{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T16:56:40Z","timestamp":1761929800589},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T00:00:00Z","timestamp":1452816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosntds.org"],"crossmark-restriction":false},"short-container-title":["PLoS Negl Trop Dis"],"DOI":"10.1371\/journal.pntd.0004365","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T19:03:27Z","timestamp":1452884607000},"page":"e0004365","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pntd.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity"],"prefix":"10.1371","volume":"10","author":[{"given":"Joana","family":"Faria","sequence":"first","affiliation":[]},{"given":"In\u00eas","family":"Loureiro","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Santar\u00e9m","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Macedo-Ribeiro","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Tavares","sequence":"additional","affiliation":[]},{"given":"Anabela","family":"Cordeiro-da-Silva","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2016,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-065X.2010.00983.x","article-title":"Cell biology and immunology of <italic>Leishmania<\/italic>","volume":"240","author":"E Mougneau","year":"2011","journal-title":"Immunological Reviews"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4103\/0974-777X.62881","article-title":"Leishmaniasis vaccine: where are we today?","volume":"2","author":"L Kedzierski","year":"2010","journal-title":"Journal of Global Infectious Diseases"},{"key":"ref3","first-page":"617521","article-title":"Drug resistance in visceral leishmaniasis","author":"HC Maltezou","year":"2010","journal-title":"Journal of Biomedicine and Biotechnology"},{"key":"ref4","unstructured":"Leishmaniasis. 2014.: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/topics\/leishmaniasis\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/topics\/leishmaniasis\/en\/<\/ext-link>. Accessed July 12, 2015."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molcel.2014.08.018","article-title":"Asparagine plays a critical role in regulating cellular adaption to glutamine depletion","volume":"56","author":"J Zhang","year":"2014","journal-title":"Molecular Cell"},{"key":"ref6","first-page":"291","article-title":"Studies on the utilization of asparagine by mouse leukemia cells","volume":"46","author":"T Ubuka","year":"1971","journal-title":"Journal of National Cancer Institute"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.chom.2008.10.002","article-title":"Metabolic diversity in <italic>Campylobacter jejuni<\/italic> enhances specific tissue colonization","volume":"4","author":"D Hofreuter","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.chom.2012.10.018","article-title":"L-asparaginase II produced by <italic>Salmonella typhimurium<\/italic> inhibits T cell responses and mediates virulence","volume":"12","author":"AL Kullas","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1128\/IAI.00149-10","article-title":"Coupled amino acid deamidase-transport systems essential for <italic>Helicobacter pylori<\/italic> colonization","volume":"78","author":"D Leduc","year":"2010","journal-title":"Infection and Immunity"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e13892","DOI":"10.1371\/journal.pone.0013892","article-title":"Cell cycle inhibition by <italic>Helicobacter pylori<\/italic> L-asparaginase","volume":"5","author":"C Scotti","year":"2010","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1348-0421.2011.00333.x","article-title":"Biochemical and pathophysiological characterization of <italic>Helicobacter pylori<\/italic> asparaginase","volume":"55","author":"K Shibayama","year":"2011","journal-title":"Microbiology and Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e1003928","DOI":"10.1371\/journal.ppat.1003928","article-title":"<italic>Mycobacterium tuberculosis<\/italic> exploits asparagine to assimilate nitrogen and resists stress during infection","volume":"10","author":"A Gouzy","year":"2014","journal-title":"Plos Pathogens"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cell.2013.12.007","article-title":"An extracellular bacterial pathogen modulates host metabolism to regulate its own sensing and proliferation","volume":"156","author":"M Baruch","year":"2014","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/cmi.12227","article-title":"Asparagine assimilation is critical for intracellular replication and dissemination of <italic>Francisella<\/italic>","volume":"16","author":"G Gesbert","year":"2014","journal-title":"Cellular Microbiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nsb0198-15","article-title":"Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase","volume":"5","author":"T Nakatsu","year":"1998","journal-title":"Nature Structural Biology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1271\/bbb.56.376","article-title":"Overexpression