{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:08:28Z","timestamp":1772690908395,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T00:00:00Z","timestamp":1250035200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0006618","type":"journal-article","created":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T22:31:26Z","timestamp":1250029886000},"page":"e6618","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":90,"title":["ER Stress-Inducible Factor CHOP Affects the Expression of Hepcidin by Modulating C\/EBPalpha Activity"],"prefix":"10.1371","volume":"4","author":[{"given":"Susana J.","family":"Oliveira","sequence":"first","affiliation":[]},{"given":"Jorge P.","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo","family":"Picarote","sequence":"additional","affiliation":[]},{"given":"Vera M.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Rangel","sequence":"additional","affiliation":[]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[]},{"given":"S\u00e9rgio F.","family":"de Almeida","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2009,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","article-title":"The mammalian unfolded protein response.","volume":"74","author":"M Schroder","year":"2005","journal-title":"Annu Rev Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.cellbio.21.122303.120200","article-title":"Intracellular signaling by the unfolded protein response.","volume":"22","author":"S Bernales","year":"2006","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tcb.2003.11.001","article-title":"A trip to the ER: Coping with stress.","volume":"14","author":"DT Rutkowski","year":"2004","journal-title":"Trends Cell Biol"},{"key":"ref4","first-page":"289","article-title":"The ER function BiP is a master regulator of ER function.","volume":"75","author":"Hendershot","year":"2004","journal-title":"Mt Sinai J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cell.2005.11.040","article-title":"Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response.","volume":"124","author":"K Zhang","year":"2006","journal-title":"Cell"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/jhep.2003.50367","article-title":"Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells.","volume":"38","author":"KR You","year":"2003","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1101\/gad.6.3.439","article-title":"CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C\/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.","volume":"6","author":"D Ron","year":"1992","journal-title":"Genes Dev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"41163","DOI":"10.1074\/jbc.M202653200","article-title":"C\/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C\/EBP pathway and iron metabolism.","volume":"277","author":"B Courselaud","year":"2002","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.gastro.2007.10.011","article-title":"Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription.","volume":"134","author":"S Nishina","year":"2008","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/hep.21895","article-title":"Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol.","volume":"46","author":"DD Harrison-Findik","year":"2007","journal-title":"Hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.","volume":"102","author":"T Ganz","year":"2003","journal-title":"Blood"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.","volume":"306","author":"E Nemeth","year":"2004","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0140-6736(03)12602-5","article-title":"Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.","volume":"361","author":"KR Bridle","year":"2003","journal-title":"Lancet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis.","volume":"13","author":"JN Feder","year":"1996","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.4049\/jimmunol.178.6.3612","article-title":"Stimulation of an unfolded protein response impairs MHC class I expression.","volume":"178","author":"SF de Almeida","year":"2007","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.3748\/wjg.v13.i35.4725","article-title":"Liver iron transport.","volume":"13","author":"RM Graham","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1002\/j.1460-2075.1992.tb05223.x","article-title":"Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum.","volume":"11","author":"I Braakman","year":"1992","journal-title":"EMBO J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/bj3320213","article-title":"Characterization of the stress-inducing effects of homocysteine.","volume":"332","author":"PA Outinen","year":"1998","journal-title":"Biochem J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"35867","DOI":"10.1074\/jbc.M100747200","article-title":"Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.","volume":"276","author":"C Zhang","year":"2001","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1080\/10408360701428257","article-title":"The regulation of cellular iron metabolism.","volume":"44","author":"AC Chua","year":"2007","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1182\/blood-2007-08-106195","article-title":"Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C\/EBPalpha.","volume":"111","author":"JP Pinto","year":"2008","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1128\/MCB.9.3.1155","article-title":"Avian retroviral long terminal repeats bind CCAAT\/enhancer-binding protein.","volume":"9","author":"TA Ryden","year":"1989","journal-title":"Mol Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.cmet.2008.12.004","article-title":"Endoplasmic reticulum stress plays a central role in development of leptin resistance.","volume":"9","author":"L Ozcan","year":"2009","journal-title":"Cell Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1023\/A:1016175429877","article-title":"Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells.","volume":"7","author":"S Oyadomari","year":"2002","journal-title":"Apoptosis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response.","volume":"454","author":"K Zhang","year":"2008","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2172-10-10","article-title":"ER stress affects processing of MHC class I-associated peptides.","volume":"10","author":"DP Granados","year":"2009","journal-title":"BMC Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"12446","DOI":"10.1073\/pnas.220425597","article-title":"Role of C\/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT\/enhancer-binding protein-beta during adipogenesis.","volume":"97","author":"QQ Tang","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1002\/j.1460-2075.1995.tb00147.x","article-title":"Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153).","volume":"14","author":"N Batchvarova","year":"1995","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.devcel.2008.10.015","article-title":"UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.","volume":"15","author":"DT Rutkowski","year":"2008","journal-title":"Dev Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e374","DOI":"10.1371\/journal.pbio.0040374","article-title":"Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.","volume":"4","author":"DT Rutkowski","year":"2006","journal-title":"PLoS Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1182\/blood-2002-10-3235","article-title":"Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.","volume":"101","author":"E Nemeth","year":"2003","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bcmd.2008.01.006","article-title":"Iron responses in hepatic, intestinal and macrophage\/monocyte cell lines under different culture conditions.","volume":"41","author":"S Jacolot","year":"2008","journal-title":"Blood Cells Mol Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1056\/NEJMra031573","article-title":"Hereditary hemochromatosis \u2013 a new look at an old disease.","volume":"350","author":"A Pietrangelo","year":"2004","journal-title":"N Engl J Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00408-2","article-title":"The role of the iron responsive element in the control of ferroportin1\/IREG1\/MTP1 gene expression.","volume":"39","author":"A Lymboussaki","year":"2003","journal-title":"J Hepatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.bcmd.2006.09.008","article-title":"Hepatic iron metabolism gene expression profiles in HFE associated hereditary hemochromatosis.","volume":"38","author":"F Gleeson","year":"2007","journal-title":"Blood Cells Mol Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1006\/bcmd.2002.0587","article-title":"Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1.","volume":"29","author":"H Zoller","year":"2002","journal-title":"Blood Cells Mol Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"8175","DOI":"10.1073\/pnas.93.16.8175","article-title":"Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.","volume":"93","author":"MW Hentze","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/sj.onc.1202237","article-title":"Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.","volume":"17","author":"R Venugopal","year":"1998","journal-title":"Oncogene"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1074\/jbc.M210664200","article-title":"Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.","volume":"278","author":"EC Pietsch","year":"2003","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with \u201cmini-extracts,\u201d prepared from a small number of cells.","volume":"17","author":"E Schreiber","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0168-1656(00)00207-8","article-title":"A fluorescence based non-radioactive electrophoretic mobility shift assay.","volume":"78","author":"K Ruscher","year":"2000","journal-title":"J Biotechnol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1006\/meth.1999.0879","article-title":"In vivo cross-linking and immunoprecipitation for studying dynamic Protein: DNA associations in a chromatin environment.","volume":"19","author":"MH Kuo","year":"1999","journal-title":"Methods"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0006618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T23:39:32Z","timestamp":1558481972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0006618"}},"subtitle":[],"editor":[{"given":"Michael","family":"Polymenis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2009,8,12]]},"references-count":42,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2009,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0006618","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,12]]}}}