{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:27:04Z","timestamp":1768544824127,"version":"3.49.0"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2007,10,3]],"date-time":"2007-10-03T00:00:00Z","timestamp":1191369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0000996","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T16:07:51Z","timestamp":1193242071000},"page":"e996","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["A Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans"],"prefix":"10.1371","volume":"2","author":[{"given":"Isabel","family":"Miranda","sequence":"first","affiliation":[]},{"given":"Rita","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"Maria C.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Denisa D.","family":"Mateus","sequence":"additional","affiliation":[]},{"given":"Gabriela R.","family":"Moura","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Carreto","sequence":"additional","affiliation":[]},{"given":"Manuel A. S.","family":"Santos","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2007,10,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tig.2003.12.009","article-title":"Driving change: the evolution of alternative genetic codes.","volume":"20","author":"MA Santos","year":"2004","journal-title":"Trends Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/yea.1350","article-title":"Evolution of the genetic code in yeasts.","volume":"23","author":"I Miranda","year":"2006","journal-title":"Yeast"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s002390010220","article-title":"How mitochondria redefine the code.","volume":"53","author":"RD Knight","year":"2001","journal-title":"J Mol Evol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1073\/pnas.95.7.3703","article-title":"Codon reassignment and amino acid composition in hemichordate mitochondria.","volume":"95","author":"J Castresana","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/35047500","article-title":"Rewiring the keyboard: evolvability of the genetic code.","volume":"2","author":"RD Knight","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1128\/jb.173.5.1810-1812.1991","article-title":"UGA can be decoded as tryptophan at low efficiency in Bacillus subtilis.","volume":"173","author":"PS Lovett","year":"1991","journal-title":"J Bacteriol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/314185a0","article-title":"Does Paramecium primaurelia use a different genetic code in its macronucleus?","volume":"314","author":"F Caron","year":"1985","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1073\/pnas.86.9.3252","article-title":"Differential use of termination codons in ciliated protozoa.","volume":"86","author":"DS Harper","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0960-9822(03)00126-X","article-title":"A new noncanonical nuclear genetic code: translation of UAA into glutamate.","volume":"13","author":"R Sanchez-Silva","year":"2003","journal-title":"Curr Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1128\/EC.2.5.1076-1090.2003","article-title":"Developmentally regulated chromosome fragmentation linked to imprecise elimination of repeated sequences in paramecia.","volume":"2","author":"A Le Mouel","year":"2003","journal-title":"Eukaryot Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0300-9084(97)86722-3","article-title":"Codon reassignment in Candida species: an evolutionary conundrum.","volume":"78","author":"MF Tuite","year":"1996","journal-title":"Biochimie"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF02198859","article-title":"CUG codons in <italic>Candida<\/italic> spp.","volume":"42","author":"TH Jukes","year":"1996","journal-title":"J Mol Evol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0723-2020(99)80030-7","article-title":"Non-universal usage of the leucine CUG codon and the molecular phylogeny of the genus Candida.","volume":"22","author":"T Sugita","year":"1999","journal-title":"Syst Appl Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/j.1460-2075.1986.tb04360.x","article-title":"Dramatic events in ciliate evolution: alteration of UAA and UAG termination codons to glutamine codons due to anticodon mutations in two Tetrahymena tRNAs.","volume":"5","author":"N Hanyu","year":"1986","journal-title":"EMBO J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1126\/science.1069556","article-title":"A new UAG-encoded residue in the structure of a methanogen methyltransferase.","volume":"296","author":"B Hao","year":"2002","journal-title":"Science"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9724","DOI":"10.1016\/S0021-9258(18)81714-8","article-title":"Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA.","volume":"264","author":"BJ Lee","year":"1989","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1128\/JB.183.18.5414-5425.2001","article-title":"Selection and characterization of Escherichia coli variants capable of growth on an otherwise toxic tryptophan analogue.","volume":"183","author":"JM Bacher","year":"2001","journal-title":"J Bacteriol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1073\/pnas.0409064102","article-title":"Inhibited cell growth and protein functional changes from an editing-defective tRNA synthetase.","volume":"102","author":"JM Bacher","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.chembiol.2006.08.011","article-title":"Global effects of mistranslation from an editing defect in mammalian cells.","volume":"13","author":"LA Nangle","year":"2006","journal-title":"Chem Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.1084772","article-title":"An