["PLOS Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pgen.1007235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:28:31Z","timestamp":1588962511000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pgen.1007235"}},"subtitle":[],"editor":[{"given":"Jonathan D. G.","family":"Jones","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pgen.1007235","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pgen.1007235","asserted-by":"object"}]},"ISSN":["1553-7404"],"issn-type":[{"value":"1553-7404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,20]]}}}