{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:05:12Z","timestamp":1761581112965},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0002317","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T22:13:48Z","timestamp":1374790428000},"page":"e2317","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival"],"prefix":"10.1371","volume":"7","author":[{"given":"Jo\u00e3o Filipe","family":"Menino","sequence":"first","affiliation":[]},{"given":"Margarida","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Ana G.","family":"Gomes-Alves","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Lobo-Silva","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Sturme","sequence":"additional","affiliation":[]},{"given":"J\u00e9ssica","family":"Gomes-Rezende","sequence":"additional","affiliation":[]},{"given":"Ana Laura","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Gustavo H.","family":"Goldman","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Agostinho","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Luigina","family":"Romani","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Pedrosa","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio Gil","family":"Castro","sequence":"additional","affiliation":[]},{"given":"Fernando","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.6.2.89","article-title":"Paracoccidioidomycosis: an update","volume":"6","author":"E Brummer","year":"1993","journal-title":"Clin Microbiol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/13693780903055673","article-title":"Gene expression analysis of Paracoccidioides brasiliensis transition from conidium to yeast cell","volume":"48","author":"AM Garcia","year":"2010","journal-title":"Med Mycol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3109\/13693786.2012.665614","article-title":"Morphological heterogeneity of Paracoccidioides brasiliensis: relevance of the Rho-like GTPase PbCDC42","volume":"50","author":"JF Menino","year":"2012","journal-title":"Med Mycol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.fgb.2009.08.004","article-title":"Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis","volume":"46","author":"AJ Almeida","year":"2009","journal-title":"Fungal Genet Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/02681218780000231","article-title":"Experimental murine paracoccidiodomycosis induced by the inhalation of conidia","volume":"25","author":"JG McEwen","year":"1987","journal-title":"J Med Vet Mycol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1080\/02681218780000021","article-title":"Host-parasite relationships in paracoccidioidomycosis","volume":"25","author":"M Franco","year":"1987","journal-title":"J Med Vet Mycol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11046-007-9065-0","article-title":"An overview of the immunopathology of human paracoccidioidomycosis","volume":"165","author":"G Benard","year":"2008","journal-title":"Mycopathologia"},{"key":"ref8","first-page":"297","article-title":"[Guidelines in paracoccidioidomycosis]","volume":"39","author":"MA Shikanai-Yasuda","year":"2006","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0008-8749(76)90220-3","article-title":"In vivo and in vitro evaluation of cell-mediated immunity in patients with paracoccidiodomycosis","volume":"24","author":"CC Musatti","year":"1976","journal-title":"Cell Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"CA Janeway Jr","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coi.2005.11.012","article-title":"How Toll-like receptors signal: what we know and what we don't know","volume":"18","author":"LA O'Neill","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"ref12","first-page":"562","article-title":"[Toll-like receptors and innate immune system]","volume":"46","author":"S Akira","year":"2001","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"R Medzhitov","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","article-title":"TLR signaling","volume":"19","author":"T Kawai","year":"2007","journal-title":"Semin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micinf.2003.09.020","article-title":"Toll-like receptor-2 is essential in murine defenses against Candida albicans infections","volume":"6","author":"E Villamon","year":"2004","journal-title":"Microbes Infect"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1365-2141.2004.04922.x","article-title":"Aspergillus fumigatus antigens activate innate immune cells via toll-like receptors 2 and 4","volume":"125","author":"S Braedel","year":"2004","journal-title":"Br J Haematol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4620","DOI":"10.4049\/jimmunol.166.7.4620","article-title":"Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule","volume":"166","author":"S Shoham","year":"2001","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1007\/s10096-004-1192-7","article-title":"Recognition of fungal pathogens by Toll-like receptors","volume":"23","author":"MG Netea","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1086\/340511","article-title":"The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis","volume":"185","author":"MG Netea","year":"2002","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11046-007-9048-1","article-title":"Innate immunity to Paracoccidioides brasiliensis infection","volume":"165","author":"VL Calich","year":"2008","journal-title":"Mycopathologia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1086\/526500","article-title":"Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis","volume":"197","author":"A Carvalho","year":"2008","journal-title":"J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1574-695X.2008.00487.x","article-title":"MyD88 is dispensable for resistance to Paracoccidioides brasiliensis in a murine model of blood-borne disseminated infection","volume":"54","author":"A Gonzalez","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/IAI.00375-10","article-title":"MyD88 