expanded eukaryotic genetic code.","volume":"301","author":"JW Chin","year":"2003","journal-title":"Science"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.biochem.73.012803.092429","article-title":"Incorporation of nonnatural amino acids into proteins.","volume":"73","author":"TL Hendrickson","year":"2004","journal-title":"Annu Rev Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/j.1460-2075.1996.tb00886.x","article-title":"Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans.","volume":"15","author":"MA Santos","year":"1996","journal-title":"Embo J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/nar\/23.9.1481","article-title":"The CUG codon is decoded in vivo as serine and not leucine in Candida albicans.","volume":"23","author":"MA Santos","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1093\/nar\/21.17.4039","article-title":"Non-universal decoding of the leucine codon CUG in several Candida species.","volume":"21","author":"T Ohama","year":"1993","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1093\/emboj\/16.5.1122","article-title":"The \u2018polysemous\u2019 codon--a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.","volume":"16","author":"T Suzuki","year":"1997","journal-title":"Embo J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/j.1460-2075.1993.tb05693.x","article-title":"Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5\u2032-CAG-3\u2032 (leucine) anticodon.","volume":"12","author":"MA Santos","year":"1993","journal-title":"Embo J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1006\/jmbi.1999.3209","article-title":"The Candida albicans CUG-decoding ser-tRNA has an atypical anticodon stem-loop structure.","volume":"293","author":"VM Perreau","year":"1999","journal-title":"J Mol Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF02352290","article-title":"On malleability in the genetic code.","volume":"42","author":"DW Schultz","year":"1996","journal-title":"J Mol Evol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1006\/jmbi.1994.1094","article-title":"Transfer RNA mutation and the malleability of the genetic code.","volume":"235","author":"DW Schultz","year":"1994","journal-title":"J Mol Biol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1101\/gr.811003","article-title":"Comparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp.","volume":"13","author":"SE Massey","year":"2003","journal-title":"Genome Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"24712","DOI":"10.1016\/S0021-9258(18)54288-5","article-title":"Direct analysis of aminoacylation levels of tRNAs in vivo. Application to studying recognition of Escherichia coli initiator tRNA mutants by glutaminyl-tRNA synthetase.","volume":"266","author":"U Varshney","year":"1991","journal-title":"J Biol Chem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0168-9525(00)02144-2","article-title":"Codon reassignment and the evolving genetic code: problems and pitfalls in post-genome analysis.","volume":"17","author":"JM O'Sullivan","year":"2001","journal-title":"Trends Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/1097-0061(20010315)18:4<313::AID-YEA673>3.0.CO;2-7","article-title":"Seryl-tRNA synthetase is not responsible for the evolution of CUG codon reassignment in Candida albicans.","volume":"18","author":"JM O'Sullivan","year":"2001","journal-title":"Yeast"},{"key":"ref34","first-page":"123","article-title":"Phenotypic Switching.","author":"DR Soll","year":"2002","journal-title":"Candida and Candidiasis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0966-842X(01)01984-9","article-title":"The ALS gene family of Candida albicans.","volume":"9","author":"LL Hoyer","year":"2001","journal-title":"Trends Microbiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1128\/IAI.66.4.1783-1786.1998","article-title":"Expression of the Candida albicans gene ALS1 in Saccharomyces cerevisiae induces adherence to endothelial and epithelial cells.","volume":"66","author":"Y Fu","year":"1998","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4948","DOI":"10.1128\/IAI.72.9.4948-4955.2004","article-title":"Global cell surface conformational shift mediated by a Candida albicans adhesin.","volume":"72","author":"JM Rauceo","year":"2004","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/15419060212187","article-title":"Candida albicans and Saccharomyces cerevisiae expressing ALA1\/ALS5 adhere to accessible threonine, serine, or alanine patches.","volume":"9","author":"NK Gaur","year":"2002","journal-title":"Cell Commun Adhes"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1128\/IAI.67.11.6040-6047.1999","article-title":"Overexpression of the Candida albicans ALA1 gene in Saccharomyces cerevisiae results in aggregation following attachment of yeast cells to extracellular matrix proteins, adherence properties similar to those of Candida albicans.","volume":"67","author":"NK Gaur","year":"1999","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1128\/IAI.65.12.5289-5294.1997","article-title":"Expression, cloning, and characterization of a Candida albicans gene, ALA1, that confers adherence properties upon Saccharomyces cerevisiae for extracellular matrix proteins.","volume":"65","author":"NK Gaur","year":"1997","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1128\/EC.2.6.1266-1273.2003","article-title":"EAP1, a Candida albicans gene involved in binding human epithelial cells.","volume":"2","author":"F