and purification of asparagine synthetase from <italic>Escherichia coli<\/italic>","volume":"56","author":"A Sugiyama","year":"1992","journal-title":"Bioscience, Biotechnology and Biochemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/JB.142.1.212-220.1980","article-title":"Genetic and biomedical studies demonstrating a second gene coding for asparagine synthetase in <italic>Escherichia coli<\/italic>","volume":"142","author":"R Humbert","year":"1980","journal-title":"Journal of Bacteriology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/MCB.7.7.2435","article-title":"Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells","volume":"7","author":"IL Andrulis","year":"1987","journal-title":"Molecular Cell Biology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0378-1119(89)90252-7","article-title":"Fine structure analysis of the Chinese hamster AS gene encoding asparagine synthetase","volume":"80","author":"I. L. Andrulis","year":"1989","journal-title":"Gene"},{"key":"ref20","first-page":"373","article-title":"Two asparagine synthetases in <italic>Saccharomyces cerevisiae<\/italic>","volume":"108","author":"F Ramos","year":"1980"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1143609","article-title":"The <italic>Chlamydomonas<\/italic> genome reveals the evolution of key animal and plant functions","volume":"318","author":"SS Merchant","year":"2007","journal-title":"Science"},{"key":"ref22","unstructured":"GC (2003) Primary N-assimilation into amino acids in Arabidopsis. The Arabidopsis Book: American Society of Plant Biologists, Rockville. 17 p."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"12895","DOI":"10.1016\/S0021-9258(19)38244-4","article-title":"Nucleotide sequence of <italic>Escherichia coli<\/italic> asnB and deduced amino acid sequence of asparagine synthetase B","volume":"265","author":"MA Scofield","year":"1990","journal-title":"Journal Biological Chemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1093\/nar\/9.18.4669","article-title":"Nucleotide sequence of the asnA gene coding for asparagine synthetase of <italic>E<\/italic>. <italic>coli<\/italic> K-12","volume":"9","author":"M Nakamura","year":"1981","journal-title":"Nucleic Acids Research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1128\/JB.151.3.1299-1313.1982","article-title":"Asparagine synthetases of <italic>Klebsiella aerogenes<\/italic>: properties and regulation of synthesis","volume":"151","author":"LJ Reitzer","year":"1982","journal-title":"Journal of Bacteriology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jmb.2011.07.050","article-title":"Crystal structure of the archaeal asparagine synthetase: interrelation with aspartyl-tRNA and asparaginyl-tRNA synthetases","volume":"412","author":"M Blaise","year":"2011","journal-title":"Journal of Molecular Biology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1186\/1471-2164-13-621","article-title":"Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from <italic>Leishmania major<\/italic>","volume":"13","author":"VS Gowri","year":"2012","journal-title":"BMC Genomics"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e2578","DOI":"10.1371\/journal.pntd.0002578","article-title":"Knockdown of Asparagine Synthetase A Renders <italic>Trypanosoma brucei<\/italic> Auxotrophic to Asparagine","volume":"7","author":"I Loureiro","year":"2013","journal-title":"Plos Neglected Tropical Diseases"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"12096","DOI":"10.1074\/jbc.M114.554642","article-title":"Identification of functional characterization of a novel bacterial type asparagine synthetase A: a tRNA synthetase paralog from <italic>Leishmania donovani<\/italic>","volume":"289","author":"R Manhas","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1128\/IAI.70.12.6871-6879.2002","article-title":"Genomic scale analysis of <italic>Pasteurella multocida<\/italic> gene expression during growth within the natural chicken host","volume":"70","author":"JD Boyce","year":"2002","journal-title":"Infection and Immunity"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1128\/AAC.50.1.250-255.2006","article-title":"AsnB is involved in natural resistance of <italic>Mycobacterium smegmatis<\/italic> to multiple drugs","volume":"50","author":"H Ren","year":"2006","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2958.2003.03425.x","article-title":"Genes required for mycobacterial growth defined by high density mutagenesis","volume":"48","author":"CM Sassetti","year":"2003","journal-title":"Molecular Microbiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1002251","DOI":"10.1371\/journal.ppat.1002251","article-title":"High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism","volume":"7","author":"JE Griffin","year":"2011","journal-title":"PLoS Pathogens"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2148-7-26","article-title":"Origins