signaling is required for efficient innate and adaptive immune responses to Paracoccidioides brasiliensis infection","volume":"79","author":"FV Loures","year":"2011","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3109\/13693780802641425","article-title":"TLR-2, TLR-4 and dectin-1 expression in human monocytes and neutrophils stimulated by Paracoccidioides brasiliensis","volume":"47","author":"CV Bonfim","year":"2009","journal-title":"Med Mycol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.4049\/jimmunol.0801599","article-title":"TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection","volume":"183","author":"FV Loures","year":"2009","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1128\/IAI.01198-09","article-title":"Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells","volume":"78","author":"FV Loures","year":"2010","journal-title":"Infect Immun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.4049\/jimmunol.180.6.4067","article-title":"Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway","volume":"180","author":"K Nakamura","year":"2008","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.imbio.2008.05.002","article-title":"Redundant role of TLR9 for anti-Candida host defense","volume":"213","author":"FL van de Veerdonk","year":"2008","journal-title":"Immunobiology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/IAI.00998-08","article-title":"Toll-like receptor 9 modulates immune responses to Aspergillus fumigatus conidia in immunodeficient and allergic mice","volume":"77","author":"H Ramaprakash","year":"2009","journal-title":"Infect Immun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.00047-08","article-title":"Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA","volume":"76","author":"ZG Ramirez-Ortiz","year":"2008","journal-title":"Infect Immun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.4049\/jimmunol.172.5.3059","article-title":"The contribution of the Toll-like\/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo","volume":"172","author":"S Bellocchio","year":"2004","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1749-6632.2012.06837.x","article-title":"The cell biology of the innate immune response to Aspergillus fumigatus","volume":"1273","author":"MK Mansour","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1365-3083.2001.00937.x","article-title":"Immunostimulatory DNA from Paracoccidioides brasiliensis acts as T-helper 1 promoter in susceptible mice","volume":"54","author":"MC Souza","year":"2001","journal-title":"Scand J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1002\/eji.200425218","article-title":"Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner","volume":"34","author":"M Rutz","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/02681218780000411","article-title":"Nuclear staining of Paracoccidioides brasiliensis conidia","volume":"25","author":"JG McEwen","year":"1987","journal-title":"J Med Vet Mycol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fgb.2006.06.003","article-title":"Genome size and ploidy of Paracoccidioides brasiliensis reveals a haploid DNA content: flow cytometry and GP43 sequence analysis","volume":"44","author":"AJ Almeida","year":"2007","journal-title":"Fungal Genet Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-3083.2005.01680.x","article-title":"Adjuvant effect of synthetic oligodeoxyribonucleotides (CpG-ODN) from the Paracoccidioides brasiliensis gp43 gene on the Th2-Th1 immunomodulation of experimental paracoccidioidomycosis","volume":"62","author":"CC Amaral","year":"2005","journal-title":"Scand J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1128\/IAI.73.10.6299-6310.2005","article-title":"Infection with Mycobacterium ulcerans induces persistent inflammatory responses in mice","volume":"73","author":"MS Oliveira","year":"2005","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1128\/IAI.63.9.3381-3387.1995","article-title":"Susceptibility of beige mice to Mycobacterium avium: role of neutrophils","volume":"63","author":"R Appelberg","year":"1995","journal-title":"Infect Immun"},{"key":"ref40","first-page":"302","article-title":"Neutrophils as effector cells of T-cell-mediated, acquired immunity in murine listeriosis","volume":"83","author":"R Appelberg","year":"1994","journal-title":"Immunology"},{"key":"ref41","first-page":"2898","article-title":"Activation of phosphatidylinositol 3-kinase\/Akt and impairment of nuclear factor-kappaB: molecular mechanisms behind the arrested maturation\/activation state of Leishmania infantum-infected dendritic cells","volume":"177","author":"BM Neves","year":"2010","journal-title":"Am J Pathol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.immuni.2009.09.016","article-title":"Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils","volume":"31","author":"X Zhang","year":"2009","journal-title":"Immunity"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.mib.2008.06.002","article-title":"Host-microbe interactions: innate pattern recognition of fungal pathogens","volume":"11","author":"FL van de Veerdonk","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nature06421","article-title":"Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis","volume":"450","author":"MA Sanjuan","year":"2007","journal-title":"Nature"},{"key":"ref45","first-page":"iii44","article-title":"Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors","volume":"67 Suppl 3","author":"JM Blander","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.49.4.526","article-title":"MIP-2 secreted by epithelial cells increases neutrophil and lymphocyte recruitment in the mouse intestine","volume":"49","author":"Y Ohtsuka","year":"2001","journal-title":"Gut"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"JK