Li","year":"2003","journal-title":"Eukaryot Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1128\/IAI.63.5.1993-1998.1995","article-title":"Evidence implicating phospholipase as a virulence factor of Candida albicans.","volume":"63","author":"AS Ibrahim","year":"1995","journal-title":"Infect Immun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","article-title":"Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis.","volume":"67","author":"JR Naglik","year":"2003","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1462-5822.2002.00206.x","article-title":"Adhesion in Candida spp.","volume":"4","author":"P Sundstrom","year":"2002","journal-title":"Cell Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/CMR.13.1.122-143.2000","article-title":"Potential role of phospholipases in virulence and fungal pathogenesis.","volume":"13","author":"MA Ghannoum","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"12807","DOI":"10.1073\/pnas.0605138103","article-title":"Epigenetic properties of white-opaque switching in Candida albicans are based on a self-sustaining transcriptional feedback loop.","volume":"103","author":"RE Zordan","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1073\/pnas.0605270103","article-title":"Bistable expression of WOR1, a master regulator of white-opaque switching in Candida albicans.","volume":"103","author":"G Huang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.283.5407.1535","article-title":"Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1.","volume":"283","author":"JF Staab","year":"1999","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1046\/j.1365-2958.2003.03358.x","article-title":"A screen in Saccharomyces cerevisiae identified CaMCM1, an essential gene in Candida albicans crucial for morphogenesis.","volume":"47","author":"M Rottmann","year":"2003","journal-title":"Mol Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/sj.emboj.7600195","article-title":"Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.","volume":"23","author":"X Zheng","year":"2004","journal-title":"EMBO J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1126\/science.285.5431.1271","article-title":"Identification of a mating type-like locus in the asexual pathogenic yeast Candida albicans.","volume":"285","author":"CM Hull","year":"1999","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0092-8674(02)00837-1","article-title":"White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating.","volume":"110","author":"MG Miller","year":"2002","journal-title":"Cell"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/(SICI)1097-0061(20000330)16:5<411::AID-YEA532>3.0.CO;2-N","article-title":"High-frequency occurrence of chromosome translocation in a mutant strain of Candida albicans by a suppressor mutation of ploidy shift.","volume":"16","author":"SI Iwaguchi","year":"2000","journal-title":"Yeast"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1128\/jb.176.11.3345-3353.1994","article-title":"Correlation between polyploidy and auxotrophic segregation in the imperfect yeast Candida albicans.","volume":"176","author":"T Suzuki","year":"1994","journal-title":"J Bacteriol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/emboj\/cdg235","article-title":"Completion of a parasexual cycle in Candida albicans by induced chromosome loss in tetraploid strains.","volume":"22","author":"RJ Bennett","year":"2003","journal-title":"EMBO J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1126\/science.289.5477.310","article-title":"Induction of mating in Candida albicans by construction of MTLa and MTLalpha strains.","volume":"289","author":"BB Magee","year":"2000","journal-title":"Science"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1126\/science.289.5477.307","article-title":"Evidence for mating of the \u201casexual\u201d yeast Candida albicans in a mammalian host.","volume":"289","author":"CM Hull","year":"2000","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1093\/nar\/17.10.3783","article-title":"Comparison of the separation of Candida albicans chromosome-sized DNA by pulsed-field gel electrophoresis techniques.","volume":"17","author":"BA Lasker","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"ref59","first-page":"425","article-title":"Electrophoretic karyotypes and chromosome numbers in Candida species.","volume":"133","author":"BB Magee","year":"1987","journal-title":"J Gen Microbiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1365-2958.1997.5891961.x","article-title":"The non-standard genetic code of Candida spp.: an evolving genetic code or a novel mechanism for adaptation?","volume":"26","author":"MA Santos","year":"1997","journal-title":"Mol Microbiol"},{"key":"ref61","first-page":"279","article-title":"Standard and nonstandard mRNA decoding in Candida.","author":"JM O'Sullivan","year":"2002","journal-title":"Candida and Candidiasis"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1002\/j.1460-2075.1994.tb06615.x","article-title":"The exchange of the discriminator base A73 for G is alone sufficient to convert human tRNA(Leu) into a serine-acceptor in vitro.","volume":"13","author":"K Breitschopf","year":"1994","journal-title":"EMBO J"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/j.1460-2075.1996.tb00886.x","article-title":"Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans.","volume":"15","author":"MA Santos","year":"1996","journal-title":"EMBO J"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/j.1365-2958.2005.04492.x","article-title":"Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains.","volume":"55","author":"A