{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T21:22:30Z","timestamp":1773523350124,"version":"3.50.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T00:00:00Z","timestamp":1217980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0002899","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T21:41:07Z","timestamp":1217972467000},"page":"e2899","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":94,"title":["Transthyretin Protects against A-Beta Peptide Toxicity by Proteolytic Cleavage of the Peptide: A Mechanism Sensitive to the Kunitz Protease Inhibitor"],"prefix":"10.1371","volume":"3","author":[{"given":"Rita","family":"Costa","sequence":"first","affiliation":[]},{"given":"Frederico","family":"Ferreira-da-Silva","sequence":"additional","affiliation":[]},{"given":"Maria J.","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Cardoso","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2008,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","article-title":"A beta oligomers - a decade of discovery.","volume":"101","author":"DM Walsh","year":"2007","journal-title":"J Neurochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2119\/2007-00034.Bellucci","article-title":"Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer&apos;s disease.","volume":"13","author":"C Bellucci","year":"2007","journal-title":"Mol Med"},{"key":"ref3","article-title":"Evidence that CD147 modulation of Abeta levels is mediated by extracellular degradation of secreted Abeta.","author":"KS Vetrivel","year":"2008","journal-title":"J Biol Chem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"24540","DOI":"10.1074\/jbc.M007579200","article-title":"Degradation of the Alzheimer&apos;s amyloid beta peptide by endothelin-converting enzyme.","volume":"276","author":"EA Eckman","year":"2001","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"30471","DOI":"10.1074\/jbc.M605827200","article-title":"Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.","volume":"281","author":"EA Eckman","year":"2005","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nbd.2007.12.005","article-title":"LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model.","volume":"30","author":"B Nazer","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref7","article-title":"Amyloid beta-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin.","author":"E Malito","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1073\/pnas.91.18.8368","article-title":"Transthyretin sequesters amyloid beta protein and prevents amyloid formation.","volume":"91","author":"AL Schwarzman","year":"1994","journal-title":"Proc Natl Acad Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/bbrc.1999.0623","article-title":"Binding of gelsolin, a secretory protein, to amyloid beta-protein.","volume":"258","author":"VP Chauhan","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/nm1202-793","article-title":"Serum insulin-like growth factor I regulates brain amyloid-beta levels.","volume":"8","author":"E Carro","year":"2002","journal-title":"Nat Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.1523\/JNEUROSCI.22-17-07380.2002","article-title":"Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.","volume":"22","author":"TD Stein","year":"2002","journal-title":"J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1523\/JNEUROSCI.2211-04.2004","article-title":"Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.","volume":"24","author":"TD Stein","year":"2004","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7006","DOI":"10.1523\/JNEUROSCI.1919-07.2007","article-title":"Accelerated A-Beta deposition in APPswe\/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).","volume":"27","author":"SH Choi","year":"2007","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"11793","DOI":"10.1016\/S0021-9258(17)39100-7","article-title":"Demonstration of transthyretin mRNA in the brain and other extrahepatic tissues in the rat.","volume":"260","author":"DR Soprano","year":"1985","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1172\/JCI105861","article-title":"The contribution of thyroxine-binding prealbumin to the binding of thyroxine in human serum, as assessed by immunoadsorption.","volume":"47","author":"KA Woeber","year":"1968","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"21431","DOI":"10.1074\/jbc.M402212200","article-title":"Transthyretin, a new cryptic protease.","volume":"279","author":"MA Liz","year":"2004","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1194\/jlr.M700158-JLR200","article-title":"ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity.","volume":"48","author":"MA Liz","year":"2007","journal-title":"J Lipid Res"},{"key":"ref18","first-page":"146","article-title":"Interaction of transthyretin with amyloid beta-protein: binding and inhibition of amyloid formation.","volume":"199","author":"AL Schwarzman","year":"1996","journal-title":"Ciba Found Symp"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.febslet.2008.02.034","article-title":"Transthyretin binding to A-Beta peptide-impact on A-Beta fibrillogenesis and toxicity.","volume":"582","author":"R Costa","year":"2008","journal-title":"FEBS Lett"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1073\/pnas.92.20.9368","article-title":"Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans.","volume":"92","author":"CD Link","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1073\/pnas.0712197105","article-title":"Transthyretin protects Alzheimer&apos;s mice from the behavioral and biochemical effects of Abeta toxicity.","volume":"105","author":"JN Buxbaum","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0304-3940(96)12334-X","article-title":"Transthyretin