Kolls","year":"2004","journal-title":"Immunity"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1182\/blood-2004-08-3193","article-title":"The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner","volume":"105","author":"PC Burdon","year":"2005","journal-title":"Blood"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.molimm.2003.10.005","article-title":"Innate immunity: an overview","volume":"40","author":"B Beutler","year":"2004","journal-title":"Mol Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"L Romani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e1000758","DOI":"10.1371\/journal.ppat.1000758","article-title":"Innate recognition of fungal cell walls","volume":"6","author":"SM Levitz","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-695X.2008.00378.x","article-title":"Toll-like receptors and fungal infections: the role of TLR2, TLR4 and MyD88 in paracoccidioidomycosis","volume":"53","author":"VL Calich","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e26232","DOI":"10.1371\/journal.pone.0026232","article-title":"Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans","volume":"6","author":"JP Wang","year":"2011","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","article-title":"Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death","volume":"90","author":"AB Kulkarni","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000170104","article-title":"Tumor necrosis factor as a mediator of shock, cachexia and inflammation","volume":"11","author":"A Cerami","year":"1993","journal-title":"Blood Purif"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000237369","article-title":"Recent progress in the tumor necrosis factor-alpha field","volume":"111","author":"L Rink","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.pathmechdis.3.121806.151456","article-title":"The inflammatory response to cell death","volume":"3","author":"KL Rock","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/13693780310001610038","article-title":"Production of pro-inflammatory cytokines during the early stages of experimental Paracoccidioides brasiliensis infection","volume":"41","author":"A Gonzalez","year":"2003","journal-title":"Med Mycol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1128\/IAI.00385-10","article-title":"Interleukin-17A during local and systemic Staphylococcus aureus-induced arthritis in mice","volume":"78","author":"L Henningsson","year":"2010","journal-title":"Infect Immun"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1182\/blood-2009-04-216085","article-title":"Evidence for a cross-talk between human neutrophils and Th17 cells","volume":"115","author":"M Pelletier","year":"2010","journal-title":"Blood"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.4049\/jimmunol.173.12.7406","article-title":"TLRs govern neutrophil activity in aspergillosis","volume":"173","author":"S Bellocchio","year":"2004","journal-title":"J Immunol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1002\/eji.200737409","article-title":"IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance","volume":"37","author":"T Zelante","year":"2007","journal-title":"Eur J Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1128\/IAI.73.3.1744-1753.2005","article-title":"Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice","volume":"73","author":"EB Eruslanov","year":"2005","journal-title":"Infect Immun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1084\/jem.20100265","article-title":"Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis","volume":"207","author":"A Cruz","year":"2010","journal-title":"J Exp Med"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.it.2011.10.003","article-title":"Neutrophils in tuberculosis: friend or foe?","volume":"33","author":"DM Lowe","year":"2012","journal-title":"Trends Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/infdis\/166.3.568","article-title":"Enhanced release of elastase and oxidative inactivation of alpha-1-protease inhibitor by stimulated human neutrophils exposed to Pseudomonas aeruginosa pigment 1-hydroxyphenazine","volume":"166","author":"GJ Ras","year":"1992","journal-title":"J Infect Dis"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature06013","article-title":"DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response","volume":"448","author":"A Takaoka","year":"2007","journal-title":"Nature"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature06537","article-title":"TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines","volume":"451","author":"KJ Ishii","year":"2008","journal-title":"Nature"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1084\/jem.20071450","article-title":"Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells","volume":"205","author":"F Gerosa","year":"2008","journal-title":"J Exp Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/eji.200737741","article-title":"Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors","volume":"38","author":"KM Dennehy","year":"2008","journal-title":"Eur J Immunol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1462-5822.2006.00796.x","article-title":"Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2","volume":"9","author":"K Luther","year":"2007","journal-title":"Cell Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1128\/IAI.01455-08","article-title":"Modulation of Toll-like receptor 2 (TLR2) and TLR4 responses by Aspergillus fumigatus","volume":"77","author":"LY Chai","year":"2009","journal-title":"Infect Immun"}],"container-title":["PLoS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0002317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T19:25:32Z","timestamp":1596223532000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0002317"}},"subtitle":[],"editor":[{"given":"Joseph M.","family":"Vinetz","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2013,7,25]]},"references-count":72,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0002317","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,25]]}}}