Selmecki","year":"2005","journal-title":"Mol Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1099\/00221287-139-6-1195","article-title":"Multiple chromosomal and phenotypic changes in spontaneous mutants of Candida albicans.","volume":"139 Pt 6","author":"EP Rustchenko-Bulgac","year":"1993","journal-title":"J Gen Microbiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1128\/jb.172.3.1276-1283.1990","article-title":"Chromosomal rearrangements associated with morphological mutants provide a means for genetic variation of Candida albicans.","volume":"172","author":"EP Rustchenko-Bulgac","year":"1990","journal-title":"J Bacteriol"},{"key":"ref67","first-page":"425","article-title":"High frequency variation of colony morphology and chromosome reorganization in the pathogenic yeast Candida albicans.","volume":"135","author":"T Suzuki","year":"1989","journal-title":"J Gen Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1128\/JB.181.13.4041-4049.1999","article-title":"Specific chromosome alterations in fluconazole-resistant mutants of Candida albicans.","volume":"181","author":"V Perepnikhatka","year":"1999","journal-title":"J Bacteriol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1099\/00221287-143-5-1765","article-title":"Variation in assimilating functions occurs in spontaneous Candida albicans mutants having chromosomal alterations.","volume":"143 ( Pt 5)","author":"EP Rustchenko","year":"1997","journal-title":"Microbiology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.1073\/pnas.95.9.5150","article-title":"Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans.","volume":"95","author":"G Janbon","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/j.1365-2958.2004.04068.x","article-title":"Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation.","volume":"52","author":"M Legrand","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2958.2002.02847.x","article-title":"Expression of mutant alanine tRNAs increases spontaneous mutagenesis in Escherichia coli.","volume":"44","author":"R Dorazi","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.1073\/pnas.0401648101","article-title":"The diploid genome sequence of Candida albicans.","volume":"101","author":"T Jones","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature05096","article-title":"Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.","volume":"443","author":"JW Lee","year":"2006","journal-title":"Nature"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1046\/j.1365-2958.1999.01233.x","article-title":"Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp.","volume":"31","author":"MA Santos","year":"1999","journal-title":"Mol Microbiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/(SICI)1097-0061(199612)12:16<1677::AID-YEA79>3.0.CO;2-U","article-title":"Understanding Candida albicans at the molecular level.","volume":"12","author":"J Pla","year":"1996","journal-title":"Yeast"},{"key":"ref77","article-title":"Molecular cloning: a laboratory manual.","author":"J Sambrook","year":"1989"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/jb.176.1.232-239.1994","article-title":"Coexpression of eukaryotic tRNASer and yeast seryl-tRNA synthetase leads to functional amber suppression in Escherichia coli.","volume":"176","author":"I Weygand-Durasevic","year":"1994","journal-title":"J Bacteriol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0167-4781(92)90503-R","article-title":"Use of a dot blot hybridization method for identification of pure tRNA species on different membranes.","volume":"1129","author":"J Heitzler","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref80","article-title":"PCR protocols: A Guide to Methods and Applications.","author":"MA Innis","year":"1990"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0076-6879(91)94030-G","article-title":"Preparation of high molecular weight RNA.","volume":"194","author":"K Kohrer","year":"1991","journal-title":"Methods Enzymol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1021\/ac00002a010","article-title":"Statistical Treatment for Rejection of Deviant Values - Critical-Values of Dixon Q Parameter and Related Subrange Ratios at the 95-Percent Confidence Level.","volume":"63","author":"DB Rorabacher","year":"1991","journal-title":"Analytical Chemistry"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/00362178485380331","article-title":"Factors affecting the phospholipase activity of Candida species in vitro.","volume":"22","author":"LP Samaranayake","year":"1984","journal-title":"Sabouraudia"},{"key":"ref84","first-page":"11.13.1","article-title":"Cell Cycle Analysis of Yeasts.","author":"M Fortuna","year":"2000","journal-title":"Current Protocols in Cytometry"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"6637","DOI":"10.1128\/jb.175.20.6637-6651.1993","article-title":"Construction of an SfiI macrorestriction map of the Candida albicans genome.","volume":"175","author":"WS Chu","year":"1993","journal-title":"J Bacteriol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0000996","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T04:12:56Z","timestamp":1629951176000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0000996"}},"subtitle":[],"editor":[{"given":"Rosemary","family":"Redfield","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2007,10,3]]},"references-count":85,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2007,10,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0000996","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,3]]}}}