of amino acid transporter loci in trypanosomatid parasites","volume":"7","author":"AP Jackson","year":"2007","journal-title":"BMC Evolutionary Biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1042\/BJ20082441","article-title":"Two pathways for cysteine biosynthesis in <italic>Leishmania major<\/italic>","volume":"420","author":"RAM Williams","year":"2009","journal-title":"Biochemical Journal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1469","DOI":"10.1371\/journal.pntd.0001469","article-title":"Impact of Continuous Axenic Cultivation in <italic>Leishmania infantum<\/italic> Virulence","volume":"6","author":"D Moreira","year":"2012","journal-title":"Plos Neglected Tropical Diseases"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and Clustal X version 2.0","volume":"23","author":"MA Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1107\/S0907444909007835","article-title":"ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments","volume":"65","author":"CS Bond","year":"2009","journal-title":"Acta Crystallographic D Biological Crystallogaphyr"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"K Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"D387","DOI":"10.1093\/nar\/gkn750","article-title":"The SWISS-MODEL Repository and associated resources","volume":"37","author":"F Kiefer","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0968-0004(00)88963-X","article-title":"The Swiss-3DImage collection and PDB-Browser on the World-Wide Web","volume":"20","author":"MC Peitsch","year":"1995","journal-title":"Trends Biochemical Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.1112680","article-title":"The Genome of the Kinetoplastid Parasite, <italic>Leishmania major<\/italic>","volume":"309","author":"AC Ivens","year":"2005","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1112181","article-title":"Comparative genomics of trypanosomatid parasitic protozoa","volume":"309","author":"NM El-Sayed","year":"2005","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"D415","DOI":"10.1093\/nar\/gkp941","article-title":"EuPathDB: a portal to eukaryotic databases","volume":"38","author":"C Aurrecoechea","year":"2010","journal-title":"Nucleic Acid Research"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1006\/abio.1993.1264","article-title":"A specific quantitative colorimetric assay for L-asparagine","volume":"211","author":"S Sheng","year":"1993","journal-title":"Analytical Biochemistry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jprot.2013.03.012","article-title":"Exoproteome dynamics in <italic>Leishmania infantum<\/italic>","volume":"84","author":"N Santar\u00e9m","year":"2013","journal-title":"Journal of Proteomics"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.179.5.3161","article-title":"SIR2-deficient <italic>Leishmania infantum<\/italic> induces a defined IFN-gamma\/IL-10 pattern that correlates with protection","volume":"179","author":"R Silvestre","year":"2007","journal-title":"Journal of Immunology"},{"key":"ref48","first-page":"2143","article-title":"Glycosome turnover in <italic>Leishmania major<\/italic> is mediated by autophagy","volume":"12","author":"B Cull","year":"2015","journal-title":"Autophagy"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-3024.2012.01361.x","article-title":"Characterization of <italic>Leishmania infantum<\/italic> thiol-dependent reductase 1 and evaluation of its potential to induce immune protection","volume":"34","author":"AM Silva","year":"2012","journal-title":"Parasite Immunology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e86073","DOI":"10.1371\/journal.pone.0086073","article-title":"Characterization of glycolytic enzymes-rAldolase and rEnolase of <italic>Leishmania donovani<\/italic>, identified as Th1 stimulatory proteins, for their immunogenicity and immunoprophylactic efficacies against experimental visceral leishmaniasis","volume":"9","author":"R Gupta","year":"2014","journal-title":"Plos one"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1074\/jbc.273.3.1534","article-title":"Localization and targeting of the <italic>Leishmania donovani<\/italic> Hypoxanthine-Guanine Phosphoribosyltransferase to the glycosome","volume":"273","author":"S Shih","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1016\/S0021-9258(17)36392-5","article-title":"The asparagine synthetase of <italic>Escherichia coli<\/italic>. II. Studies on mechanism","volume":"244","author":"H Cedar","year":"1969","journal-title":"Journal of Biological Chemistry"},{"key":"ref53","first-page":"4112","article-title":"The asparagine synthetase of <italic>Escherichia coli<\/italic>. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products","volume":"244","author":"H Cedar","year":"1969","journal-title":"Journal of Biological Chemistry"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"16146","DOI":"10.1021\/bi9915768","article-title":"Three-dimensional structure of <italic>Escherichia coli<\/italic> asparagine synthetase B: a short journey from substrate to product","volume":"38","author":"TM Larsen","year":"1999","journal-title":"Biochemistry"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1016\/S0021-9258(17)37307-6","article-title":"Glutamine-dependent nitrogen transfer in <italic>Escherichia coli<\/italic> asparagine synthetase B. Searching for the catalytic triad","volume":"269","author":"SK Boehlein","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.plaphy.2010.12.006","article-title":"A kinetic comparison of asparagine synthetase isozymes from higher plants","volume":"49","author":"SM Duff","year":"2011","journal-title":"Plant Physiology and Biochemistry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1016\/S0021-9258(19)44748-0","article-title":"Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition","volume":"247","author":"B Horowitz","year":"1972","journal-title":"Journal of Biological Chemistry"},{"key":"ref58","unstructured":"Ebikeme C (2007) Amino Acid Transporters &amp; Amino Acid Metabolism in <italic>Trypanosoma brucei<\/italic> brucei. Doctor of Philosophy Thesis, Division of Infection &amp; Immunity Faculty of Biomedical &amp; Life Sciences-University of Glasgow."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1158\/0008-5472.CAN-11-1891","article-title":"Stress regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a\/ARF cell senescence factors","volume":"72","author":"M Horiguchi","year":"2012","journal-title":"Cancer Research"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/emboj.2010.81","article-title":"The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation","volume":"29","author":"J Ye","year":"2010","journal-title":"The EMBO Journal"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1096\/fj.10-157529","article-title":"Multiple levels of gene regulation mediate differentiation of the intracellular pathogen <italic>Leishmania<\/italic>","volume":"25","author":"T Lahav","year":"2011","journal-title":"FASEB Journal"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e19118","DOI":"10.1371\/journal.pone.0019118","article-title":"Intracellular Eukaryotic Parasites Have a Distinct Unfolded Protein Response","volume":"6","author":"SJC Gosline","year":"2011","journal-title":"Plos One"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1462-5822.2011.01602.x","article-title":"Promastigote to amastigote differentiation of <italic>Leishmania<\/italic> is markedly delayed in the absence of PERK eIF2alpha kinase-dependent eIF2alpha phosphorylation","volume":"13","author":"C Chow","year":"2011","journal-title":"Cellular Microbiology"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1128\/EC.00249-07","article-title":"Novel Membrane-Bound eIF2 Kinase in the Flagellar Pocket of <italic>Trypanosoma brucei<\/italic>","volume":"6","author":"MCS Moraes","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1471-4922(01)01895-5","article-title":"Is lipophosphoglycan a virulence factor? A surprising diversity between <italic>Leishmania<\/italic> species","volume":"5","author":"SJ Turco","year":"2001","journal-title":"Trends in Parasitology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1073\/pnas.90.4.1599","article-title":"Plasticity in chromosome number and testing of essential genes in <italic>Leishmania<\/italic> by targeting","volume":"90","author":"AK Cruz","year":"1993","journal-title":"PNAS"},{"issue":"21","key":"ref67","doi-asserted-by":"crossref","first-page":"13883","DOI":"10.1074\/jbc.272.21.13883","article-title":"The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite <italic>Leishmania major<\/italic>","volume":"272","author":"B Nare","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"issue":"16","key":"ref68","doi-asserted-by":"crossref","first-page":"12759","DOI":"10.1074\/jbc.M112.346502","article-title":"Genetic Dissection of Pyrimidine Biosynthesis and Salvage in <italic>Leishmania donovani<\/italic>","volume":"287","author":"ZN Wilson","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"ref69","first-page":"2423","article-title":"Asparaginases: biochemical pharmacology and modes of drug resistance","volume":"32","author":"VI Avramis","year":"2012","journal-title":"Anticancer Research"}],"container-title":["PLOS Neglected Tropical Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pntd.0004365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T19:37:52Z","timestamp":1654112272000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pntd.0004365"}},"subtitle":[],"editor":[{"given":"Michael","family":"Pollastri","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2016,1,15]]},"references-count":69,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pntd.0004365","relation":{},"ISSN":["1935-2735"],"issn-type":[{"value":"1935-2735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,15]]}}}