gene in Alzheimer&apos;s disease patients.","volume":"204","author":"JA Palha","year":"1996","journal-title":"Neurosci Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.molmed.2005.08.004","article-title":"Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer&apos;s disease.","volume":"11","author":"ER Vardy","year":"2005","journal-title":"Trends Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.drudis.2006.08.004","article-title":"Clearance of amyloid-beta in Alzheimer&apos;s disease: progress, problems and perspectives.","volume":"11","author":"YJ Wang","year":"2006","journal-title":"Drug Discov Today"},{"key":"ref25","first-page":"58406","article-title":"beta-Amyloid Degradation and Alzheimer&apos;s Disease.","volume":"2006","author":"DS Wang","year":"2006","journal-title":"J Biomed Biotechnol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1021\/bi00223a017","article-title":"Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP).","volume":"30","author":"H Furuya","year":"1991","journal-title":"Biochemistry"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF02820508","article-title":"Thyroxine binding to transthyretin Met 119. Comparative studies of different heterozygotic carriers and structural analysis.","volume":"6","author":"MR Almeida","year":"1997","journal-title":"Endocrine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent.","volume":"193","author":"OH Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2174\/1567205053585918","article-title":"LRP-mediated clearance of Abeta is inhibited by KPI-containing isoforms of APP.","volume":"2","author":"RD Moir","year":"2005","journal-title":"Curr Alzheimer Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/jnnp.63.4.506","article-title":"Cerebrospinal fluid transthyretin: aging and late onset Alzheimer&apos;s disease.","volume":"63","author":"JM Serot","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1179\/016164106X98035","article-title":"Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer&apos;s disease and non-demented elderly subjects.","volume":"28","author":"EM Castano","year":"2006","journal-title":"Neurol Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3109\/13506129808995290","article-title":"Structural and kinetic features of amyloid beta-protein fibrillogenesis.","volume":"5","author":"DB Teplow","year":"1998","journal-title":"Amyloid"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1038\/399a023","article-title":"Translating cell biology into therapeutic advances in Alzheimer&apos;s disease.","volume":"399","author":"DJ Selkoe","year":"1999","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/21637","article-title":"A stop- codon mutation in the BRI gene associated with familial British dementia.","volume":"399","author":"R Vidal","year":"1999","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1016\/S1074-5521(00)00068-5","article-title":"Neurodegeneration: new clues on inclusions.","volume":"7","author":"PT Lansbury Jr","year":"2000","journal-title":"Chem Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"8669","DOI":"10.1073\/pnas.96.15.8669","article-title":"Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid.","volume":"96","author":"B Haggqvist","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1046\/j.1523-1755.1999.00426.x","article-title":"Nucleation of calcium oxalate crystals by albumin: involvement in the prevention of stone formation.","volume":"55","author":"C Cerini","year":"1999","journal-title":"Kidney Int"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1128\/IAI.68.4.2366-2368.2000","article-title":"Staphylococcal exfoliative toxins cleave alpha- and beta-melanocyte-stimulating hormones.","volume":"68","author":"JV Rago","year":"2000","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2174\/156720507780362119","article-title":"Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver.","volume":"4","author":"DL Sparks","year":"2007","journal-title":"Curr Alzheimer Res"},{"key":"ref40","first-page":"41","article-title":"Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion.","volume":"107","author":"T Shirahama","year":"1982","journal-title":"Am J Pathol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000092315","article-title":"APP processing and the APP-KPI domain involvement in the amyloid cascade.","volume":"2","author":"M Menendez-Gonzalez","year":"2005","journal-title":"Neurodegener Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-328X(97)00045-4","article-title":"Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes.","volume":"47","author":"HA Rohan de Silva","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1432-1327.1999.00886.x","article-title":"The amyloid beta-protein precursor of Alzheimer&apos;s disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.","volume":"266","author":"MD Caswell","year":"1999","journal-title":"Eur J Biochem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"30929","DOI":"10.1074\/jbc.271.48.30929","article-title":"The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells.","volume":"271","author":"L Ho","year":"1996","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0002899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T09:55:57Z","timestamp":1631613357000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0002899"}},"subtitle":[],"editor":[{"given":"Edathara","family":"Abraham","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2008,8,6]]},"references-count":44,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2008,8,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0002899","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,6]]}}}